T12275
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PI3K
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NVP-QAV-572 is a inhibitor of PI3K(IC50 of 10 nM). |
T1989
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Apoptosis
HSP
Autophagy
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Luminespib (VER-52296) 是一种 HSP90抑制剂,抑制 HSP90α 和 HSP90β 的 IC50分别为 7.8 和 21 nM。 |
T21691
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NVP-DPP728 是一种有效、可逆、腈依赖性二肽基肽酶 IV (DPP-IV)抑制剂,Ki 值为 11 nM。NVP-DPP728 可抑制胰高血糖素样肽-1 (GLP-1)的降解,从而增强响应于葡萄糖摄入的胰岛素释放。NVP-DPP728 可用于糖尿病研究。 |
T3965
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GPR
Prostaglandin Receptor
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Fevipiprant (NVP-QAW039) 是一种选择性、强效、可逆的竞争性 CRTh2 拮抗剂,KD 值为1.1 nM,IC50为0.44 nM,能够引发人体嗜酸性粒细胞的形状变化。 |
T28221
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NVP-QAV-680 is a potent and selective antagonist of CRTh2 receptor. NVP-QAV-680 has nM functional potency for inhibition of CRTh2 driven human eosinophil and Th2 lymphocyte activation in vitro. |
T12273
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Others
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NVP-CGM097 sulfate is a potent and selective inhibitor of MDM2 (hMDM2, IC50 of 1.7±0.1 nM). |
T1502
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Apoptosis
Ferroptosis
Proteasome
DPP-4
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Vildagliptin (LAF237) 是一种选择性二肽基肽酶IV (DPP-IV) 抑制剂,在人 Caco-2 细胞中抑制 DPP-IV 的IC50为 3.5 nM。它具有出色的口服生物利用度和降血糖活性。 |
T4053
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VEGFR
FLT
c-RET
Bcr-Abl
c-Kit
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AST 487 (NVP-AST 487) 是 RET 激酶抑制剂 (IC50:880 nM),能够抑制 RET 自磷酸化,及下游效应器激活,也抑制 Flt-3 (IC50:520 nM)。 |
T70760
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NVP018, also known as BC 556, is a potent inhibitor of hepatitis B virus, hepatitis C virus (HCV), and HIV-1 replication, shows minimal inhibition of major drug transporters, and has a high barrier to generation of both HCV and HIV-1 resistance.. |
T1963
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Apoptosis
c-Met/HGFR
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Capmatinib (INCB28060) 是一种具有口服活性的,选择性的,ATP 竞争性的c-Met 激酶抑制剂,IC50值为0.13 nM。它有效抑制 c-Met 依赖性肿瘤细胞的增殖和迁移,可诱导细胞凋亡,有抗肿瘤活性。 |