目录号 | 产品详情 | 靶点 | |
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T12165 | AChR | ||
nAChR agonist 1 (DUN71755) 是一种脑渗透性和口服有效的正变构 α7 烟碱乙酰胆碱受体 (α7 nAChR) 调节剂。它在 Ca2+中,对内源性表达 α7 nAChR 的人 IMR-32 神经母细胞瘤细胞的EC50为 0.32 μM。它可用于阿尔茨海默病的研究。 | |||
T39771 | |||
nAChR agonist CMPI hydrochloride is a potent and selective positive allosteric modulator (PAM) of nAChR containing a α4:α4 subunit interface. nAChR agonist CMPI hydrochloride enhances the response of (α4) 3 (β2) 2 nAChR to ACh (10 μM) with an EC 50 of 0.26 μM. nAChR agonist CMPI hydrochloride has potential for the research of nicotine dependence and many neuropsychiatric conditions associated with decreased brain cholinergic activity. | |||
T40177 | |||
nAChR agonist 2 (compound 8) is a selective alpha4beta2 (α4β2) nAChR agonist ( K d =26 nM). | |||
T8868 | AChR | ||
4BP-TQS 是 α7nAChR 变构激动剂。它利用变构跨膜位点激活 nAChRs。 | |||
T9542 | AChR | ||
NS3861 是烟碱型乙酰胆碱受体的激动剂,对α3β4 nAChR 具有高亲和力。能够分别与α3β4 (Ki:0.62 nM)、α3β2 (Ki:25 nM)、α4β4 (Ki:7.8 nM)、α4β2 (Ki:55 nM) 结合。 | |||
T14094 | AChR | ||
Acetamiprid 是广泛使用的新烟碱类杀虫剂,是一种烟碱型乙酰胆碱受体激动剂,与神经肌肉和生殖系统疾病有关。 | |||
T17300 | AChR | ||
(-)-(S)-B-973B 是一种有效的别构激动剂和 α7 nAChR 的正向别构调节剂,可用于缓解疼痛的研究。 | |||
T9076 | Others | ||
Spinosad 是在土壤细菌 S. spinosa 中发现的一种杀虫剂,是大环内酯多杀菌素 A 和多杀菌素 D 的混合物,可作为昆虫烟碱乙酰胆碱酯酶受体 (nAChRs) 的激动剂。它具有优良的环境和哺乳动物毒理学特征,以及杀灭幼虫的活性。 | |||
T2422 | AChR | ||
PNU 282987 是一种选择性 α7 烟碱型乙酰胆碱受体 (α7 nAChR) 激动剂,Ki 为 26 nM。 | |||
T1594 | AChR | ||
Vecuronium bromide (ORG NC 45) 是一种合成的中效单季铵盐类固醇和非去极化神经肌肉阻滞剂,具有肌肉松弛活性。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPH-03037 | Alpha-cobratoxin Protein, Naja kaouthia, Recombinant (GST & His & Myc) | Naja kaouthia | E. coli | ||
Monomer: binds with high affinity to muscular (alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND) nAChR (tested on Torpedo californica, Kd=0.2-4.5 nM) and neuronal alpha-7/CHRNA7 nicotinic acetylcholine receptors (Kd=13-105 nM). Also inhibits GABA(A) channels. Heteropentamer targets studied are composed of alpha-1-beta-3-gamma-2 (GABRA1-GABRB3-GABRG2) subunits (IC(50)=236 nM), alpha-1-beta-2-gamma-2 (GABRA1-GABRB2-GABRG2) subunits (IC(50)=469 nM), alpha-2-beta-2-gamma-2 (GABRA2-GABRB2-GABRG2) subunits (IC(50)=485 nM), alpha-5-beta-3-gamma-2 (GABRA5-GABRB3-GABRG2) subunits (IC(50)=635 nM), and alpha-2-beta-3-gamma-2 (GABRA2-GABRB3-GABRG2) subunits (IC(50)=1099 nM) (activated by 10 uM GABA).; Homodimer: binds with high affinity (but lower than the monomeric form) to muscular (IC(50)=9.7 nM) and with low affinity to neuronal alpha-7/CHRNA7 nAChRs (IC(50)=1370 nM). However, it acquires (compared to the monomeric form) the capacity to block alpha-3/beta-2 (CHRNA3/CHRNB2) nAChRs.; Heterodimer with cytotoxin 3 (AC P01446): is slightly more active than the homodimer in inhibiting alpha-7/CHRNA7 nAChR and is considerably more active in blocking the alpha-3-beta-2/CHRNA3-CHRNB2 nAChR.
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TMPH-03219 | Rabies virus (RABV) (strain India) Glycoprotein (His) | RABV | Yeast | ||
Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells.
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TMPH-03220 | Rabies virus (RABV) (strain India) Glycoprotein (His & SUMO) | RABV | E. coli | ||
Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells.
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TMPH-03224 | Rabies virus (RABV) (strain HEP-Flury) Glycoprotein (E. coli, His) | RABV | E. coli | ||
Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells.
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TMPH-03222 | Rabies virus (RABV) (strain ERA) Glycoprotein (His) | RABV | E. coli | ||
Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells.
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TMPH-03223 | Rabies virus (RABV) (strain HEP-Flury) Glycoprotein (His) | RABV | Baculovirus | ||
Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells.
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TMPH-03221 | Rabies virus (RABV) (strain CVS-11) Glycoprotein (His & Myc & SUMO) | RABV | E. coli | ||
Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells.
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