T72119
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4-Chloro Trazodone hydrochloride 是 Trazodone hydrochloride 的异构体。Trazodone hydrochloride 是一种抗抑郁剂,属于血清素受体拮抗剂和再摄取抑制剂,用于研究焦虑症。 |
T68579
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Fluvoxamine acid is a medication which functions as a selective serotonin reuptake inhibitor (SSRI) and σ1 receptor agonist. Fluvoxamine is used primarily for the treatment of obsessive-compulsive disorder (OCD), and is also used to treat major depressive disorder (MDD), and anxiety disorders such as panic disorder and post-traumatic stress disorder (PTSD). |
T68386
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(R)-Duloxetine Hydrochloride is a napthalenyloxy-substituted amine used in binding studies of human serum albumin along with (S)-Duloxetine. Unlike its enantiomer, it is not a very effective dual serotonin and norepinephrine reuptake inhibitor (SNRI). |
T37684
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Anandamide (arachidonoyl ethanolamide; AEA) is an endogenous lipid with cannabinergic activity; along with 2-arachidonoyl glycerol, it forms part of the endocannabinoid system. AEA undergoes reuptake into neurons by a facilitated process. Controversy exists as to whether there is a specific AEA transporter, or instead the uptake process is simply driven by hydrolysis of AEA by intracellular fatty acyl amide hydrolase (FAAH). CAY10412 is an analog of AEA that has no intrinsic binding affinity for either CB1 or CB2 receptors. It is a potent inhibitor of AEA reuptake in U937 lymphoma cells, with an IC50 of 3 μM. CAY10412 could be a useful tool for distinguishing the competing transporter theories. The pharmacology of CAY10412 is largely unexplored; it may enhance endocannabinoid signalling by augmenting endocannabinoid concentrations. |
T61741
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Pipofezine(Azafen,Azaphen)是5-羟色胺重吸收抑制剂。 |
TMIH-0159
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Citalopram-d6 是 Citalopram 的氘代化合物。Citalopram 的 CAS 号为 59729-33-8。Citalopram (Lu 10-171) 是一种具有口服活性的、选择性的血清素再摄取抑制剂 (SSRI),是一种选择性5-羟色胺再摄取抑制剂,是一种 S(+)-对映体 (Escitalopram) 和 R(-)-对映体的外消旋混合物。Citalopram 具有抗抑郁活性,可增强血清素能神经传递,可用于研究老年痴呆。 |
T11113
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Others
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Duloxetine D3 hydrochloride is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD).Duloxetine D3 hydrochloride ((S)-Duloxetine D3 hydrochloride) i |
T60508
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(S)-Venlafaxine 是 Venlafaxine 的(S)-构型。Venlafaxine 是一种具有口服活性的 5-羟色胺 (5-HT)/去甲肾上腺素 (NE) 再摄取双重抑制剂, 具有抗抑郁活性。 |
T69991
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Difenamizole HCl is the salt form of Difenamizole, a non-steroidal anti-inflammatory drug (NSAID) and analgesic of the pyrazolone group related to metamizole. It has monoaminergic properties, including inhibition of monoamine oxidase, augmentation of pargyline-induced elevation of striatal dopamine levels, inhibition of K+-induced striatal dopamine release, and inhibition of the reuptake of dopamine. |
T13330L
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transporter
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WAY-213613 是选择性非底物再摄取GLT-1/EAAT2抑制剂,对 EAAT2 的IC50为 85 nM。它对 EAAT1 和 EAAT3 的选择性是 59 倍和 44 倍,IC50分别为 5 和 3.8 μM。它是阐明 EAAT2 功能的潜在工具。 |