目录号 | 产品详情 | 靶点 | |
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T74467 | |||
Remdesivir de(ethylbutyl 2-aminopropanoate) 是 Remdesivir 的一种杂质,后者为一种具有抗病毒活性的核苷类似物。在 HAE 细胞针对 SARS-CoV 和 MERS-CoV 的实验中,Remdesivir 的 EC50 值为 74 nM;在针对鼠肝炎病毒的延迟脑肿瘤细胞实验中,其 EC50 值为 30 nM。此外,Remdesivir 亦被认为具有针对 2019-nCoV (COVID-19) 的研究潜力。 | |||
T83819 | |||
2’-O-甲基鸟苷-5'-O-三磷酸(2’-methyl GTP)作为丙肝病毒(HCV)非结构蛋白5B(NS5B;IC50 = 3.5 µM)的抑制剂,同时是前药IDX184的活性代谢产物,通过2’-methylguanosine中间体生成。在50 µM浓度下,2’-methyl GTP还能促进微管蛋白聚合。患有肝细胞癌的患者体内2’-methyl GTP水平,相比于邻近正常组织有所下降。 | |||
T83714 | |||
Lupus autoantigen peptide (LAP) 是源自La的一种抗病毒肽,La是系统性红斑狼疮 (SLE) 患者中发现的一种自身抗原,对应于La的11-28氨基酸。它抑制了丙型肝炎病毒 (HCV) 5’-UTR与内部核糖体进入位点 (IRES) 跨作用因子 (ITAFs),包括多嘧啶片段结合蛋白 (PTB) 和多聚(rC)-结合蛋白2 (PCBP2) 之间的相互作用。LAP (60 µM) 在使用Huh7细胞的报告者测定中抑制了HCV IRES介导的翻译,这一效应可以通过重组的PTB和PCBP2来逆转。 | |||
T38297 | |||
Ribavirin-13C5is intended for use as an internal standard for the quantification of ribavirin by GC- or LC-MS. Ribavirin is an antiviral guanosine nucleoside analog.1,2Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 μg/ml).3Ribavirin also reduces replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero cells (EC50= 109.5 μM).4Aerosol administration of ribavirin (30 mg/kg) reduces mortality in a mouse model of influenza A infection.5Formulations containing ribavirin have been used in the treatment of respiratory syncytial virus (RSV), hepatitis C virus (HCV), and viral hemorrhagic fevers. 1.Gilbert, B.E., and Knight, V.Biochemistry and clinical applications of ribavirinAntimicrob. Agents Chemother.30(2)201-205(1986) 2.Gordon, C.J., Tchesnokov, E.P., Woolner, E., et al.Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potencyJ. Biol. Chem.295(20)6785-6797(2020) 3.Kirsi, J.J., North, J.A., McKernan, P.A., et al.Broad-spectrum antiviral activity of 2-β-D-ribofuranosylselenazole-4-carboxamide, a new antiviral agentAntimicrob. Agents Chemother.24(3)353-361(1983) 4.Wang, M., Cao, R., Zhang, L., et al.Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitroCell Res.30(3)269-271(2020) 5.Wilson, S.Z., Knight, V., Wyde, P.R., et al.Amantadine and ribavirin aerosol treatment of influenza A and B infection in miceAntimicrob. Agents Chemother.17(4)642-648(1980) | |||
T36490 | |||
AZT triphosphate TFA (3'-Azido-3'-deoxythymidine-5'-triphosphate TFA) is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate TFA exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate TFA also inhibits the DNA polymerase of HBV. AZT triphosphate TFA activates the mitochondria-mediated apoptosis pathway[1][2][3]. Treatment with 100 μM Zidovudine (AZT) for 48h disrupts the mitochondrial tubular network via accumulation of AZT triphosphate (AZT-TP) in H9c2 cells. AZT triphosphate accumulation causes downregulation of Opa1 and upregulation of Drp1. AZT triphosphate causes mitochondrial dysfunction, increases the production of cytotoxic reactive oxygen species (ROS), and impairs the balance of the mitochondrial quality control system in H9c2 cell model established from rat embryonic myoblasts[1]. [1]. Ryosuke Nomura, et al. Azidothymidine-triphosphate Impairs Mitochondrial Dynamics by Disrupting the Quality Control System. Redox Biol. 2017 Oct;13:407-417. [2]. Takeya Sato, et al. Engineered Human tmpk/AZT as a Novel Enzyme/Prodrug Axis for Suicide Gene Therapy. Mol Ther. 2007 May;15(5):962-70. [3]. K Y Hostetler, et al. Enhanced Oral Absorption and Antiviral Activity of 1-O-octadecyl-sn-glycero-3-phospho-acyclovir and Related Compounds in Hepatitis B Virus Infection, in Vitro. Biochem Pharmacol. 1997 Jun 15;53(12):1815-22. | |||
T36881 | |||
NHC-triphosphate triammonium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a triphosphate form[1]. NHC-triphosphate triammonium is a weak alternative substrate for the viral polymerase and can be incorporated into HCV replicon RNA[1][2]. In an intracellular metabolism assay, HCV replicon cells are treated with 10 μM 3H-labeled NHC, and intracellular nucleotide levels are determined after 1, 2 and 8 hours incubations. NHC is rapidly convered into the mono-, di-, and triphosphate forms, and NHC-TP reaches up to 71.12 pM after 8 hours[1].NHC-triphosphate triammonium (NHC-TP) (5-40 μM) absence leads to full-length polymerization products, it can be a weak alternative substrate. In addition, incorporation of NHC-TP instead of CTP increases the molecular weight of the polymerization product by 16 (one extra oxygen) for each event and an obvious electrophoretic shift is observed in cell-free HCV NS5B polymerization reactions[1].Huh-7 cells are incubated with (10-50 μM; 4 h) NHC or a McGuigan phosphoramidate prodrug of NHC. Intracellular levels of the parental compounds and phosphorylated metabolites are measured using LC-MS/MS. Small amounts of NHC-monophosphate (MP) and NHC-diphosphate (DP) can be observed, while NHC-triphosphate triammonium remains the most abundant metabolite[2].NHC-triphosphate triammonium (NHC-TP) metabolite may directly target the viral polymerase and behave as a nonobligate chain terminator. It plays a prominent role in inhibiting early negative-strand RNA synthesis, either through chain termination or mutagenesis, which may in turn interfere with correct replicase complex formation. [1]. Stuyver LJ,et al. Ribonucleoside analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture.Antimicrob Agents Chemother. 2003 Jan;47(1):244-54. [2]. Maryam Ehteshami, et al. Characterization of β-d- N4-Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus. |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-05822 | Hepatitis B Virus (HBV)(ayw/France/Tiollais/1979) Capsid protein (His) | HBV-D | E. coli | ||
Hepatitis B virus (HBV) capsid assembly is a critical step in the propagation of the virus and is mediated by the core protein. The first cytoplasmic step in the formation of an infectious HBV virion is the formation of a capsid containing pregenomic RNA (pgRNA) and the viral polymerase (Pol). HBV capsid assembly is an attractive target for new antiviral therapies.
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TMPY-01621 | TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.3 kDa and the accession number is AAL65157.1.
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TMPY-05227 | TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 Cells | ||
TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21.3 kDa and the accession number is AAL65157.1.
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TMPH-00809 | Hepatitis C Genome polyprotein (His) | HCV | E. coli | ||
Hepatitis C Genome polyprotein (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 71.3 kDa and the accession number is S4UAW6.
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TMPY-01951 | TIM-1/KIM-1/HAVCR1 Protein, Rhesus, Recombinant | Rhesus | HEK293 Cells | ||
TIM-1/KIM-1/HAVCR1 Protein, Rhesus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 32.4 kDa and the accession number is BAJ61041.1.
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TMPY-01671 | TIM-1/KIM-1/HAVCR1 Protein, Rhesus, Recombinant (His) | Rhesus | HEK293 Cells | ||
TIM-1/KIM-1/HAVCR1 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15 kDa and the accession number is BAJ61041.1.
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TMPY-01350 | TIM-1/KIM-1/HAVCR1 Protein, Canine, Recombinant (His) | Canine | HEK293 Cells | ||
TIM-1/KIM-1/HAVCR1 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.6 kDa and the accession number is A0A8C0N5Y0.
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TMPY-01455 | TIM-1/KIM-1/HAVCR1 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
TIM-1/KIM-1/HAVCR1 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26.7 kDa and the accession number is O54947.
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TMPY-01317 | TIM-1/KIM-1/HAVCR1 Protein, Rat, Recombinant (His & hFc) | Rat | HEK293 Cells | ||
TIM-1/KIM-1/HAVCR1 Protein, Rat, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with hHis and Fc tag. The predicted molecular weight is 52.6 kDa and the accession number is O54947.
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TMPY-00553 | TIM-3/KIM-3/HAVCR2 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 Cells | ||
TIM-3/KIM-3/HAVCR2 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.4 kDa and the accession number is G7P6Q7.
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TMPY-04280 | TIM-1/KIM-1/HAVCR1 Protein, Canine, Recombinant (mFc) | Canine | HEK293 Cells | ||
TIM-1/KIM-1/HAVCR1 Protein, Canine, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 41.8 kDa and the accession number is A0A8C0N5Y0.
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TMPK-01501 | HLA-A*02:01&B2M&HBV (FLLTRILTI) Tetramer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells | ||
Hepatitis B virus (HBV), is the leading cause of liver diseases infecting an estimated 240 million persons worldwide. The HBV prevalence rates are variables between different countries, with an high level of endemicity in the south-eastern part of Europe. Seven main HBV-D subgenotypes have been described until now (D1-D7).
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TMPK-01491 | HLA-A*02:01&B2M&HBV (FLLTRILTI) Monomer Protein, Human, MHC (His & Avi), Biotinylated | Human | HEK293 Cells | ||
Hepatitis B virus (HBV), is the leading cause of liver diseases infecting an estimated 240 million persons worldwide. The HBV prevalence rates are variables between different countries, with an high level of endemicity in the south-eastern part of Europe. Seven main HBV-D subgenotypes have been described until now (D1-D7).
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TMPK-01492 | HLA-A*02:01&B2M&HBV (FLLTRILTI) Monomer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells | ||
Hepatitis B virus (HBV), is the leading cause of liver diseases infecting an estimated 240 million persons worldwide. The HBV prevalence rates are variables between different countries, with an high level of endemicity in the south-eastern part of Europe. Seven main HBV-D subgenotypes have been described until now (D1-D7).
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TMPY-03677 | TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39.9 kDa and the accession number is AAL65156.1.
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TMPY-03424 | TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20.3 kDa and the accession number is AAL65156.1.
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TMPY-01564 | Hepatitis C virus (HCV-1a) E2 Protein (His) | HCV | HEK293 Cells | ||
Hepatitis C virus (HCV-1a) E2 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32 kDa and the accession number is NP_751921.1.
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TMPH-00814 | Hepatitis E virus genotype 3 (HEV-3) Capsid protein (His) | HEV-3 | P. pastoris (Yeast) | ||
Major viral capsid protein that encapsidates the viral genome. Binds to the 5' end of the genomic RNA. Hepatitis E virus genotype 3 (HEV-3) Capsid protein (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 29.3 kDa and the accession number is Q9YLQ9.
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TMPY-01244 | TIM-1/KIM-1/HAVCR1 Protein, Mouse, Recombinant (His & hFc) | Mouse | HEK293 Cells | ||
TIM-1/KIM-1/HAVCR1 Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with hHis and Fc tag. The predicted molecular weight is 49 kDa and the accession number is Q3V033.
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TMPH-00812 | Hepatitis E virus genotype 1 (HEV-1) Protein ORF3 (His & SUMO) | HEV-1 | E. coli | ||
Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway. Acts also as a viroporin and forms ion conductive pores allowing viral particle release. Impairs the generation of type I interferon by downregulating host TLR3 and TLR7 as well as their downstream signaling pathways. Hepatitis E virus genotype 1 (HEV-1) Protein ORF3 (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 27.8 kDa and the accession number is O90299.
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TMPH-00811 | Hepatitis delta virus genotype I (HDV) Small delta antigen Protein (His & Myc) | HDV | P. pastoris (Yeast) | ||
Promotes both transcription and replication of genomic RNA. Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal. May interact with host RNA polymerase II thereby changing its template requirement from DNA to RNA. RNA pol II complex would then acts as an RNA-directed RNA polymerase, and transcribe and replicate HDV genome. Hepatitis delta virus genotype I (HDV) Small delta antigen Protein (His & Myc) is expressed in yeast with N-6xHis and C-Myc tag. The predicted molecular weight is 25.4 kDa and the accession number is P06934.
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TMPH-00810 | Hepatitis delta virus genotype I (HDV) Large delta antigen Protein (His & Myc) | HDV | P. pastoris (Yeast) | ||
Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal. Needs co-infection with hepatitis B virus to provide surface proteins, otherwise there is no packaging or budding. Packages the HDV ribonucleoprotein in hepatitis B virus empty particles. Interacts with both HDV genomic RNA and cytoplasmic tail of HBsAg. May inhibit viral RNA replication. Hepatitis delta virus genotype I (HDV) Large delta antigen Protein (His & Myc) is expressed in yeast with N-10xHis and C-Myc tag. The predicted molecular weight is 27.7 kDa and the accession number is P0C6L6.
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TMPH-00813 | Hepatitis E virus genotype 1 (HEV-1) Secreted protein ORF2 (His) | HEV-1 | Baculovirus Insect Cells | ||
Plays a role in the inhibition of host antibody-mediated neutralization without blocking viral cell entry.; Forms an icosahedral capsid with a T=1 symmetry and a 34 nm diameter. The capsid is composed of 60 copies linked to each other. Binds to the 5' end of the genomic RNA to mediate genome encapsidation. Binds to heparin surface proteoglycans (HSPGs) to mediate viral entry. Additionally, the interactions with host ASGR1 and ASGR2 facilitate viral infection of hepatocytes. Hepatitis E virus genotype 1 (HEV-1) Secreted protein ORF2 (His) is expressed in Baculovirus insect cells with N-10xHis tag. The predicted molecular weight is 71.3 kDa and the accession number is Q68985.
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TMPY-05463 | TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells | ||
TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 46.2 kDa and the accession number is Q8TDQ0-1.
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TMPY-00296 | Hepatitis C virus (HCV) (serotype 1c,isolate HC-G9) E2 Protein (His) | HCV | HEK293 Cells | ||
Hepatitis C virus (HCV) (serotype 1c,isolate HC-G9) E2 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.2 kDa and the accession number is BAA03581.1.
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TMPY-06296 | TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc & Avi), Biotinylated | Human | HEK293 Cells | ||
TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with hFc and Avi tag. The predicted molecular weight is 48.41 kDa and the accession number is Q8TDQ0-1.
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TMPY-05428 | TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 46.6 kDa and the accession number is Q8TDQ0-1.
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TMPY-05166 | Hepatitis C virus (HCV) (serotype 1b, isolate HC-J4) Envelope/E2 Protein (His) | HCV | HEK293 Cells | ||
Hepatitis C virus (HCV) (serotype 1b, isolate HC-J4) Envelope/E2 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.4 kDa and the accession number is AAC15723.1.
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TMPY-01768 | TIM-1/KIM-1/HAVCR1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
TIM-1/KIM-1/HAVCR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31.3 kDa and the accession number is AAC39862.1.
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TMPJ-00423 | TIM-1/KIM-1/HAVCR1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
TIM-1/KIM-1/HAVCR belongs to the immunoglobulin superfamily that cosisits 305 amino acid (aa). It is expressed by stimulated T-cells. TIM-1/KIM-1/HAVCR may play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4. And may have a role in kidney injury and repair. Belongs to the T-cell and airway phenotype regulator (Tapr) locus, a single chromosomal region that confers reduced T-helper type 2 responsiveness and protects against airway hyperactivity (AHR), the hallmark of human asthma.
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TMPY-01173 | TIM-1/KIM-1/HAVCR1 Protein, Human, Recombinant (aa 1-135, His) | Human | HEK293 Cells | ||
TIM-1/KIM-1/HAVCR1 Protein, Human, Recombinant (aa 1-135, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.8 kDa and the accession number is AAC39862.1.
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TMPY-01161 | TIM-1/KIM-1/HAVCR1 Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells | ||
TIM-1/KIM-1/HAVCR1 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with hHis and Fc tag. The predicted molecular weight is 57 kDa and the accession number is AAC39862.1.
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TMPY-00323 | Hepatitis C virus (HCV-1a) NS3 protease/helicase immunodominant region Protein (aa 1356-1459, GST) | HCV | E. coli | ||
HCV NS3 displays three enzymatic activities: serine protease, NTPase, and RNA helicase. HCV NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A, and NS5A-NS5B. HCV NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction, and likely RNA stable secondary structure in the template strand (By similarity). Cleaves and inhibits the host antiviral protein MAVS. NS3/NS4A complex also prevents phosphorylation of human IRF3, thus preventing the establishment of dsRNA induced antiviral state. One of the HCV proteases, NS3-4A serine protease, is a non-covalent heterodimer consisting of a catalytic subunit (the N-terminal one-third of NS3 protein) and an activating cofactor (NS4A protein) and is responsible for cleavage at four sites of the HCV polyprotein.
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TMPJ-00624 | TIM-3/KIM-3/HAVCR2 Protein, Marmoset, Recombinant (His) | Marmoset | HEK293 Cells | ||
TIM-3/KIM-3/HAVCR2 Protein, Marmoset, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 30-45 KDa and the accession number is F7I881.
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TMPY-04135 | Hepatitis C virus Envelope Glycoprotein E1/HCV-E1 (subtype 1b, strain HC-J4) Protein (His) | HCV | HEK293 Cells | ||
Hepatitis C virus Envelope Glycoprotein E1/HCV-E1 (subtype 1b, strain HC-J4) Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 18.7 kDa and the accession number is AAC15725.1.
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TMPJ-00599 | TIM-3/KIM-3/HAVCR2 Protein, Human, Recombinant (hFc & His) | Human | HEK293 Cells | ||
Hepatitis A virus cellular receptor 2(HAVCR2)is a single-pass type I membrane protein and it contains 1 Ig-like V-type (immunoglobulin-like) domain. The protein belongs to the immunoglobulin superfamily, and TIM family of proteins. The protein regulates macrophage activation. It inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. It may be also involved in T-cell homing and it is receptor for LGALS9. CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.
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TMPJ-00173 | TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-191, His) | Mouse | HEK293 Cells | ||
TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-191, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 30-50 KDa and the accession number is Q8VIM0.
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TMPJ-00174 | TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-193, His) | Mouse | HEK293 Cells | ||
TIM-3/KIM-3/HAVCR2 Protein, Mouse, Recombinant (aa 20-193, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 38-55 KDa and the accession number is Q8VIM0.
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TMPJ-01273 | ACY3 Protein, Human, Recombinant (His) | Human | E. coli | ||
Aspartoacylase 3, also known as ACY3, N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming), Acylase III, Aminoacylase-3, Aspartoacylase-2, Aspartoacylase-2, HCV core-binding protein 1 and ASPA2, is a member of the Aspartoacylase subfamily. ACY3 plays an important role in deacetylating mercapturic acids in kidney proximal tubules and acts on N-acetyl-aromatic amino acids.ACY3 is located in the cytoplasm of S2 and S3 proximal tubules and the apical domain of S1 proximal tubules. ACY3 protein is also expressed at low levels in stomach, testis, heart, brain, lung and liver, and may function as an HCV (Hepatitis C virus) core binding protein.
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TMPY-02285 | Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS2 Protein | H1N1 | E. coli | ||
Non-structural protein 2 (NS2) plays a crucial role in the hepatitis C virus (HCV) assembly. NS2 was predicted to be composed of three transmembrane (TM) segments. Hepatitis C virus (HCV) nonstructural protein 2 (NS2) is a hydrophobic, transmembrane protein that is required not only for NS2-NS3 cleavage but also for infectious virus production.NS2 protein is essential for hepatitis C virus (HCV) replication. NS2 protein was expressed and purified. Aptamers against NS2 protein were raised and antiviral effects of the aptamers were examined. The non-structural protein NS2, also called nuclear export protein, of influenza A virus contains a leucine-rich nuclear export signal that could guide viral ribonucleoproteins to cross the nuclear pore complex (NPC) and complete directional nucleocytoplasmic trafficking.
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TMPH-01548 | IFI6 Protein, Human, Recombinant (B2M & His) | Human | E. coli | ||
Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis. However, it has also been shown to have a pro-apoptotic activity. Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, which activation is required for entry of the virus into cells.
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TMPH-00848 | OASL Protein, Human, Recombinant (His) | Human | E. coli | ||
Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L. OASL Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 65.1 kDa and the accession number is Q15646.
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TMPH-01104 | Claudin-9 Protein-VLP, Human, Recombinant (His) | Human | HEK293 Cells | ||
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.; (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells. Claudin-9 Protein-VLP, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-10xHis tag. The predicted molecular weight is 24.2 kDa and the accession number is O95484.
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TMPH-01632 | MRC1 Protein, Human, Recombinant (His) | Human | E. coli | ||
Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.; (Microbial infection) Acts as phagocytic receptor for bacteria, fungi and other pathogens.; (Microbial infection) Acts as a receptor for Dengue virus envelope protein E.; (Microbial infection) Interacts with Hepatitis B virus envelope protein. MRC1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 69.9 kDa and the accession number is P22897.
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TMPH-01902 | DDX60 Protein, Human, Recombinant (His) | Human | E. coli | ||
Positively regulates DDX58/RIG-I- and IFIH1/MDA5-dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of DDX58/RIG-I to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV). DDX60 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.1 kDa and the accession number is Q8IY21.
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TMPY-02193 | GOLPH2/GOLM1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Golgi membrane protein 1, also known as Golgi membrane protein GP73, Golgi phosphoprotein 2, and GOLM1, is a protein that belongs to the GOLM1 / CASC4 family. GOLM1 is widely expressed. It is highly expressed in the colon, prostate, trachea, and stomach. It is expressed at a lower level in testis, muscle, lymphoid tissues, white blood cells, and spleen. It is predominantly expressed by cells of the epithelial lineage. GOLM1 is expressed at a low level in the normal liver. Expression significantly increases in virus (HBV, HCV) infected liver. Expression of GOLM1 does not increase in liver disease due to non-viral causes (alcohol-induced liver disease, autoimmune hepatitis). Increased expression in hepatocytes appears to be a general feature of advanced liver disease. In liver tissue from patients with adult giant-cell hepatitis (GCH), GOLM1 is strongly expressed in hepatocyte-derived syncytial giant cells. GOLM1 is constitutively expressed by biliary epithelial cells but not by hepatocytes.
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TMPY-02909 | ASGR2 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
ASGR2 is a subunit of the asialoglycoprotein receptor. Asialoglycoprotein receptor, also known as the Ashwell receptor, which is specific for desialylated (galactosyl-terminal) glycoproteins and is expressed exclusively in hepatic parenchymal cells. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. ASGR2 is a glycoprotein. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. ASGR2 is the less abundant minor subunit.
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TMPJ-00505 | Serpin A1 Protein, Human, Recombinant (aa 25-418, His) | Human | HEK293 Cells | ||
Serpin A1 is a prototype member of the Serpin superfamily of the serine protease inhibitors. As one of the most abundant proteinase inhibitors in the circulation, it is synthesized in hepatocytes, and to a lesser extent, in macrophages as well as intestinal epithelial cell lines and secreted as the abundant proteinase inhibitor in the circulation whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Point mutations in the native SerpinA1 variants result in Serpin A1 deficiency, and consequently lead to several clinical complications such as pulmonary emphysema, juvenile hepatitis, cirrhosis, and hepatocellular carcinoma. For example, the Z variants (Glu342 to Lys) forms intracellular inclusion bodies, is not secreted, and leads to a severe SerpinA1 deficiency. Accordingly, Serpin A1 deficiency in circulation is associated with emphysema or liver disease.
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TMPJ-00420 | CTLA-4 Protein, Mouse, Recombinant (Flag) | Mouse | HEK293 Cells | ||
Mouse Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule. Within the ECD, Mouse CTLA-4 shares 68% aa sequence identity with human. CTLA4 is similar to the T cell costimulatory protein CD28 since both of the molecules bind to CD80 and CD86 on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found inregulatory T cells and may play an important role in their functions. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA4. Genetic variations of CTLA4 have been associated with susceptibility to systemic lupus erythematosus(SLE), Gravesdisease(GRD), Celiac disease type3(CELIAC3) and Hepatitis B virus infection(HBVinfection).
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TMPH-02131 | SKP2 Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, YTHDF2, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-dependent manner, thereby regulating cell migration.; Through the ubiquitin-mediated proteasomal degradation of hepatitis C virus non-structural protein 5A, has an antiviral activity towards that virus.
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