目录号 | 产品详情 | 靶点 | |
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T61409 | |||
CXCR4 antagonist 3 (compound 12a), an effective antagonist of CXCR4, exhibits an IC50 of 11 nM. It is a congener of TIQ15, showcasing exceptional properties such as CXCR4 antagonism, CYP 2D6 inhibition, metabolic stability, and permeability. With its potential for research on the human immunodeficiency virus, CXCR4 antagonist 3 holds great promise [1]. | |||
T0617 | c-Myc Endogenous Metabolite CXCR Drug Metabolite | ||
Nicotinamide N-oxide (Nicotinamide 1-oxide) 是生物体内烟酰胺分解代谢物,是高效选择性CXCR2受体拮抗剂。 | |||
T61356 | |||
CXCR2 antagonist 3 (compound 11h) is a highly effective antagonist of CXC chemokine receptor 2 (CXCR2). It displays potent activity in inhibiting neutrophil infiltration into the air pouch, with double-digit nanomolar potencies against CXCR2. Moreover, CXCR2 antagonist 3 reduces the infiltration of neutrophils and MDSCs, while enhancing the infiltration of CD3+ T lymphocytes into Pan02 tumor tissues [1]. | |||
T60696 | |||
CXCR2 antagonist 8 是可用于研究胰岛素抵抗的,CXCR2受体的选择性拮抗剂。 | |||
T64306 | |||
CXCR4 probe 1 (compound 5) 是一种有效地、特异性的 CXCR4 靶向 PET 示踪剂,能够作用于 CXCR4 特异性拮抗剂 TN14003 (IC50: 6.9 nM)。CXCR4 probe 1 具有潜力作为 CXCR4 特异性成像探针,用于炎性疾病、CXCR4 阳性肿瘤和转移性肿瘤的诊断和预后监测。 | |||
T62007 | |||
CXCR4 modulator-1 (compound ZINC72372983) 是有效的CXCR4调节剂(EC50= 100 nM)。CXCR4 modulator-1 在抗炎、抗癌及抗 HIV 感染方面有研究价值。 | |||
T6764 | CXCR | ||
ATI-2341 是 C-X-C 趋化因子受体 4 型功能选择性变构激动剂,作为偏向配体有利于 Gα1 激活。它是一种变构激动剂,可激活抑制性异源三聚体 G 蛋白 (Gi) 以促进抑制 cAMP 产生并诱导钙动员。 | |||
T61419 | |||
CXCR4 antagonist 5 (compound 23), a potent CXCR4 antagonist, exhibits high inhibition efficacy against CXCR4 with an IC50 value of 8.8 nM. It effectively suppresses CXCL12-induced cytosolic calcium increase (IC50 = 0.02 nM) and hinders CXCR4/CXCL12-mediated chemotaxis. Moreover, Compound 23 demonstrates favorable physicochemical properties and in vitro safety profiles, exhibiting only marginal to moderate inhibition of CYP isozymes and hERG [1]. | |||
T61359 | |||
CXCR2 antagonist 6 (compound 35c) 是一种有效的CXCR2拮抗剂。CXCR2 antagonist 6 显示出有效的CXCR2结合亲和力 (IC50=0.43 μM) 和钙动员 (IC50=0.11 μM)。 | |||
T80216 | CXCR | ||
DOTA-CXCR4-L为针对CXCR4的靶向肽,适用于癌症研究,如胶质母细胞瘤和三阴性乳腺癌。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPH-02612 | CXCR3 Protein, Mouse, Recombinant (His & KSI) | Mouse | E. coli | ||
Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Probably promotes cell chemotaxis response. Binds to CCL21.
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TMPH-01162 | CXCR3 Protein, Human, Recombinant (GST & His) | Human | E. coli | ||
CXCR3 Protein, Human, Recombinant (GST & His) is expressed in E. coli.
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TMPY-06553 | CXCR4 Protein, Human, Recombinant | Human | HEK293 | ||
CXCR4 Protein, Human, Recombinant is expressed in HEK293. The predicted molecular weight is 39.75 kDa. Accession number: P61073-1
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TMPJ-01037 | CXCR4 Protein, Human, Recombinant (hFc) | Human | Human Cells | ||
C-X-C chemokine receptor type 4 (CXCR4) is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. This receptor is one of several chemokine receptors that HIV isolates can use to infect CD4+ T cells. CXCR4 stands out for its pleiotropic roles in both physiological and pathological conditions and it represents a crucial target in drug development. CXCL12 is the principal CXCR4 specific ligand and that the pro-inflammatory chemokine macrophage migration inhibitory factor (MIF) is also able to bind and activate CXCR4.
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TMPJ-00760 | CXCL7 Protein, Human, Recombinant | Human | E. coli | ||
Human Chemokine (C-X-C motif) Ligand 7 (CXCL7), also known as neutrophil activating peptide 2 (NAP-2), is a member of the CXC chemokines containing an ELR domain (Glu-Leu-Arg tripeptide motif). Similar to other ELR domain containing CXC chemokines, such as IL-8 and the GRO proteins, CXCL7 binds CXCR2, chemoattracts and activates neutrophils. CXCL7, Connective Tissue Activating Protein III (CTAPIII) and βthrombogulin (βTG), are proteolytically processed carboxylterminal fragments of platelet basic protein (PBP) which is found in the alphagranules of human platelets. Although CTAPIII, βTG, and PBP represent amino-terminal extended variants of NAP2 and possess the same CXC chemokine domains, these proteins do not exhibit CXCL7/NAP2 activity. CXCL7 induces cell migration through the G-protein-linked receptor CXCR-2.
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