T78559
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PDE7-IN-3(例2)是一种具有潜在镇痛活性的PDE7磷酸二酯酶抑制剂,可用于探究炎性、神经性、内脏性及伤害性疼痛。 |
T73655
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Frakefamide TFA 是一种有效的止痛药物,作为μ 受体的选择性外围激动剂。该化合物不能穿透血脑屏障,因此不进入中枢神经系统。 |
T72146
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Loxoprofenol-SRS tromethamine (HR1405-01) 为Loxoprofen的活性代谢物,为一种可静脉注射的安全非甾体抗炎药(NSAID),展现出良好的抗炎及镇痛效果。 |
T76335
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Dynorphin (2-17), amide (porcine) 为 dynorphin 衍生物,展现镇痛效果。该化合物源自前体蛋白强啡肽原,涉及阿片肽类,参与疼痛调控、成瘾及情绪调节等生理过程。 |
TN1951
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HIF
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Moracin O shows significant neuroprotective, and analgesic activities, it also has a strong protective influence against doxorubicin-induced cardiomyopathy in H9c2 cells with the EC50 value of 4.5 ± 1.3 μM. Moracin O exhibits potent in vitro inhibitory ac |
T68847
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Aspirin calcium is the prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5) |
T61850
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Adenosine receptor inhibitor 1 is a highly potent and selective antagonist of adenosine receptor (AR). It exhibits exceptional affinity for A1 AR, A2A AR, A2B AR, and A3 AR, with respective Ki values of >1000, 68.5, >1000, >1000 nM. This compound demonstrates notable antinociceptive, anti-inflammatory, and peripheral analgesic properties. Therefore, Adenosine receptor inhibitor 1 holds great promise for investigating cancer and neurodegenerative diseases [1]. |
T61674
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COX-2/5-LOX-IN-1 (compound 3a), a benzothiophen-2-yl pyrazole carboxylic acid derivative, is a potent and dual inhibitor of COX-2 / 5-LOX. It exhibits superior analgesic and anti-inflammatory properties compared to Celecoxib and Indomethacin. COX-2/5-LOX-IN-1 displays strong inhibitory activity against COX-1, COX-2, and 5-LOX, with IC50 values of 12.13 μM, 0.4 μM, and 4.96 μM, respectively [1]. |
TMIH-0325
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MefenaMic Acid-d4 是 MefenaMic Acid 的氘代化合物。MefenaMic Acid 的 CAS 号为 61-68-7。Mefenamic acid 是一种非甾体抗炎剂,可竞争性抑制hCOX-1和hCOX-2,IC50值分别为 40 nM 和 3 μM。 |
T66097
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Antifungal
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Ethyl 4-bromocrotonate ((E)-Ethyl 4-bromobut-2-enoate) 是一种抗菌化合物,属于酯类。作为一种重要的医药中间体,它已被用作酶催化反应的底物,用作研究酶动力学的工具。此外,它也被发现具有抗炎和镇痛作用。 |