目录号 | 产品详情 | 靶点 | |
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T1459 | Adrenergic Receptor AChR Autophagy | ||
Cisatracurium besylate (51W89) 是一种用于静脉内给药的非去极化骨骼肌松弛剂。 | |||
T23348 | AChR | ||
SEN12333 是强选择性和口服活性的 α7 nAChR 激动剂,可以用于 AD 和精神分裂症研究。它在功能性 Ca2+通量研究中起到完全激动剂的作用,对 GH4C1 细胞中表达的大鼠 α7 nAChRs 具有很高的亲和性。 | |||
T0479 | AChR | ||
Cytisinicline (Sophorine) 是从染料木中提取的一种生物碱,可用于帮助戒烟。它是 α4β2 烟碱乙酰胆碱能受体的部分激动剂,也是含 β4 受体和 α7 受体的偏完全性激动剂。 | |||
TN1643 | PAFR AChR | ||
Ferulamide (4-Hydroxy-3-methoxycinnamide) 是从巴豆中分离的阿魏酸衍生物,具有抗胆碱酯酶活性。 | |||
T0818 | AChR AChE | ||
Decamethonium bromide (Syncurine) 是神经肌肉阻滞剂和烟碱型 AChR 部分激动剂。 | |||
T0395 | Antibiotic Parasite | ||
Pyrantel tartrate (Banminth) 是一种四氢嘧啶类广谱牲畜驱虫剂,是烟碱乙酰胆碱受体激动剂。它能引起寄生虫的痉挛性肌肉麻痹。它可研究胃肠道线虫感染。 | |||
T7884 | AChR | ||
NS 1738 (NSC-213859) 是含有 α7 的神经元烟碱乙酰胆碱受体 (nAChRs) 的正变构调节剂。在卵母细胞实验中,正调节 α7nAChR,EC50为 3.4 μM。 | |||
T1259 | Others Antibiotic Parasite | ||
Pyrantel pamoate (Pyrantel embonate) 是一种四氢嘧啶光谱驱虫剂,是烟碱乙酰胆碱受体激动剂。它可引起寄生虫的痉挛性肌肉麻痹。它可研究胃肠道线虫感染。 | |||
T0166 | AChR | ||
Pancuronium dibromide (Pavulon) 是一种双季基类固醇,是一种神经肌肉松弛剂。它通过与乙酰胆碱竞争 nACh 受体上的结合位点来抑制神经肌肉传递。它还可抑制心脏毒蕈碱受体并具有拟交感神经作用。 | |||
T7695 | AChR | ||
PNU-282987 S enantiomer free base 是 PNU-282987 的 S 型对映体,是 α7 烟碱乙酰胆碱受体的激动剂。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPH-00430 | VxXIIC Protein, Conus vexillum, Recombinant (His & Myc & SUMO) | Conus vexillum | E. coli | ||
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin specifically blocks mammalian neuronal nAChR of the alpha-7/CHRNA7, alpha-3-beta-2/CHRNA3-CHRNB2 and alpha-4-beta-2/CHRNA4-CHRNB2 subtypes. VxXXA and VxXXB inhibit alpha-7/CHRNA7 and alpha-3-beta-2/CHRNA3-CHRNB2 nAChR more efficiently than VxXXC. VxXXB is the most effective at inhibiting alpha-4-beta-2/CHRNA4-CHRNB2 nAChR, followed by VxXXC and VxXXA. VxXIIC Protein, Conus vexillum, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 25.3 kDa and the accession number is P0C1W7.
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TMPH-03037 | Alpha-cobratoxin Protein, Naja kaouthia, Recombinant (GST & His & Myc) | Naja kaouthia | E. coli | ||
Monomer: binds with high affinity to muscular (alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND) nAChR (tested on Torpedo californica, Kd=0.2-4.5 nM) and neuronal alpha-7/CHRNA7 nicotinic acetylcholine receptors (Kd=13-105 nM). Also inhibits GABA(A) channels. Heteropentamer targets studied are composed of alpha-1-beta-3-gamma-2 (GABRA1-GABRB3-GABRG2) subunits (IC(50)=236 nM), alpha-1-beta-2-gamma-2 (GABRA1-GABRB2-GABRG2) subunits (IC(50)=469 nM), alpha-2-beta-2-gamma-2 (GABRA2-GABRB2-GABRG2) subunits (IC(50)=485 nM), alpha-5-beta-3-gamma-2 (GABRA5-GABRB3-GABRG2) subunits (IC(50)=635 nM), and alpha-2-beta-3-gamma-2 (GABRA2-GABRB3-GABRG2) subunits (IC(50)=1099 nM) (activated by 10 uM GABA).; Homodimer: binds with high affinity (but lower than the monomeric form) to muscular (IC(50)=9.7 nM) and with low affinity to neuronal alpha-7/CHRNA7 nAChRs (IC(50)=1370 nM). However, it acquires (compared to the monomeric form) the capacity to block alpha-3/beta-2 (CHRNA3/CHRNB2) nAChRs.; Heterodimer with cytotoxin 3 (AC P01446): is slightly more active than the homodimer in inhibiting alpha-7/CHRNA7 nAChR and is considerably more active in blocking the alpha-3-beta-2/CHRNA3-CHRNB2 nAChR.
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TMPH-03219 | Rabies virus (RABV) (strain India) Glycoprotein (His) | RABV | P. pastoris (Yeast) | ||
Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. Rabies virus (RABV) (strain India) Glycoprotein (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 51.4 kDa and the accession number is A3RM22.
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TMPH-03224 | Rabies virus (RABV) (strain HEP-Flury) Glycoprotein (E. coli, His) | RABV | E. coli | ||
Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. Rabies virus (RABV) (strain HEP-Flury) Glycoprotein (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 55.5 kDa and the accession number is P19462.
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TMPH-03220 | Rabies virus (RABV) (strain India) Glycoprotein (His & SUMO) | RABV | E. coli | ||
Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. Rabies virus (RABV) (strain India) Glycoprotein (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 65.4 kDa and the accession number is A3RM22.
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TMPH-03222 | Rabies virus (RABV) (strain ERA) Glycoprotein (His) | RABV | E. coli | ||
Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. Rabies virus (RABV) (strain ERA) Glycoprotein (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 55.0 kDa and the accession number is P03524.
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TMPH-03221 | Rabies virus (RABV) (strain CVS-11) Glycoprotein (His & Myc & SUMO) | RABV | E. coli | ||
Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. Rabies virus (RABV) (strain CVS-11) Glycoprotein (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 69.7 kDa and the accession number is O92284.
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TMPH-03223 | Rabies virus (RABV) (strain HEP-Flury) Glycoprotein (His) | RABV | Baculovirus Insect Cells | ||
Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. Rabies virus (RABV) (strain HEP-Flury) Glycoprotein (His) is expressed in Baculovirus insect cells with C-9xHis tag. The predicted molecular weight is 51.5 kDa and the accession number is P19462.
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