T69991
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Difenamizole HCl is the salt form of Difenamizole, a non-steroidal anti-inflammatory drug (NSAID) and analgesic of the pyrazolone group related to metamizole. It has monoaminergic properties, including inhibition of monoamine oxidase, augmentation of pargyline-induced elevation of striatal dopamine levels, inhibition of K+-induced striatal dopamine release, and inhibition of the reuptake of dopamine. |
T77610
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Others
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WAY-339495 可能具有抗肿瘤抗炎和镇痛活性,可用来研究肥胖、心血管疾病、糖尿病、神经退行性疾病、阿尔茨海默病和中风。 |
TP1882
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Orphanin FQ(1-11) is a peptide fragment containing amino acids 1-11 of Nociceptin. Orphanin FQ(1-11) is a potent agonist of the ORL1/KOR-3 receptor (Ki = 55 nM) and displays no affinity for opioid receptors, including μ, δ, κ1 and κ3 receptors (Ki >1000 nM). Orphanin FQ(1-11) displays analgesic properties in CD-1 mice. |
T28235
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OMDM169 is a potent and selective MAGL inhibitor. OMDM169 could enhances 2-AG levels and of exerts analgesic activity via indirect activation of cannabinoid receptors. OMDM169 exhibited 0.13 microM
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T36851
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Connexin43 mimetic peptide. Reduces swelling, astrogliosis, neuroinflammation and neuronal cell death following spinal cord injury ex vivo and in vivo. Exhibits analgesic effects in models of neuropathic pain.
O'Carroll et al (2008) Connexin 43 mimetic peptides reduce swelling, astrogliosis and neuronal cell death after spinal cord injury. Cell.Commun.Adhes. 15 27 PMID:18649176 |Mao et al (2017) Characterisation of Peptide5 systemic administration for treating traumatic spinal cord injured rats. Exp.Brain.Res. 235 3033 PMID:28725925 |Kim et al (2017) Characterising the mode of action of extracellular Connexin43 channel mimetic peptides in an in vitro ischemia injury model. Biochem.Biophys.Acta. 1861 68 PMID:27816754 |Tonkin et al (2017) Attenuation of mechanical pain hypersensitivity by treatment with Peptide5, a connexin-43 mimetic peptide, involves inhibition of NLRP3 inflammasome in nerve-injured mice. Exp.Neurol. 300 1 PMID:29055716 |
T80164
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α-Conotoxin PeIA 是一种具有镇痛作用的 α-芋螺毒素,能够抑制 α6β4、α9α10 和 α3β2 nAChR。同时,α-Conotoxin PeIA 亦作为 N 型 calcium channel 的效力抑制剂,通过激活 GABAB 受体发挥作用。 |
T75792
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Huwentoxin XVI TFA,一种来自鸟蛛 Ornithoctonus huwena 的止痛剂,一种高度可逆和选择性的哺乳动物 N 型钙通道 (N-type calcium channel) (IC50约为 60 nM) 拮抗剂。Huwentoxin XVI TFA 对电压门控的 T 型钙通道,钾通道或钠通道没有影响。 |
T78559
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PDE7-IN-3(例2)是一种具有潜在镇痛活性的PDE7磷酸二酯酶抑制剂,可用于探究炎性、神经性、内脏性及伤害性疼痛。 |
T73655
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Frakefamide TFA 是一种有效的止痛药物,作为μ 受体的选择性外围激动剂。该化合物不能穿透血脑屏障,因此不进入中枢神经系统。 |
T80176
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Sodium Channel
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Crotamine是一种含42个氨基酸、有三个二硫键交联的毒素,具有镇痛和肌坏死活性,作为Na+通道调节剂。它能与脂质膜相互作用,并可从Crotalus durissus terrificus的毒液中分离得到。 |