Beta-mammal/insect toxin Ts1 Protein, Tityus serrulatus, Recombinant (His & Myc)

Beta-mammal/insect toxin Ts1 Protein, Tityus serrulatus, Recombinant (His & Myc) is expressed in Baculovirus.

规格	价格/CNY		数量
20 μg	￥ 3,120	20日内发货
100 μg	￥ 8,760	20日内发货
500 μg	￥ 12,500	20日内发货

规格

价格/CNY

货期

数量

20 μg

￥ 3,120

20日内发货

100 μg

￥ 8,760

20日内发货

500 μg

￥ 12,500

20日内发货

产品描述	Beta-mammal/insect toxin Ts1 Protein, Tityus serrulatus, Recombinant (His & Myc) is expressed in Baculovirus.

种属	Tityus serrulatus
表达系统	Baculovirus
标签	N-terminal 10xHis-tagged and C-terminal Myc-tagged
蛋白编号	P15226
别名	Toxin II-11, Beta-like toxin Ts1, Ts7, Beta-mammal/insect toxin Ts1, PT-Mice-Ins-beta NaTx6.1, Toxin VII, Tityustoxin VII, Ts VII, Toxin III-10
氨基酸序列	KEGYLMDHEGCKLSCFIRPSGYCGRECGIKKGSSGYCAWPACYCYGLPNWVKVWDRATNKC Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
蛋白构建	21-81 aa
蛋白纯度	> 85% as determined by SDS-PAGE.
分子量	10.8 kDa (predicted)

缓冲液	Tris-based buffer,50% glycerol
复溶方法	A hardcopy of COA with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
存储	Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
运输方式	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
研究背景	Voltage-gated sodium channels (Nav) gating-modifier. Acts both as alpha- and beta-toxin, since it affects not only activation but also inactivation of Nav channels (Probable). Binds to Nav domain DII and impairs the four Nav channel voltage sensors movements. Depending on Nav channel subtypes tested, can also bind Nav domains DIII (low affinity) and DIV (very low affinity). Acts on almost all the Nav channels tested (mammalian Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.4/SCN4A, Nav1.5/SCN5A, Nav1.6/SCN8A, Nav1.9/SCN11A, and insect DmNav1). Is highly active against both mammals and insects. Irreversibly modulates DmNav channels. Other Ts1 activities have been studied, such as immunomodulation, antimicrobial activity or exocrine secretion (Probable). This toxin exhibits an antifungal activity against filamentous fungi. In vitro, it has an important immunomodulatory effect on macrophages by stimulating the release of proinflammatory cytokines. It also shows an activity in exocrine secretion in pancreas, stomach and adrenal gland.

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Beta-mammal/insect toxin Ts1 Protein, Tityus serrulatus, Recombinant (His & Myc)

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