目录号 | 产品详情 | 靶点 | |
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T22714 | Others | ||
Decynium 22 是有机阳离子转运蛋白和单胺转运蛋白的抑制剂,具有抗抑郁作用。 | |||
T9558 | transporter | ||
KL-11743 是葡萄糖竞争性 I 类葡萄糖转运蛋白抑制剂,口服有活性,能够抑制GLUT1 (IC50:115 nM) 、GLUT2 (IC50:137 nM) 、GLUT3 (IC50:90 nM) 及GLUT4 (IC50:68 nM) 。它能够特异性阻断葡萄糖代谢,也可与电子传递抑制剂协同作用诱导细胞死亡。 | |||
T3713 | transporter | ||
BAY-876 是口服有效的,选择性的葡萄糖转运蛋白 1 (GLUT1) 抑制剂(IC50= 2 nM)。BAY-876 对 GLUT1 选择性比 GLUT2,GLUT3 和 GLUT4 高(>130 倍)。BAY-876 对糖酵解代谢和卵巢癌生长也有有效的抑制作用。 | |||
T7147 | Monoamine Transporter | ||
Valbenazine (NBI-98854) 是一种高度选择性的囊泡单胺转运蛋白 2 (VMAT2) 抑制剂,Ki 为 110-190 nM,用于治疗迟发性运动障碍。 | |||
T23070 | Sodium Channel Monoamine Transporter Norepinephrine | ||
Nisoxetine hydrochloride 是一种去甲肾上腺素转运蛋白 (NET) 抑制剂,Kd 值为 0.76 nM。它是抗抑郁药和局部麻药,可以阻断电压门控性钠通道。 | |||
T9347 | transporter | ||
EAAT2 activator 1 (3-[(2-Chloro-6-fluorobenzyl)thio]-6-pyridin-2-ylpyridazine) 是兴奋性氨基酸转运蛋白 2(EAAT2) 的有效激活剂,以剂量依赖性方式增加 EAAT2 蛋白水平。 | |||
T11087 | Dopamine Receptor Serotonin Transporter Norepinephrine | ||
DOV-216,303 Free Base (DOV-216303) 是血清素、去甲肾上腺素和多巴胺再摄取的抑制剂,IC50 为 14、20 和 78 nM。 DOV-216,303 Free Base 具有抗抑郁作用。 | |||
T39429 | Dopamine Receptor | ||
AHN 1-055 hydrochloride (3α-Bis-(4-fluorophenyl) Methoxytropane hydrochloride) 与多巴胺转运蛋白具有高亲和力,是多巴胺摄取抑制剂,IC50为 71 nM。 | |||
T15160 | OAT | ||
Dotinurad ((3,5-dichloro-4-hydroxyphenyl)(1,1-dioxidobenzo[d]thiazol-3(2H)-yl)methanone) 是有效的尿酸盐重吸收选择性抑制剂,抑制尿酸盐转运蛋白 1的IC50为 37.2 nM,具有促尿酸排泄的作用。 | |||
TN6552 | Dopamine Receptor | ||
5,7-Dimethoxyluteolin 是 5,7-二甲基木犀草素的一种衍生物,可以活化多巴胺转运蛋白,EC50为 3.417 μM。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-02830 | FCGRT & B2M Heterodimer Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 | ||
FCGRT & B2M Heterodimer Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 43.5 kDa. Accession number: Q8SPV9&Q8SPW0
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TMPY-02829 | FCGRT & B2M Heterodimer Protein, Rat, Recombinant (His) | Rat | HEK293 | ||
FCGRT & B2M Heterodimer Protein, Rat, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 44 kDa. Accession number: P13599&P07151
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TMPY-05650 | FCGRT & B2M Heterodimer Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated | Cynomolgus | HEK293 | ||
FCGRT & B2M Heterodimer Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated is expressed in HEK293 cells.
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TMPY-02811 | FCGRT & B2M Heterodimer Protein, Mouse, Recombinant (His) | Mouse | HEK293 | ||
FCGRT & B2M Heterodimer Protein, Mouse, Recombinant (His) is expressed in HEK293 with His tag. The predicted molecular weight is 43.5 kDa. Accession number: Q61559&P01887
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TMPY-05539 | FCGRT & B2M Heterodimer Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 | ||
FCGRT & B2M Heterodimer Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 cells.
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TMPY-02082 | FCGRT & B2M Heterodimer Protein, Human, Recombinant (His) | Human | HEK293 | ||
FCGRT & B2M Heterodimer Protein, Human, Recombinant (His) is expressed in HEK293 cells.
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TMPY-01938 | CD98 Protein, Human, Recombinant (His) | Human | HEK293 | ||
4F2 cell-surface antigen heavy chain, also known as 4F2 heavy chain antigen, Lymphocyte activation antigen 4F2 large subunit, CD98, SLC3A2 and MDU1, is a single-pass type I I membrane protein that belongs to the SLC3A transporter family. SLC3A2 / MDU1 is expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. During gestation, expression in the placenta is significantly stronger at full-term than at the mid-trimester stage. SLC3A2 / MDU1 is expressed in HUVECS and at low levels in resting peripheral blood T-lymphocytes and quiescent fibroblasts. It is expressed in fetal liver and in the astrocytic process of primary astrocytic gliomas. SLC3A2 / MDU1 is also expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco2-BBE. SLC3A2 / MDU1 is required for the function of light chain amino-acid transporters. It is involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. SLC3A2 / MDU1 is involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7, SLC3A2 / MDU1 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. SLC3A2 / MDU1 plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. It is required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, SLC3A2 / MDU1 is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta.
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TMPY-02358 | CD98 Protein, Mouse, Recombinant (His) | Mouse | HEK293 | ||
4F2 cell-surface antigen heavy chain, also known as 4F2 heavy chain antigen, Lymphocyte activation antigen 4F2 large subunit, CD98, SLC3A2 and MDU1, is a single-pass type I I membrane protein that belongs to the SLC3A transporter family. SLC3A2 / MDU1 is expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. During gestation, expression in the placenta is significantly stronger at full-term than at the mid-trimester stage. SLC3A2 / MDU1 is expressed in HUVECS and at low levels in resting peripheral blood T-lymphocytes and quiescent fibroblasts. It is expressed in fetal liver and in the astrocytic process of primary astrocytic gliomas. SLC3A2 / MDU1 is also expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco2-BBE. SLC3A2 / MDU1 is required for the function of light chain amino-acid transporters. It is involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. SLC3A2 / MDU1 is involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7, SLC3A2 / MDU1 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. SLC3A2 / MDU1 plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. It is required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, SLC3A2 / MDU1 is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta.
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TMPY-05148 | FCGRT & B2M Heterodimer Protein, Rat, Recombinant (His), Biotinylated | Rat | HEK293 | ||
FCGRT & B2M Heterodimer Protein, Rat, Recombinant (His), Biotinylated is expressed in HEK293 with His tag. The predicted molecular weight is 44 kDa. Accession number: P13599&P07151
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TMPY-02209 | CUTC Protein, Human, Recombinant (His) | Human | E. coli | ||
Copper homeostasis protein cutC homolog, also known as CGI-32 and CUTC, is a cytoplasm and nucleus protein which belongs to theCutC family. CUTC may play a role in copper homeostasis. It can bind one Cu1+per subunit. Copper is an essential trace element to life and particularly plays a pivotal role in the physiology of aerobic organisms. Copper is a micronutrient that is required for proper metabolic functioning of most prokaryotic and eukaryotic organisms. To sustain an adequate supply of copper, a cell requires molecular mechanisms that control the metal content to avoid copper toxicity. This toxicity comes primarily from the reactivity of copper, which can lead to the generation of free radicals. In bacteria, two independent systems are responsible for maintaining the balance of copper within the cells ( Cop and Cut family proteins ). The Cut protein family is associated with copper homeostasis and involved in uptake, storage, delivery, and efflux of copper. CutC is a member of the Cut family and is suggested to be involved in efflux trafficking of cuprous ion. CutC is able to respond transcriptionally to copper and to participate in the control of copper homeostasis in E. faecalis.
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TMPY-05149 | FCGRT & B2M Heterodimer Protein, Cynomolgus, Recombinant (His), Biotinylated | Cynomolgus | HEK293 | ||
FCGRT & B2M Heterodimer Protein, Cynomolgus, Recombinant (His), Biotinylated is expressed in HEK293 with His tag. The predicted molecular weight is 43.5 kDa. Accession number: Q8SPV9&Q8SPW0
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TMPY-05147 | FCGRT & B2M Heterodimer Protein, Mouse, Recombinant (His), Biotinylated | Mouse | HEK293 | ||
FCGRT & B2M Heterodimer Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 with His tag. The predicted molecular weight is 44.2 kDa. Accession number: Q61559&P01887
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TMPY-05649 | FCGRT & B2M Heterodimer Protein, Mouse, Recombinant (His & Avi), Biotinylated | Mouse | HEK293 | ||
FCGRT & B2M Heterodimer Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 with His and AVI tag. The predicted molecular weight is 46 kDa. Accession number: Q61559
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TMPY-03857 | MMGT1 Protein, Human, Recombinant (His) | Human | HEK293 | ||
MMGT1 (Membrane Magnesium Transporter 1, also known as EMC5 and TMEM32) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. The encoded protein belongs to the membrane magnesium transporter (TC 1.A.67) family which is a group of magnesium transporters that are part of the TOG superfamily. It mediates Mg(2+) transport. MMGT1 is described as having 335 amino acids and five TMSs with an N-terminal cleavage site and some phosphorylation sites. It is widely expressed in the thyroid, bone marrow, and other tissues. Diseases associated with MMGT1 include Cercarial Dermatitis. Among its related pathways are the Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds, and Miscellaneous transport and binding events.
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TMPY-05448 | FCGRT & B2M Heterodimer Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 | ||
FCGRT & B2M Heterodimer Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 with His and AVI tag. The predicted molecular weight is 45.3 kDa. Accession number: NP_004098.1&NP_004039.1
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TMPY-05036 | FCGRT & B2M Heterodimer Protein, Human, Recombinant (His & Avi) | Human | HEK293 | ||
FCGRT & B2M Heterodimer Protein, Human, Recombinant (His & Avi) is expressed in HEK293 with His and AVI tag. The predicted molecular weight is 45.3 kDa. Accession number: NP_004098.1&NP_004039.1
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TMPY-04631 | CD98 Protein, Rat, Recombinant (hFc) | Rat | HEK293 | ||
4F2 cell-surface antigen heavy chain, also known as 4F2 heavy chain antigen, Lymphocyte activation antigen 4F2 large subunit, CD98, SLC3A2 and MDU1, is a single-pass type I I membrane protein that belongs to the SLC3A transporter family. SLC3A2 / MDU1 is expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. During gestation, expression in the placenta is significantly stronger at full-term than at the mid-trimester stage. SLC3A2 / MDU1 is expressed in HUVECS and at low levels in resting peripheral blood T-lymphocytes and quiescent fibroblasts. It is expressed in fetal liver and in the astrocytic process of primary astrocytic gliomas. SLC3A2 / MDU1 is also expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco2-BBE. SLC3A2 / MDU1 is required for the function of light chain amino-acid transporters. It is involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. SLC3A2 / MDU1 is involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7, SLC3A2 / MDU1 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. SLC3A2 / MDU1 plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. It is required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, SLC3A2 / MDU1 is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta.
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TMPY-03307 | CD98 Protein, Rat, Recombinant (His) | Rat | HEK293 | ||
4F2 cell-surface antigen heavy chain, also known as 4F2 heavy chain antigen, Lymphocyte activation antigen 4F2 large subunit, CD98, SLC3A2 and MDU1, is a single-pass type I I membrane protein that belongs to the SLC3A transporter family. SLC3A2 / MDU1 is expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. During gestation, expression in the placenta is significantly stronger at full-term than at the mid-trimester stage. SLC3A2 / MDU1 is expressed in HUVECS and at low levels in resting peripheral blood T-lymphocytes and quiescent fibroblasts. It is expressed in fetal liver and in the astrocytic process of primary astrocytic gliomas. SLC3A2 / MDU1 is also expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco2-BBE. SLC3A2 / MDU1 is required for the function of light chain amino-acid transporters. It is involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. SLC3A2 / MDU1 is involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7, SLC3A2 / MDU1 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. SLC3A2 / MDU1 plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. It is required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, SLC3A2 / MDU1 is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta.
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TMPH-01711 | ABCC1 Protein, Human, Recombinant (His) | Human | E. coli | ||
Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export. Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation. Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells.
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TMPY-01118 | SLC27A4/FATP4 Protein, Human, Recombinant (His) | Human | HEK293 | ||
SLC27A4/ATG4B complex might act as a new potential therapeutic target of lung tumor chemotherapy. The solute carrier 27A (SLC27A) gene family encodes fatty acid transport proteins (FATPs) and includes 6 members. Autism spectrum disorders (ASD) are now recognized as disorders caused by impaired early brain development, it is possible that functional abnormalities of SLC27A genes may contribute to the pathogenesis of ASD. The expression of SLC27A3 and SLC27A4 in human neural stem cells derived from human induced pluripotent stem cells, which suggested their involvement in the developmental stage of the central nervous system.
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TMPJ-00583 | CDH17 Protein, Human, Recombinant (His) | Human | Human Cells | ||
Cadherin-17 is a single-pass type I membrane protein that belongs to the cadherin superfamily. Cadherin-17 consists of one extracellular region containing seven cadherin domains and one transmembrane region but it lacks the conserved cytoplasmic domain. Cadherin-17 is expressed in the gastrointestinal tract and pancreatic duct. Cadherins are calcium dependent cell adhesion proteins and preferentially interact with each other in a homophilic manner in connecting cells. Cadherin-17 may have a role in the morphological organization of liver and intestine and involved in intestinal peptide transport.
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TMPY-06611 | CD98 Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 | ||
4F2 cell-surface antigen heavy chain, also known as 4F2 heavy chain antigen, Lymphocyte activation antigen 4F2 large subunit, CD98, SLC3A2 and MDU1, is a single-pass type I I membrane protein that belongs to the SLC3A transporter family. SLC3A2 / MDU1 is expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. During gestation, expression in the placenta is significantly stronger at full-term than at the mid-trimester stage. SLC3A2 / MDU1 is expressed in HUVECS and at low levels in resting peripheral blood T-lymphocytes and quiescent fibroblasts. It is expressed in fetal liver and in the astrocytic process of primary astrocytic gliomas. SLC3A2 / MDU1 is also expressed in retinal endothelial cells and in the intestinal epithelial cell line Caco2-BBE. SLC3A2 / MDU1 is required for the function of light chain amino-acid transporters. It is involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. SLC3A2 / MDU1 is involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7, SLC3A2 / MDU1 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. SLC3A2 / MDU1 plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. It is required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, SLC3A2 / MDU1 is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta.
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TMPH-00981 | ABCB1 Protein, Human, Recombinant (His) | Human | E. coli | ||
ABCB1 Protein, Human, Recombinant (His) is expressed in E. coli.
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TMPH-00206 | Pertactin autotransporter Protein, Bordetella pertussis, Recombinant (His & SUMO) | Bordetella pertussis | E. coli | ||
Agglutinogen that binds to eukaryotic cells; a process mediated by the R-G-D sequence. Pertactin may have a role in bacterial adhesion, and thus play a role in virulence. May contribute to the disease state of whooping cough.
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TMPY-03120 | Prostaglandin D2 Synthase Protein, Human, Recombinant (His) | Human | HEK293 | ||
PTGDS, also known as L-PGDS, belongs to the calycin superfamily, lipocalin family. Lipocalins share limited regions of sequence homology and a common tertiary structure architecture. They transport small hydrophobic molecules such as steroids, bilins, retinoids, and lipids. PTGDS is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of PGH2 to PGD2. It is involved in smooth muscle contraction/relaxation and a variety of central nervous system functions. PTGDS may have an anti-apoptotic role in oligodendrocytes. It binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system.
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TMPY-05047 | CD44 Protein, Mouse, Recombinant (His) | Mouse | HEK293 | ||
CD44 is a type I transmembrane protein and a member of the cartilage link protein family. It is involved in cell-cell and cell-matrix interactions and signal transduction. Several CD44 ligands have been identified. The most extensively characterized ligand for CD44 is hyaluronan, a component of the extracellular matrix. CD44 protein is expressed on the majority of immune cells. The binding of CD44 to hyaluronan is induced on T lymphocytes after activation by antigen and on monocytes after stimulation by inflammatory agents. Under inflammatory conditions, CD44 on endothelial cells presents hyaluronan to CD44 on activated T lymphocytes and mediates a rolling interaction under flow conditions. Perturbations of the hyaluronan-CD44 interaction at the plasma membrane by various antagonists result in attenuation of receptor tyrosine kinase and transporter activities and inhibition of tumor progression in vivo. CD44 is known to interact with the ezrin family (ERM family) members and form a complex that plays diverse roles within both normal and abnormal cells, particularly cancer cells. CD44 and ezrin and their respective complex have properties suggesting that they may be important in the process of tumour-endothelium interactions, cell migrations, cell adhesion, tumour progression and metastasis.
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TMPY-02033 | CD44 Protein, Human, Recombinant (His) | Human | HEK293 | ||
CD44 is a type I transmembrane protein and a member of the cartilage link protein family. It is involved in cell-cell and cell-matrix interactions and signal transduction. Several CD44 ligands have been identified. The most extensively characterized ligand for CD44 is hyaluronan, a component of the extracellular matrix. CD44 protein is expressed on the majority of immune cells. The binding of CD44 to hyaluronan is induced on T lymphocytes after activation by antigen and on monocytes after stimulation by inflammatory agents. Under inflammatory conditions, CD44 on endothelial cells presents hyaluronan to CD44 on activated T lymphocytes and mediates a rolling interaction under flow conditions. Perturbations of the hyaluronan-CD44 interaction at the plasma membrane by various antagonists result in attenuation of receptor tyrosine kinase and transporter activities and inhibition of tumor progression in vivo. CD44 is known to interact with the ezrin family (ERM family) members and form a complex that plays diverse roles within both normal and abnormal cells, particularly cancer cells. CD44 and ezrin and their respective complex have properties suggesting that they may be important in the process of tumour-endothelium interactions, cell migrations, cell adhesion, tumour progression and metastasis.
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TMPY-01146 | Insulin Receptor Protein, Human, Recombinant (long isoform, His) | Human | HEK293 | ||
INSR (Insulin receptor), also known as CD22, is a transmembrane receptor that is activated by insulin. INSR belongs to the protein kinase superfamily and exists as a tetramer consisting of two alpha subunits and two beta subunits linked by disulfide bonds. The alpha and beta subunits are encoded by a single INSR gene, and the beta subunits pass through the cellular membrane. As the receptor for insulin with tyrosine-protein kinase activity, INSR associates with downstream mediators upon binding to insulin, including IRS1 (insulin receptor substrate 1) and phosphatidylinositol 3'-kinase (PI3K). IRS-1 binding and phosphorylation eventually lead to an increase in the high-affinity glucose transporter (Glut4) molecules on the outer membrane of insulin-responsive tissues. INSR isoform long and isoform short are expressed in the peripheral nerve, kidney, liver, striated muscle, fibroblasts and skin, and is found as a hybrid receptor with IGF1R which also binds IGF1 in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen, and placenta. Defects in Insulin Receptor/INSR are the cause of Rabson-Mendenhall syndrome (Mendenhall syndrome), insulin resistance (Ins resistance), leprechaunism (Donohue syndrome), and familial hyperinsulinemic hypoglycemia 5 (HHF5). It may also be associated with noninsulin-dependent diabetes mellitus (NIDDM).
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TMPY-01912 | Cadherin 17/CDH17 Protein, Human, Recombinant (His) | Human | HEK293 | ||
Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular region, 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing of the encoding gene results in multiple transcript variants. Cadherin-17/LI-cadherin preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin-17 may thus contribute to the sorting of heterogeneous cell types and have a role in the morphological organization of liver and intestine. It's also involved in intestinal peptide transport. Experiments have reported the association between Cadherin-17/LI-cadherin and gastric cancer. Cadherin-17/LI-cadherin expression was detected in 63/94 of gastric adenocarcinomas in addition to intestinal metaplasia. The expression of Cadherin-17 tended to be associated with intestinal type carcinoma, and carcinomas with Cadherin-17 expression was significantly more frequent in advanced stage cases than in early stage. Cadherin-17 is also a useful immunohistochemical marker for diagnosis of adenocarcinomas of the digestive system.
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TMPY-02919 | Cadherin 17/CDH17 Protein, Rat, Recombinant (His) | Rat | HEK293 | ||
Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular region, 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing of the encoding gene results in multiple transcript variants. Cadherin-17/LI-cadherin preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin-17 may thus contribute to the sorting of heterogeneous cell types and have a role in the morphological organization of liver and intestine. It's also involved in intestinal peptide transport. Experiments have reported the association between Cadherin-17/LI-cadherin and gastric cancer. Cadherin-17/LI-cadherin expression was detected in 63/94 of gastric adenocarcinomas in addition to intestinal metaplasia. The expression of Cadherin-17 tended to be associated with intestinal type carcinoma, and carcinomas with Cadherin-17 expression was significantly more frequent in advanced stage cases than in early stage. Cadherin-17 is also a useful immunohistochemical marker for diagnosis of adenocarcinomas of the digestive system.
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TMPY-05352 | Cadherin 17/CDH17 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 | ||
Cadherin-17 or LI-cadherin is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Cadherin-17/LI-cadherin is a cadherin-like protein consisting of an extracellular region, 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine. Alternative splicing of the encoding gene results in multiple transcript variants. Cadherin-17/LI-cadherin preferentially interact with themselves in a homophilic manner in connecting cells. Cadherin-17 may thus contribute to the sorting of heterogeneous cell types and have a role in the morphological organization of liver and intestine. It's also involved in intestinal peptide transport. Experiments have reported the association between Cadherin-17/LI-cadherin and gastric cancer. Cadherin-17/LI-cadherin expression was detected in 63/94 of gastric adenocarcinomas in addition to intestinal metaplasia. The expression of Cadherin-17 tended to be associated with intestinal type carcinoma, and carcinomas with Cadherin-17 expression was significantly more frequent in advanced stage cases than in early stage. Cadherin-17 is also a useful immunohistochemical marker for diagnosis of adenocarcinomas of the digestive system.
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TMPH-02324 | SLC39A6 Protein, Human, Recombinant (His) | Human | Baculovirus | ||
May act as a zinc-influx transporter.
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TMPH-03414 | RT0041 Protein, Rickettsia typhi, Recombinant (His & Myc) | Rickettsia typhi | E. coli | ||
Could be part of an ABC transporter complex.
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TMPH-02333 | SLC25A19 Protein, Human, Recombinant (His) | Human | in vitro E. coli expression system | ||
Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria.
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TMPH-03591 | PsaA Protein, S. pneumoniae, Recombinant (His & Myc) | Streptococcus pneumoniae | E. coli | ||
Part of an ABC transporter complex involved in manganese import.
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TMPH-00628 | GltI/YbeJ Protein, E. coli, Recombinant (His & SUMO) | E. coli | E. coli | ||
Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Binds to both glutamate and aspartate.
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TMPH-00652 | MMBP Protein, E. coli, Recombinant (His & Myc) | E. coli | E. coli | ||
Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins such as maltotriose.
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TMPH-02123 | SLC2A9 Protein, Human, Recombinant (His) | Human | in vitro E. coli expression system | ||
Urate transporter, which may play a role in the urate reabsorption by proximal tubules. Does not transport glucose, fructose or galactose.
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TMPH-02323 | SLC30A8 Protein, Human, Recombinant (His) | Human | in vitro E. coli expression system | ||
Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells.
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TMPH-00786 | BtuD Protein, Halobacterium salinarum, Recombinant (His) | Halobacterium salinarum | E. coli | ||
Required for corrinoid utilization. Probably part of the ABC transporter complex BtuCDF involved in cobalamin (vitamin B12) import. Probably responsible for energy coupling to the transport system.
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TMPH-02177 | Tapasin Protein, Human, Recombinant (His & Myc) | Human | E. coli | ||
Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading).
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TMPH-00787 | BtuD Protein, Halobacterium salinarum, Recombinant | Halobacterium salinarum | E. coli | ||
Required for corrinoid utilization. Probably part of the ABC transporter complex BtuCDF involved in cobalamin (vitamin B12) import. Probably responsible for energy coupling to the transport system.
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TMPH-02554 | BCAT2 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli | ||
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids.
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TMPH-02979 | SLC30A8 Protein, Mouse, Recombinant (His) | Mouse | in vitro E. coli expression system | ||
Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells.
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TMPH-01390 | G6PC Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.
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TMPH-01696 | SLC16A4 Protein, Human, Recombinant (His) | Human | E. coli | ||
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.
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TMPH-03561 | lsdB Protein, S. aureus, Recombinant (His & SUMO) | Staphylococcus aureus | E. coli | ||
Cell wall-anchored surface receptor that extracts heme from oxidized metHb to enable growth on hemoglobin as a sole iron source. Rapidly extracts heme from hemoglobin and transfers it to IsdA or IsdC, which then relays it to the membrane transporter/IsdEF for internalization. Promotes also resistance to hydrogen peroxide and killing by neutrophils.
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TMPH-01389 | G6PC Protein, Human, Recombinant (His) | Human | Yeast | ||
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels.
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TMPJ-00533 | LYVE1 Protein, Human, Recombinant (His) | Human | Human Cells | ||
Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1 is a single-pass type I membrane protein. LYVE-1 is a CD44 homolog found primarily on lymphatic endothelial cells 1. LYVE-1 mainly expressed in endothelial cells lining lymphatic vessels. While LYVE-1 functions is a Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. LYVE-1 plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). It may act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
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TMPH-02119 | SLC5A2 Protein, Human, Recombinant (His & Myc) | Human | E. coli | ||
Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1.; Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.
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