T39281
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AM404 is a chemical compound that functions as an inhibitor of endocannabinoid reuptake. It effectively blocks the transport of anandamide, with IC50 values measured in the low micromolar range. Moreover, AM404 exhibits the ability to induce relaxation in rat isolated hepatic arteries contracted with Phenylephrine. This relaxation effect is quantified by a pEC50 value of 7.4 (corresponding to an EC50 of 0.04 μM). Additionally, AM404 possesses a neuroprotective effect. |
T60445
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Desipramine 是一种具有抗抑郁活性的三环类化合物。Desipramine 可抑制中枢神经系统的去甲肾上腺素再摄取受体,减少睡眠相关的腮舌肌活性丧失,可用于改善咽塌陷的研究。 |
T60509
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Maprotiline 能够抑制细胞的增殖和转移,具有抗癌作用。 Maprotiline 通过靶向 ERK 信号通路和 CRABP1 诱导癌细胞凋亡。 Maprotiline 是一种高度选择性的去甲肾上腺素再摄取阻滞剂,具有有效的抗抑郁作用 [1][2]。 |
TMIH-0001
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(+/-)-Venlafaxine-d6 HCl 是 (+/-)-Venlafaxine HCl 的氘代化合物。(+/-)-Venlafaxine HCl 的 CAS 号为 99300-78-4。Venlafaxine hydrochloride 是一种口服有效的 5-羟色胺 (5-HT)/去甲肾上腺素 (NE) 重摄取的双重抑制剂,具有抗抑郁活性。 |
T65390
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Fluvoxketone is trifluoromethyl-substituted aryl ketone compound useful as an intermediate in the synthesis of Fluvoxamine, which is a selective serotonin reuptake inhibitor. In the synthesis of Fluvoxamine, the ketone carbonyl of Fluvoxketone is elaborated to an oxime.In vitro,the inhibitory effect of fluvoxamine on actin polymerization was concentration dependent, and its IC50 was approximately 30 μM.In vivo,fluvoxamine treated EAE rats showed a decrease in IFN-γ serum levels and an increase in IL-4, pro- and anti-inflammatory cytokines respectively. |
T70914
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GBR-12935 is a potent and selective dopamine reuptake inhibitor. It was originally developed in its 3H radiolabelled form for the purpose of mapping the distribution of dopaminergic neurons in the brain by selective labelling of dopamine transporter proteins. This has led to potential clinical uses in the diagnosis of Parkinson's disease, although selective radioligands such as Ioflupane (¹²³I) are now available for this application. GBR-12935 is now widely used in animal research into Parkinson's disease and the dopamine pathways in the brain. (Source: http://en.wikipedia.org/wiki/GBR-12935). |
T37167
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Reduced haloperidol is an active metabolite of haloperidol . It is formed via reduction of haloperidol by ketone reductase. Reduced haloperidol inhibits radioligand binding to sigma-1 and dopamine D2 receptors (Kis = 1.4 and 31 nM, respectively) and stimulates brain-derived neurotrophic factor (BDNF) secretion from CCF-SSTG1 and U87MG astrocytic glial cells. It also inhibits norepinephrine, dopamine, and serotonin (5-HT) reuptake (Kis = 21, 25, and 33 μM, respectively, in COS-7 cells expressing the human transporters). Reduced haloperidol (0.5 mg/kg) increases latency to paw withdrawal in mouse models of capsaicin- but not force-induced mechanical hypersensitivity. |
T71772
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Bicifadine, also known as DOV-220075, CL 220,075, is a SNDR inhibitor potentially for the treatment of lower back pain. Bicifadine has a non-opioid, non-NSAID mechanism for the treatment of pain, which should have less abuse potential than opioid drugs and less propensity to cause gastric ulcers than NSAID drugs. While the drug is purported to be a serotonin (SERT) and noradrenaline transporter (NET) inhibitor, it also has effects at the dopamine transporter (DAT), effectively making it a broad-spectrum monoamine transporter inhibitor or triple reuptake inhibitor."" |
T60521
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作为三环类抗抑郁药,Doxepin 抑制血清素和去甲肾上腺素的再摄取。Doxepin 具有抗炎作用,可减少抗氧化应激。Doxepin 显示出对特应性皮炎和慢性荨麻疹的治疗效果,并且能改善认知过程和保护中枢神经系统。 |
T72209
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(R,R)-Reboxetine mesylate 是一种抗抑郁药,具有良好的生物利用度。(R,R)-Reboxetine 为 Reboxetine 的对映体之一,属于选择性去甲肾上腺素再摄取抑制剂。Reboxetine 本身包含 (R,R) 与 (S,S) 两种对映体,且对 α-肾上腺素能和毒蕈碱受体的亲和力较低,表现出较低的动物毒性。 |