目录号 | 产品详情 | 靶点 | |
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T36067 | ERK P2X Receptor p38 MAPK PAD | ||
Bongkrekic acid (Bongkrekic Acid (ammonium salt)) 是一种由伯克霍尔德菌(Burkholderia gladioli)分泌的线粒体毒素,抑制腺嘌呤核苷酸转位酶 (ANT)。Bongkrekic acid Bongkrekic acid 通过 p38、ERK、PAD4 和 P2X1 介导的信号传导诱导中性粒细胞胞外陷阱。 | |||
T39183 | |||
Okadaic acid ammonium salt, a marine toxin, serves as an inhibitor of protein phosphatases (PP), displaying a higher affinity for PP2A (IC 50 =0.1-0.3 nM) alongside inhibitory effects on PP1 (IC 50 =15-50 nM), PP3 (IC 50 =3.7-4 nM), PP4 (IC 50 =0.1 nM), and PP5 (IC 50 =3.5 nM), but does not affect PP2C. By inhibiting PPs, this compound promotes protein phosphorylation and acts as a tumor promoter. Additionally, it is involved in inducing tau phosphorylation. | |||
T82415 | |||
Fasciculin-I 是从曼巴蛇的毒液中分离出的化合物。该物质通过抑制乙酰胆碱酯酶(AChE)来发挥其毒性,同时阻碍烟碱乙酰胆碱受体与α-神经毒素以及心脏毒素与细胞膜的相互作用。 | |||
T74647 | |||
BT5528 是一种双环肽毒素结合物,一种EphA2激活剂。BT5528 由双环肽和AuristatinE 组成,是 BCY6099 的衍生物。BT5528 在大鼠模型中显示出强大的抗肿瘤活性,不导致出血或引起凝血毒性。 | |||
T36859 | |||
C16 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from C16 lactosylceramide . C16 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease. C16 globotriaosylceramide is also upregulated in plasma of patients with ovarian carcinoma compared to those with benign ovarian tumors or uterine fibroids. | |||
T80179 | Sodium Channel | ||
GrTx1是一种从Grammostola rosea蜘蛛的毒液中分离的肽毒素。该分子能够阻断sodium channel,对Nav1.1,Nav1.2,Nav1.3,Nav1.4,Nav1.6和Nav1.7具有不同的抑制作用,IC50值分别为0.63 µM, 0.23 µM, 0.77 µM, 1.29 µM, 0.63 µM和0.37 µM,适用于神经疾病的研究领域。 | |||
T82764 | |||
Cd1a是从非洲蜘蛛Ceratogyrus darlingi中提取的β-毒素,具有调节钙离子通道的功能。它能够抑制人类的钙离子通道(Cav2.2)(IC50 2.6 μM)以及小鼠的钠离子通道(Nav1.7),有望用于开发治疗外周疼痛的药物。 | |||
T78290 | |||
Obiltoxaximab是一款针对炭疽保护抗原(PA)的高效单克隆抗体。它在阻断炭疽毒素组装及其对靶细胞的毒害中发挥关键作用。此外,Obiltoxaximab也适用于进行吸入性炭疽感染动物模型到人类剂量转换的研究。 | |||
T82936 | Sodium Channel | ||
ATX-II TFA为源自海葵(Anemonia sulcata)毒素的特定Na+通道调节剂,能使细胞培养物对Na+、Halothane、Caffeine和Ryanodine敏感,并可诱发肺静脉心律失常和心房颤动。 | |||
T83811 | |||
2'(3')-O-Anthraniloyladenosine-5'-O-triphosphate(2'-ANT-ATP)与3'-ANT-ATP是荧光ATP衍生物,可自发地进行异构化。在水中,2'(3')-ANT-ATP的激发波长为330 nm时,发射最大波长为428 nm。它对哺乳动物腺苷酸环化酶(AC1)、AC2及AC5显示出抑制作用,抑制常数(Kis)分别为130、640和120 nM。此外,它还能抑制百日咳杆菌腺苷酸环化酶毒素CyaA(在锰和镁存在下,Kis分别为1.3和20 µM)、炭疽杆菌腺苷酸环化酶毒素水肿因子(在锰和镁存在下,Kis分别为0.44和5.15 µM)以及大肠杆菌重组酶A(RecA;Ki = 6.3 µM)。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-02953 | TEM8/ANTXR1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
ANTXR1 contains 1 VWFA domain and belongs to the ATR family. ATR (Ataxia telangiectasia and Rad3 related) and ATM (Ataxia telangiectasia mutated) are closely related kinases that are activated by DNA damage. They are serine-threonine protein kinases and belongs to the phosphatidylinositol 3' kinase-like kinase (PIKK) family. Upon recruitment by the DNA damage binding proteins/complexes (ATRIP for ATR; MRN for ATM), ATM/ATR initiate the DNA damage checkpoint by phosphorylating a number of key proteins. ANTXR1 interacts with extracellular matrix proteins and with the actin cytoskeleton. It functions in cell attachment and migration. ANTXR1 also mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. It plays a role in the angiogenic response of cultured umbilical vein endothelial cells.
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TMPH-00361 | Beta-mammal toxin Cn2 Protein, Centruroides noxius, Recombinant (His) | Centruroides noxius | P. pastoris (Yeast) | ||
Mammal beta-toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the activation voltage to more negative potentials. This toxin is active against mammals. Beta-mammal toxin Cn2 Protein, Centruroides noxius, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 9.6 kDa and the accession number is P01495.
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TMPH-03626 | Beta-mammal/insect toxin Ts1 Protein, Tityus serrulatus, Recombinant (His & Myc) | Tityus serrulatus | Baculovirus Insect Cells | ||
Beta-mammal/insect toxin Ts1 Protein, Tityus serrulatus, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 10.8 kDa and the accession number is P15226.
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TMPH-00432 | Diphtheria toxin Protein, Corynephage omega, Recombinant (His & Myc) | Corynephage omega | E. coli | ||
Diphtheria toxin Protein, Corynephage omega, Recombinant (His & Myc) is expressed in E. coli.
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TMPH-03627 | Beta-mammal/insect toxin Ts1 Protein, Tityus serrulatus, Recombinant (E. coli, His & Myc) | Tityus serrulatus | E. coli | ||
Beta-mammal/insect toxin Ts1 Protein, Tityus serrulatus, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 14.3 kDa and the accession number is P15226.
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TMPH-03628 | Beta-toxin Tz1 Protein, Tityus zulianus, Recombinant (His & Myc) | Tityus zulianus | E. coli | ||
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. Strongly affects skeletal muscle channels Nav1.4/SCN4A, poorly affects the neuronal channels Nav1.6/SCN8A and Nav1.2/SCN2A. Induces spastic paralysis of rear limbs, increased salivation, apnea, tachycardia and increased perspiration. Beta-toxin Tz1 Protein, Tityus zulianus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 14.8 kDa and the accession number is Q2NME3.
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TMPH-00362 | Beta-mammal toxin Css4 Protein, Centruroides suffusus, Recombinant (His & SUMO) | Centruroides suffusus | E. coli | ||
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin is active only on mammals. Beta-mammal toxin Css4 Protein, Centruroides suffusus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 23.6 kDa and the accession number is P60266.
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TMPH-03625 | Alpha-mammal toxin Ts2 Protein, Tityus serrulatus, Recombinant (His & Myc) | Tityus serrulatus | Baculovirus Insect Cells | ||
Alpha-mammal toxin Ts2 Protein, Tityus serrulatus, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 10.9 kDa and the accession number is P68410.
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TMPH-00054 | AaH II Protein, Androctonus australis, Recombinant (His & SUMO) | Androctonus australis | E. coli | ||
AaH II Protein, Androctonus australis, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 23.3 kDa and the accession number is P01484.
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TMPH-03522 | Alpha-hemolysin Protein, S. aureus, Recombinant (His) | Staphylococcus aureus | P. pastoris (Yeast) | ||
Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Inhibits host neutrophil chemotaxis to the lesion region (Probable). Heptamer oligomerization and pore formation is required for lytic activity.
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TMPH-03523 | Alpha-hemolysin Protein, S. aureus, Recombinant (His & SUMO) | Staphylococcus aureus | E. coli | ||
Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Inhibits host neutrophil chemotaxis to the lesion region (Probable). Heptamer oligomerization and pore formation is required for lytic activity.
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TMPH-03075 | 3FTx-Oxy6 Protein, Oxyuranus microlepidotus, Recombinant (His & Myc & SUMO) | Oxyuranus microlepidotus | E. coli | ||
3FTx-Oxy6 Protein, Oxyuranus microlepidotus, Recombinant (His & Myc & SUMO) is expressed in E. coli.
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TMPH-00606 | CDTC Protein, E. coli, Recombinant (His & Myc) | E. coli | E. coli | ||
Part of the tripartite complex that is required for the CDT activity. CdtC, along with CdtA, probably forms a heterodimeric subunit required for the delivery of CdtB. CDTC Protein, E. coli, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 25.7 kDa and the accession number is Q46670.
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TMPJ-00744 | Toxin B Protein, Vibriocholerae, Recombinant | Vibrio cholerae | E. coli | ||
Cholera toxin is protein complex secreted by the bacterium Vibrio cholerae. It is responsible for the massive, watery diarrhea characteristic of cholera infection. Cholera enterotoxin subunit B (CTXB) pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself.
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TMPH-03026 | CARDS Protein, Mycoplasma pneumoniae, Recombinant (His & Myc) | Mycoplasma pneumoniae | E. coli | ||
Acts as an ADP-ribosylating toxin, which may transfer the ADP-ribosyl group from NAD(+) to specific amino acids in target proteins. Elicits cytopathic effects in mammalian cells, such as disorganization and disruption of respiratory epithelial integrity in tracheal epithelium and vacuolization in the cytoplasm of CHO and HeLa cells.
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TMPY-00380 | ANTXR2 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
ANTXR2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 57.4 kDa and the accession number is P58335-4.
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TMPY-04094 | ANTXR2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
ANTXR2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.3 kDa and the accession number is Q3TCL6.
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TMPH-00837 | BjaIT Protein, Hottentotta judaicus, Recombinant (His & Myc) | Hottentotta judaicus | E. coli | ||
Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin is active against insects (para/tipE). BjaIT Protein, Hottentotta judaicus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 14.4 kDa and the accession number is Q56TT9.
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TMPH-03534 | Delta-hemolysin Protein, S. aureus, Recombinant (His & KSI) | Staphylococcus aureus | E. coli | ||
Lyses erythrocytes and many other mammalian cells. Delta-hemolysin Protein, S. aureus, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 18.3 kDa and the accession number is P0A0M1.
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TMPH-00056 | Delta-AITX-Avd1c Protein, Anemonia sulcata, Recombinant (His) | Anemonia sulcata | P. pastoris (Yeast) | ||
Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation. Has a strong effect on crustaceans and insects (DmNav1) and a weaker effect on mammals. This toxin is highly potent at mammalian Nav1.1/SCN1A (EC(50)=6.01 nM) and Nav1.2/SCN2A (EC(50)=7.88 nM). It has also great activity on Nav1.5/SCN5A (EC(50)=49.05 nM), Nav1.4/SCN4A (EC(50)=109.49 nM) and Nav1.6/SCN8A (EC(50)=about 180 nM) and is less potent on Nav1.3/SCN3A (EC(50)=759.22 nM) (when measured as the increase in the slow component).
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TMPJ-01333 | TEM8/ANTXR1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Anthrax Toxin Receptor 1 (ANTXR1) is a single-pass type I membrane protein that belongs to the ATR family. ANTXR1 contains one VWFA domain and binds PA through the VWA domain. ANTXR1 is highly expressed in tumor endothelial cells. ANTXR1 plays a role in cell attachment and migration. ANTXR1 interacts with extracellular matrix proteins and the actin cytoskeleton, it mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. It is also involved in the angiogenic response of cultured umbilical vein endothelial cells, up-regulated in cultured angiogenic umbilical vein endothelial cells. Defects in ANTXR1 are associated with susceptibility to hemangioma capillary infantile (HCI).
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TMPH-00604 | CDTA Protein, E. coli, Recombinant (His) | E. coli | E. coli | ||
CDTs are cytotoxins which induce host cell distension, growth arrest in G2/M phase, nucleus swelling, and chromatin fragmentation in HeLa cells. CdtA, along with CdtC, probably forms a heterodimeric subunit required for the delivery of CdtB.
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TMPH-00403 | Toxin A Protein, Clostridioides difficile, Recombinant (His) | Clostridioides difficile | E. coli | ||
Toxin A Protein, Clostridioides difficile, Recombinant (His) is expressed in E. coli.
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TMPY-00615 | ANTXR2 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
ANTXR2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 57.9 kDa and the accession number is Q3TCL6.
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TMPH-00605 | CDTB Protein, E. coli, Recombinant (His & Myc & SUMO) | E. coli | E. coli | ||
Part of the tripartite complex that is required for the CDT activity. CdtB exhibits a DNA-nicking endonuclease activity, and very probably causes DNA damage in intoxicated cells. This damage induces G2/M cell cycle arrest, chromatin fragmentation, cell distention and nucleus enlargement. CDTB Protein, E. coli, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 47.4 kDa and the accession number is Q46669.
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TMPH-03551 | Exfoliative toxin A Protein, S. aureus, Recombinant (His) | Staphylococcus aureus | E. coli | ||
Has serine protease-like properties and binds to the skin protein profilaggrin. Cleaves substrates after acidic residues. Exfoliative toxins cause impetigous diseases commonly referred as staphylococcal scalded skin syndrome (SSSS).
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TMPH-00510 | DT3C Protein, Recombinant (His) | Corynephage beta | E. coli | ||
DT3C Protein, Recombinant (His) is expressed in E. coli.
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TMPH-03586 | Toxin zeta Protein, S. agalactiae, Recombinant (His) | Streptococcus agalactiae | P. pastoris (Yeast) | ||
Toxic component of a type II toxin-antitoxin (TA) system. Phosphorylates UDP-N-acetyl-D-glucosamine (UNAG) on the 3'-hydroxyl group of the N-acetyl-D-glucosamine moiety, yielding UNAG-3P. UNAG-3P inhibits MurA, the first committed step in cell wall synthesis, which is then blocked. Phosphorylation is inhibited by cognate epsilon antitoxin. Part of a postsegregational killing (PSK) system involved in the killing of plasmid-free cells. The zeta toxin induces programmed cell death. Toxin zeta Protein, S. agalactiae, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 34.7 kDa and the accession number is P0A4M2.
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TMPH-00423 | Tetanus toxin Protein, Clostridium tetani, Recombinant (B2M & His) | Clostridium tetani | E. coli | ||
Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2. Tetanus toxin Protein, Clostridium tetani, Recombinant (B2M & His) is expressed in E. coli expression system with N-6xHis-B2M tag. The predicted molecular weight is 66.3 kDa and the accession number is P04958.
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TMPH-03552 | Exfoliative toxin B Protein, S. aureus, Recombinant (His & Myc) | Staphylococcus aureus | E. coli | ||
Has serine protease-like properties and binds to the skin protein profilaggrin. Cleaves substrates after acidic residues. Exfoliative toxins cause impetigous diseases commonly referred as staphylococcal scalded skin syndrome (SSSS). Exfoliative toxin B Protein, S. aureus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 34.8 kDa and the accession number is P09332.
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TMPH-00387 | Toxin CfTX-1 Protein, Chironex fleckeri, Recombinant (His & SUMO) | Chironex fleckeri | E. coli | ||
Toxin CfTX-1 Protein, Chironex fleckeri, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 65.1 kDa and the accession number is A7L035.
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TMPH-00055 | Alpha-toxin Amm8 Protein, Androctonus mauritanicus, Recombinant (His & Myc) | Androctonus mauritanicus | Baculovirus Insect Cells | ||
Alpha-toxin Amm8 Protein, Androctonus mauritanicus, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 11.3 kDa and the accession number is Q7YXD3.
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TMPY-02447 | Shiga toxin II subunit B Protein, E. coli, Recombinant (His) | E. coli | E. coli | ||
E. Coli STX2B is a subunit of Stx2. Stx2, together with Stx1, formed a family of related toxins which are known as shiga toxins. Shiga toxins are mainly produced by the bacteria S. dysenteriae and the Shigatoxigenic group of Escherichia coli, which includes serotypes O157:H7, O104:H4, and other enterohemorrhagic E. coli (EHEC). A total of 3222 outbreak cases (including 39 deaths) have been reported in northern Germany in May through June 2011. The outbreak strain was typed as an enteroaggregative Shiga-toxin–producing E. coli O104:H4, producing extended-spectrum beta-lactamase. The toxin has two subunits—A and B. E. Coli STX2B is the B subunit. It is a pentamer that binds to specific glycolipids on the host cell, specifically globotriaosylceramide. Following this, the A subunit is internalised and cleaved into two parts. Stx2 has been found to be approximately 400 times more toxic (as quantified by LD50 in mice) than Stx-1. The Stx1 and Stx2 B subunits form a pentameric structure that binds to globotriaosylceramide receptors on eukaryotic cells and promotes endocytosis.
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TMPY-02439 | Rac2 Protein, Human, Recombinant (His) | Human | E. coli | ||
Ras-related C3 botulinum toxin substrate 2 (Rac2) is a small G-protein belonging to the Ras subfamily of the GTPase family. Rac2 acts as an "on / off" switch for signal transduction cascades and motilities. When GDP is attached to the small G-protein, the enzyme is inactivated. Release of the GDP and replace of the GTP cativate the GTPasee. Rac2 remains active until the GTP is hydrolyzed to GDP. Rac2 is a hematopoietic-specific Rho family GTPase implicated as an important constituent of the NADPH oxidase complex and shares 92% amino acid identity with the ubiquitously expressed Rac1. The small G-protein Rac2 regulates the rearrangements of actin and membrane necessary for Fcy receptor-mediated phagocytosis by macrophages. Activated Rac2 binds to the p21-binding domain of PAK1 and this binding provided a basis for microscopic methods to localize activation of these G proteins inside cells.
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TMPY-01187 | Rac1 Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells | ||
RAC1 is a GTPase that belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for RAC1 gene. RAC1 is a plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. RAC1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophage. RAC1 is essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. RAC1's isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP-dependent manner, suggesting that the insertion does not completely abolish effector interaction. Stat3 is an important transcription factor that regulates both proinflammatory and anti-apoptotic pathways in the heart. It forms a multiprotein complex with RAC1 and PKC in an H/R-dependent manner by expression of constitutively active Rac1 mutant protein, and by RNA silencing of RAC1. Selective inhibition of PKC with calphostin C produces a marked suppression of Stat3 S727 phosphorylation. The association of Stat3 with Rax1 occurs predominantly at the cell membrane, but also inside the nucleus, and occurs through the binding of the coiled-coil domain of Stat3 to the 54 NH(2)-terminal residues of RAC1. Transfection with a peptide comprising the NH(2)-terminal 17 amino acid residues of RAC1-dependent signaling pathways resulting in a physical association between Rac1 and Stat3 and the formation of a novel multiprotein complex with PKC.
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TMPH-03652 | Ustilago maydis P6 virus (UmV6) KP6 killer toxin (His) | UmV6 | P. pastoris (Yeast) | ||
This protein is lethal to sensitive cells of the same or related species. The KP6 alpha subunit is known to recognize some cellular receptors before interaction of the complex with KP6 beta, precipitating cell death. Ustilago maydis P6 virus (UmV6) KP6 killer toxin (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 10.6 kDa and the accession number is P16948.
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TMPJ-01286 | proHB-EGF Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Heparin-binding EGF-like growth factor (HB-EGF) is a 1216 kDa member of the epidermal growth factor (EGF) family. It possesses an EGFlike domain, and a heparin-binding motif. Mature HBEGF is a soluble peptide that arises from proteolytic processing of the transmembrane form. Human HBEGF shows 76% and 73% aa sequence identity with rat and mouse HBEGF, respectively. It is required for normal cardiac valve formation and normal heart function, promotes smooth muscle cell proliferation. It may be involved in macrophage-mediated cellular proliferation; it is mitogenic for fibroblasts, but not endothelial cells. HBEGF classified as a group 2 ErbB ligand based on its ability to activate both the EGF/ErbB1 and ErbB4 receptors. Activity associated with ErbB4 binding appears to be limited to nonmitogenic actions, while EGFR binding induces both mitogenic and nonmitogenic activity.
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TMPH-00635 | Heat-stable enterotoxin ST-IA/ST-P Protein, E. coli, Recombinant (GST) | E. coli | E. coli | ||
Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells.
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TMPH-00633 | Heat-stable enterotoxin A2 Protein, E. coli, Recombinant (His & Myc & SUMO) | E. coli | E. coli | ||
Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells.
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TMPH-00630 | Heat-labile enterotoxin A chain Protein, E. coli, Recombinant (His & Myc) | E. coli | E. coli | ||
The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.
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TMPH-00631 | Heat-labile enterotoxin B chain Protein, E. coli, Recombinant (His) | E. coli | E. coli | ||
The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase.
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TMPH-00632 | Heat-labile enterotoxin B chain Protein, E. coli, Recombinant (His & Myc) | E. coli | E. coli | ||
The biological activity of the toxin is produced by the A chain, which activates intracellular adenyl cyclase. Heat-labile enterotoxin B chain Protein, E. coli, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 19.2 kDa and the accession number is P32890.
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TMPH-00634 | Heat-stable enterotoxin ST-2 Protein, E. coli, Recombinant | E. coli | E. coli | ||
Toxin which activates the particulate form of guanylate cyclase and increases cyclic GMP levels within the host intestinal epithelial cells. Heat-stable enterotoxin ST-2 Protein, E. coli, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 2.0 kDa and the accession number is P01560.
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TMPH-03548 | Enterotoxin type G Protein, S. aureus (strain N315), Recombinant (His) | Staphylococcus aureus | P. pastoris (Yeast) | ||
Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death. Enterotoxin type G Protein, S. aureus (strain N315), Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 29.0 kDa and the accession number is P0A0L7.
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TMPH-03549 | Enterotoxin type H Protein, S. aureus, Recombinant (His) | Staphylococcus aureus | P. pastoris (Yeast) | ||
Enterotoxin type H Protein, S. aureus, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 27.1 kDa and the accession number is P0A0M0.
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TMPY-00248 | Lymphotoxin Beta Protein, Cynomolgus, Recombinant (His) | Cynomolgus | Baculovirus Insect Cells | ||
LTB (Lymphotoxin Beta) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. Heat-labile enterotoxin B subunit (LTB) of enterotoxigenic Escherichia coli (ETEC) is both a strong mucosal adjuvant and immunogen. It is a subunit vaccine candidate to be used against ETEC-induced diarrhea. It has already been expressed in several bacterial and plant systems.LTB provokes a systemic immune response and exerts adjuvant effects on mucosal immune responses to unrelated antigens. Diseases associated with LTB include Synovitis and Myasthenic Syndrome, Congenital, 2C, Associated With Acetylcholine Receptor Deficiency.
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TMPH-03543 | Enterotoxin type C-3 Protein, S. aureus, Recombinant (His & SUMO) | Staphylococcus aureus | E. coli | ||
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of proinflammatory cytokines. Causes also the intoxication staphylococcal food poisoning syndrome. Enterotoxin type C-3 Protein, S. aureus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 43.6 kDa and the accession number is P0A0L5.
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TMPH-03037 | Alpha-cobratoxin Protein, Naja kaouthia, Recombinant (GST & His & Myc) | Naja kaouthia | E. coli | ||
Monomer: binds with high affinity to muscular (alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND) nAChR (tested on Torpedo californica, Kd=0.2-4.5 nM) and neuronal alpha-7/CHRNA7 nicotinic acetylcholine receptors (Kd=13-105 nM). Also inhibits GABA(A) channels. Heteropentamer targets studied are composed of alpha-1-beta-3-gamma-2 (GABRA1-GABRB3-GABRG2) subunits (IC(50)=236 nM), alpha-1-beta-2-gamma-2 (GABRA1-GABRB2-GABRG2) subunits (IC(50)=469 nM), alpha-2-beta-2-gamma-2 (GABRA2-GABRB2-GABRG2) subunits (IC(50)=485 nM), alpha-5-beta-3-gamma-2 (GABRA5-GABRB3-GABRG2) subunits (IC(50)=635 nM), and alpha-2-beta-3-gamma-2 (GABRA2-GABRB3-GABRG2) subunits (IC(50)=1099 nM) (activated by 10 uM GABA).; Homodimer: binds with high affinity (but lower than the monomeric form) to muscular (IC(50)=9.7 nM) and with low affinity to neuronal alpha-7/CHRNA7 nAChRs (IC(50)=1370 nM). However, it acquires (compared to the monomeric form) the capacity to block alpha-3/beta-2 (CHRNA3/CHRNB2) nAChRs.; Heterodimer with cytotoxin 3 (AC P01446): is slightly more active than the homodimer in inhibiting alpha-7/CHRNA7 nAChR and is considerably more active in blocking the alpha-3-beta-2/CHRNA3-CHRNB2 nAChR.
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TMPH-03709 | Viscotoxin-A3 Protein, Viscum album, Recombinant (His) | Viscum album | P. pastoris (Yeast) | ||
Thionins are small plant proteins which are toxic to animal cells. They seem to exert their toxic effect at the level of the cell membrane. Their precise function is not known. Viscotoxin-A3 Protein, Viscum album, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 6.8 kDa and the accession number is P01538.
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TMPH-00818 | Delta-theraphotoxin-Hm1a Protein, Heteroscodra maculata, Recombinant (His & Myc & SUMO) | Heteroscodra maculata | E. coli | ||
Delta-theraphotoxin-Hm1a Protein, Heteroscodra maculata, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO and C-Myc tag. The predicted molecular weight is 21.5 kDa and the accession number is P60992.
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