T62816
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NVP-CLR457 (compound 40) 是一种口服具有活力的、平衡的泛 I 类 PI3K 抑制剂,具有抗肿瘤作用。NVP-CLR457 表现出显著的剂量依赖性 PK / PD / 疗效关系。 |
T72971
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(S)-JDQ-443 是 JDQ-443的异构体。JDQ-443 是一种口服有效和选择性的共价 KRAS G12C 抑制剂。JDQ-443 具有抗肿瘤活性。 |
T28851
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SRA880 is a non-peptide antagonist of somatostatin sst1-receptor. SRA880 displayed significantly lower affinity for the other human recombinant somatostatin receptors ( pK(d) < or = 6.0). SRA880 shows a certain binding affinity to the human dopamine D4 re |
T71982
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Ofloxacin HCl is a synthetic fluoroquinolone ( FLUOROQUINOLONES) antibacterial agent that inhibits the supercoiling activity of bacterial DNA GYRASE, halting DNA REPLICATION. |
T69262
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ABE171, also known as NVP-ABE171, is a potent and novel phosphodiesterase 4 inhibitor with anti-inflammatory activities. NVP-ABE171 inhibited the activity of phosphodiesterase 4A, 4B, 4C, and 4D with respective IC(50) values of 602, 34, 1230, and 1.5 nM. In human cells, NVP-ABE171 inhibited the eosinophil and neutrophil oxidative burst, the release of cytokines by T cells, and the tumor necrosis factor-alpha release from monocytes, in the nanomolar range. NVP-ABE171 inhibited the airway neutrophil influx and activation with an ED(50) in the range of 3 mg/kg. NVP-ABE171 shows activity both in vitro on human inflammatory cells and in vivo in animal models of lung inflammation. |
T16365
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Others
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Buparlisib Hydrochloride is an inhibitor of pan-class I PI3K (IC50: 52 nM/166 nM/116 nM/262 nM for p110α/p110β/p110δ/p110γ, respectively). |
T70181
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FFA3-Antagonist-6 is a PAM-antagonist of the function of C3 at FFA3. |
T30215
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AUY-954 is an effective selective S1P(1) modulator. It can significantly reduce the local expression of EAN rat sciatic nerve T cells, B cells, macrophage infiltration, inflammatory demyelination, interleukin-17 and matrix metalloproteinase-9. |
T26685
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AUY-954 is a potent and selective S1P(1) modulator. AUY-954 prevents experimental autoimmune neuritis in rats. |
T69681
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LC-1310 is an irreversible p97 inhibitor. |