目录号 | 产品详情 | 靶点 | |
---|---|---|---|
T7208 | HIV Protease CXCR | ||
AMD 3465 hexahydrobromide (GENZ-644494 (hexahydrobromide)) 是一种 CXCR4受体拮抗剂,具有潜在的抗癌和抗 HIV 活性。 | |||
T10906 | Others | ||
CXCR7 modulator 1 is an effective and orally bioavailable peptoid hybrid CXCR7 modulator with Ki of 9 nM. | |||
T33763 | |||
NVP CXCR2 20 is an effective selective CXCR2 antagonist (IC50 = 40 nM) with oral bioavailability. | |||
T10907 | Others | ||
CXCR7 modulator 2 is a 7-type C-X-C chemokine receptor (CXCR7) modulator with a Ki of 13 nM. | |||
T78879 | CXCR | ||
CXCR4-IN-2(compound A1)是一款具有抗癌活性的双功能氟化小分子,是CXCR4的强效抑制剂。它对小鼠结直肠癌(CRC)细胞展现出显著的细胞毒性(IC50:60 μg/mL;72小时)和抗增殖能力,能够引导细胞在G2/M期发生阻滞并诱导细胞凋亡(apoptosis)。 | |||
T61420 | |||
CXCR4 antagonist 6 (compound 46) is a highly potent inhibitor of CXCR4 with an IC50 value of 79 nM. It effectively inhibits the cytosolic calcium flux induced by CXCL12, achieving an IC50 of 0.25 nM. Moreover, CXCR4 antagonist 6 demonstrates significant mitigation of cell migration mediated by the CXCL12/CXCR4 interaction. Notably, this compound exhibits remarkable efficacy in a mouse model of cancer metastasis [1]. | |||
T79059 | CXCR | ||
CXCR4-IN-1 (Example C5) 为CXCR4抑制剂,IC50值为20 nM。该化合物主要适用于癌症、HIV、糖尿病视网膜病变、炎症等领域的研究。 | |||
T61236 | |||
CXCR2 antagonist 7 (compound 19) 是一种有效的CXCR2拮抗剂。CXCR2 antagonist 7 显示出有效的CXCR2结合亲和力 (IC50=0.044 μM) 和钙动员 (IC50=0.66 μM)。 | |||
T63369 | |||
CXCR4 antagonist 4 是口服具有活力的、有效的CXCR4拮抗剂,IC50 值为 24 nM。CXCR4 antagonist 4能够抑制 CYP 2D6 的活性,增加 PAMPA 的通透性,有效阻碍人类免疫缺陷病毒的进入 (IC50=7 nM)。 | |||
T61363 | |||
CXCR4 antagonist 8 (Compound 3) is a potent inhibitor of CXCR4. It demonstrates an IC50 value of 57 nM in CXCR4 antagonism. In addition, it effectively inhibits the increase in cytosolic calcium induced by CXCL12 with an IC50 value of 0.24 nM. Furthermore, Compound 3 shows efficacy in the inhibition of CXCL12/CXCR4-mediated cell migration [1]. |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
---|---|---|---|---|---|
TMPH-02612 | CXCR3 Protein, Mouse, Recombinant (His & KSI) | Mouse | E. coli | ||
Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Probably promotes cell chemotaxis response. Binds to CCL21.
|
|||||
TMPH-01162 | CXCR3 Protein, Human, Recombinant (GST & His) | Human | E. coli | ||
CXCR3 Protein, Human, Recombinant (GST & His) is expressed in E. coli.
|
|||||
TMPY-06553 | CXCR4 Protein, Human, Recombinant | Human | HEK293 | ||
CXCR4 Protein, Human, Recombinant is expressed in HEK293. The predicted molecular weight is 39.75 kDa. Accession number: P61073-1
|
|||||
TMPJ-01037 | CXCR4 Protein, Human, Recombinant (hFc) | Human | Human Cells | ||
C-X-C chemokine receptor type 4 (CXCR4) is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. This receptor is one of several chemokine receptors that HIV isolates can use to infect CD4+ T cells. CXCR4 stands out for its pleiotropic roles in both physiological and pathological conditions and it represents a crucial target in drug development. CXCL12 is the principal CXCR4 specific ligand and that the pro-inflammatory chemokine macrophage migration inhibitory factor (MIF) is also able to bind and activate CXCR4.
|
|||||
TMPJ-00760 | CXCL7 Protein, Human, Recombinant | Human | E. coli | ||
Human Chemokine (C-X-C motif) Ligand 7 (CXCL7), also known as neutrophil activating peptide 2 (NAP-2), is a member of the CXC chemokines containing an ELR domain (Glu-Leu-Arg tripeptide motif). Similar to other ELR domain containing CXC chemokines, such as IL-8 and the GRO proteins, CXCL7 binds CXCR2, chemoattracts and activates neutrophils. CXCL7, Connective Tissue Activating Protein III (CTAPIII) and βthrombogulin (βTG), are proteolytically processed carboxylterminal fragments of platelet basic protein (PBP) which is found in the alphagranules of human platelets. Although CTAPIII, βTG, and PBP represent amino-terminal extended variants of NAP2 and possess the same CXC chemokine domains, these proteins do not exhibit CXCL7/NAP2 activity. CXCL7 induces cell migration through the G-protein-linked receptor CXCR-2.
|