T71537
|
|
|
|
Tofenacin hydrochloride is an antidepressant drug with a tricyclic-like structure. It acts as a serotonin-norepinephrine reuptake inhibitor, and based on its close relation to orphenadrine, may also possess anticholinergic and antihistamine properties. Tofenacin is also the major active metabolite of orphenadrine and likely plays a role in its beneficial effects against depressive symptoms seen in Parkinson's disease patients. |
T7073
|
|
|
|
Milnacipran 是5-羟色胺-去甲肾上腺素重吸收抑制剂(SNRI),临床上可用于纤维肌痛治疗。Milnacipran 口服后吸收良好,生物利用度为 85%。 |
T70487
|
|
|
|
Tofenacin (free base) is an antidepressant drug with a tricyclic-like structure. It acts as a serotonin-norepinephrine reuptake inhibitor, and based on its close relation to orphenadrine, may also possess anticholinergic and antihistamine properties. Tofenacin is also the major active metabolite of orphenadrine and likely plays a role in its beneficial effects against depressive symptoms seen in Parkinson's disease patients. |
T60607
|
|
|
|
Dasotraline 是一种三重再摄取抑制剂,可阻断多巴胺 (DA),去甲肾上腺素 (NE) 和血清素5-羟色胺 (5-HT) 转运蛋白,IC50值分别为 4, 6 和 11 nM。Dasotraline 代表了一类潜在的新型抗抑郁药。 |
T35920
|
|
|
|
N-methyl Paroxetine is a derivative of the selective serotonin reuptake inhibitor (SSRI) antidepressant paroxetine that inhibits [3H]paroxetine binding to rat cortical membranes (Ki = 4.3 nM). It inhibits serotonin uptake in rat brain synaptosomes with an IC50 value of 22 nM. N-methyl Paroxetine has been used as a precursor in the synthesis of paroxetine and is a potential impurity in commercial preparations of paroxetine. |
T31454
|
|
|
|
Difenamizole is a nonsteroidal anti-inflammatory drug (NSAID), which is a pyrazolinone analgesic drug-related to Analgin. It has monoaminergic properties, including inhibition of monoamine oxidase, an increase of pargyline-induced striatal dopamine levels |
T73977
|
|
|
|
(S)-Dehydro Venlafaxine 是 Dehydro Venlafaxine 的非活性 S-对映异构体。Dehydro Venlafaxine 是 Venlafaxine 的杂质。Venlafaxine (Wy 45030) 是有效的 5-羟色胺 (5-HT) / 去甲肾上腺素 (NE) 再摄取双重抑制剂。 |
T1580
|
|
|
5-HT Receptor
Serotonin Transporter
Norepinephrine
|
Desvenlafaxine (O-Desmethylvenlafaxine) 是 Venlafaxine 主要代谢物的丁二酸盐形式,在人多巴胺转运体上显示弱的结合亲和力。它是一种具有口服活性的、能透过血脑屏障的5-HT 和去甲肾上腺素再摄取的抑制剂,对 hSERT 和 hNET 的IC50值分别为 47.3 nM 和 531.3 nM。 |
T61008
|
|
|
|
(±)-Duloxetine ((Rac)-Duloxetine) hydrochloride 是 Duloxetine hydrochloride 的外消旋物。Duloxetine hydrochloride 可用于研究糖尿病性神经性疼痛、纤维肌痛和重度抑郁症,它是 5-羟色胺去甲肾上腺素再摄取的抑制剂。 |
T0059
|
|
|
Histamine Receptor
|
Diphenylpyraline hydrochloride (4-Diphenylmethoxy-1-methylpiperidine hydrochloride) 是一种组胺 H1 受体的拮抗剂,抑制多巴胺的吸收。它是可口服的抗组胺试剂,具有抗胆碱和抗过敏作用,可用于缓解过敏性疾病,如鼻炎、花粉热和瘙痒性皮肤疾病等。 |