目录号 | 产品详情 | 靶点 | |
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T62007 | |||
CXCR4 modulator-1 (compound ZINC72372983) 是有效的CXCR4调节剂(EC50= 100 nM)。CXCR4 modulator-1 在抗炎、抗癌及抗 HIV 感染方面有研究价值。 | |||
T62352 | |||
CXCR4 modulator-2 (compound Z7R) 是一种 CXCR4 的高效调节剂 (IC50: 1.25 nM)。CXCR4 modulator-2 在小鼠血清中表现出较好的稳定性 (t1/2= 77.1 min),在小鼠水肿模型中具有抗炎作用。 | |||
T61447 | |||
CXCR2 antagonist 4 (compound 7) is a highly potent antagonist that inhibits CXCR2 with an IC50 value of 0.13 μM. It also effectively inhibits the cytosolic calcium increase induced by CXCL8, with an IC50 value of 27 μM. CXCR2 antagonist 4 shows promising potential for anticancer research [1]. | |||
T61235 | |||
CXCR2 antagonist 5 (compound 25) 是一种有效的CXCR2拮抗剂。 CXCR2 antagonist 5 显示出有效的CXCR2结合亲和力 (IC50=0.013 μM) 和钙动员 (IC50=0.1 μM)。 | |||
T61650 | |||
CXCR4 antagonist 9 (Compound 2) is a potent CXCR4 antagonist displaying an IC50 of 15 nM. It effectively inhibits the cytosolic calcium increase induced by CXCL12, with an IC50 value of 1.3 nM [1]. | |||
T61386 | |||
CXCR2 antagonist 2 是一种有效的癌症免疫治疗的 CXCR2拮抗剂,IC50值为 95 nM。 | |||
T60811 | |||
CXCR4 antagonist 7 (Compound PARA-B) 是可用于研究HIV 感染、炎症性疾病、癌症和 WHIM 综合症的CXCR4拮抗剂 (IC50 = 9.3 nM)。 | |||
T62325 | |||
CXCR7 antagonist-1 hydrochloride 是一种 CXCR7 拮抗剂,对 SDF-1 趋化因子(也称为 CXCL12 趋化因子)或 I-TAC(也称为 CXCL11)与趋化因子受体 CXCR7 结合具有抑制作用。CXCR7 antagonist-1 hydrochloride 能够用于肿瘤细胞增殖,肿瘤形成,炎症疾病和许多其他疾病的预防。 | |||
T1776L | Virus Protease HIV Protease CXCR | ||
Plerixafor octahydrochloride (JM3100 octahydrochloride) 是一种选择性的CXCR4拮抗剂,IC50为 44 nM。Plerixafor 是一种具有造血干细胞动员活性的双环霉素。 | |||
T27791 | |||
Ladarixin Sodium, an Chemokine CXCR antagonist, is used potentially for the treatment of type I diabetes. |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPH-02612 | CXCR3 Protein, Mouse, Recombinant (His & KSI) | Mouse | E. coli | ||
Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Probably promotes cell chemotaxis response. Binds to CCL21.
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TMPH-01162 | CXCR3 Protein, Human, Recombinant (GST & His) | Human | E. coli | ||
CXCR3 Protein, Human, Recombinant (GST & His) is expressed in E. coli.
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TMPY-06553 | CXCR4 Protein, Human, Recombinant | Human | HEK293 Cells | ||
CXCR4 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 39.75 kDa and the accession number is P61073-1.
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TMPJ-01037 | CXCR4 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
C-X-C chemokine receptor type 4 (CXCR4) is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. This receptor is one of several chemokine receptors that HIV isolates can use to infect CD4+ T cells. CXCR4 stands out for its pleiotropic roles in both physiological and pathological conditions and it represents a crucial target in drug development. CXCL12 is the principal CXCR4 specific ligand and that the pro-inflammatory chemokine macrophage migration inhibitory factor (MIF) is also able to bind and activate CXCR4.
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TMPJ-00760 | CXCL7 Protein, Human, Recombinant | Human | E. coli | ||
Human Chemokine (C-X-C motif) Ligand 7 (CXCL7), also known as neutrophil activating peptide 2 (NAP-2), is a member of the CXC chemokines containing an ELR domain (Glu-Leu-Arg tripeptide motif). Similar to other ELR domain containing CXC chemokines, such as IL-8 and the GRO proteins, CXCL7 binds CXCR2, chemoattracts and activates neutrophils. CXCL7, Connective Tissue Activating Protein III (CTAPIII) and βthrombogulin (βTG), are proteolytically processed carboxylterminal fragments of platelet basic protein (PBP) which is found in the alphagranules of human platelets. Although CTAPIII, βTG, and PBP represent amino-terminal extended variants of NAP2 and possess the same CXC chemokine domains, these proteins do not exhibit CXCL7/NAP2 activity. CXCL7 induces cell migration through the G-protein-linked receptor CXCR-2.
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