目录号 | 产品详情 | 靶点 | |
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TN2030 | 5-HT Receptor | ||
p-Hydroxyphenethyl trans-ferulate 具有抗高血糖 (酵母α-葡萄糖苷酶,IC5019.24 ± 1.73 µmol L-1),抗氧化,抗炎活性,也具有抗癌特性和血清素能特性。 | |||
T6798 | DNA Alkylator/Crosslinker DNA Alkylation | ||
Tretazicar (NSC-115829) 是一种抗肿瘤前药,由 NAD(P)H 醌氧化还原酶 2 激活。它在酶促活化后生成细胞毒性双功能烷基剂,可以形成 DNA-DNA 链间交联。 | |||
TN2272 | Nrf2 | ||
Tigloylgomisin H 是分离自S. chinensis 果实中的木酚素。Tigloylgomisin H 能诱导小鼠肝癌细胞 Hepa1c1c7 中醌还原酶活性。Tigloylgomisin H 是单功能诱导剂,通过 Nrf2-ARE 途径特异性上调 II 期解毒酶 NQO1。Tigloylgomisin H 是潜在的肝癌预防剂。 | |||
T77615 | Mitochondrial Metabolism Antibacterial | ||
ND-011992 是一种靶向醌还原酶 (quinone reductases) 和醌氧化酶 (quinol oxidases)的喹唑啉类抑制剂,具有可逆性和选择性。ND-011992 对大肠杆菌 BL21*Δcyo 呼吸复合体I (respiratory complex I) 、 bo3 氧化酶(bo3 oxidase)、 bd-I 氧化酶 (bd-I oxidases) 和 bd-II 氧化酶 (bd-II oxidases)具有抑制作用,IC50 分别为 0.12、2.47、0.63 和 1.3 μM。ND-011992 可以用于研究肺结核。 | |||
T4880 | Others Endogenous Metabolite | ||
L-Dihydroorotic acid 是一种能够通过二氢乳清酶,能够逆水解产生的无环 L-脲基琥珀酸。 | |||
T0153 | HIF/HIF Prolyl-Hydroxylase HIV Protease Reverse Transcriptase Nrf2 HIF | ||
Oltipraz (RP 35972) 是一种 Nrf2的强效激活剂。它时间依赖性地抑制 HIF-1α激活,IC50为 10 μM,浓度 ≥ 10 μM 时完全消除 HIF-1α诱导。 | |||
T32673 | |||
Leucottetraoxy MID is a quinone. | |||
T25578 | |||
Kigelinone is a quinone used as an antibacterial and antifungal. | |||
T69208 | |||
Casimiroin is a quinone reductase 2 inhibitor; isolated from Casimiroa edulis. | |||
T32140 | |||
Iguesterinn is a novel quinone triterpenoid from Catha Cassinoides with strong cell inhibitory activity. |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPH-01225 | DHODH Protein, Human, Recombinant (His) | Human | E. coli | ||
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
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TMPY-03407 | NQO1 Protein, Human, Recombinant (His) | Human | E. coli | ||
NQO1 gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. NQO1 forms homodimers and reduces quinones to hydroquinones. NQO1's enzymatic activity prevents the one-electron reduction of quinones that results in the production of radical species. Mutations in the NQO1 gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of NQO1 has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Recent pharmacological research suggests the feasibility of genotype-directed redox chemotherapeutic intervention targeting NQO1 breast cancer, a common missense genotype encoding a functionally impaired NQO1 protein.
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TMPH-02850 | DHODH Protein, Mouse, Recombinant (His) | Mouse | E. coli | ||
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
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TMPH-02627 | DHODH Protein, Mouse, Recombinant (E. coli, His) | Mouse | E. coli | ||
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
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TMPH-03278 | DHODH Protein, Rat, Recombinant (His) | Rat | E. coli | ||
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
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TMPH-00098 | AtAER Protein, Arabidopsis thaliana, Recombinant | Arabidopsis thaliana | E. coli | ||
AtAER Protein, Arabidopsis thaliana, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 38.1 kDa and the accession number is Q39172.
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TMPH-00097 | AtAER Protein, Arabidopsis thaliana, Recombinant (His & SUMO) | Arabidopsis thaliana | E. coli | ||
AtAER Protein, Arabidopsis thaliana, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 54.1 kDa and the accession number is Q39172.
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TMPH-02269 | Tyrosinase/TYR Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) | ||
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.
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TMPH-02270 | Tyrosinase/TYR Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.
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TMPH-02882 | NQO2 Protein, Mouse, Recombinant (His) | Mouse | P. pastoris (Yeast) | ||
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.
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TMPH-02797 | NQO1 Protein, Mouse, Recombinant (His) | Mouse | P. pastoris (Yeast) | ||
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinons involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. NQO1 Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 32.8 kDa and the accession number is Q64669.
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