目录号 | 产品详情 | 靶点 | |
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T9592 | Others | ||
OATD-01 是一种壳三糖苷酶及酸性哺乳动物几丁质酶的高活性抑制剂,对CHIT1具有低纳摩尔活性 (hCHIT1,IC50=23 nM)。它在多个物种中显示出良好的药代动力学特征,在体内具有显著的抗纤维化活性,可用于研究肺纤维化。 | |||
T36605 | |||
Isoprostanes are prostaglandin (PG)-like products of free-radical induced lipid peroxidation. Although the isoprostanes derived from arachidonic acid are the best characterized, many other polyunsaturated fatty acids can form isoprostanes. (±)5-iPF2α-VI is one of dozens of possible stereo- and regioisomeric isoprostanes which can be formed from arachidonic acid. To date, the most extensively studied of these is 8-isoprostane (8-epi-PGF2α, iPF2α-III). However, 8-isoprostane is a minor isoprostane constituent when compared to some of the other isomers which form in natural conditions of oxidative stress. (±)5-iPF2α-VI is an isoprostane from the unique Type VI class of isoprostanes. This class has been shown to be one of the major isoprostane products, in contrast to 8-isoprostane. In addition to being produced in greater abundance than 8-isoprostane, Type VI isoprostanes form internal lactones, which facilitates their extraction and purification from biological samples. | |||
T9688 | JNK | ||
CC-90001 是口服有效的 c-Jun N 末端激酶选择性抑制剂。在基于细胞的模型中,CC-90001显示出对JNK1的选择性是JNK2的 12.9 倍。CC-90001在特发性肺纤维化方面有研究价值。 | |||
T4016 | LPA Receptor LPL Receptor | ||
BMS-986020 (AM152) 是一种高亲和力溶血磷脂酸受体 1 拮抗剂,有用于特发性肺纤维化的研究潜力。它抑制胆汁酸和磷脂转运蛋白,抑制 BSEP、MRP4 和 MDR3,IC50值分别为 4.8、6.2 和 7.5 μM。 | |||
T75004 | Others | ||
TGFβ1-IN-2,一种二芳基酰基腙衍生物,有效抑制成纤维细胞活化与增殖,常用于特发性肺纤维化(IPF)研究。 | |||
T75005 | Others | ||
TGFβ1-IN-3 是一种二芳基酰基腙衍生物,对成纤维细胞的活化和增殖有抑制作用。TGFβ1-IN-3 是治疗特发性肺纤维化 (IPF) 的候选化合物。 | |||
T76856 | MMP Virus Protease | ||
Andecaliximab 是一种靶向基质金属蛋白酶 9 (MMP9) 的重组 IgG4 单克隆抗体。Andecaliximab 在特发性肺纤维化小鼠模型中显示出抗纤维化作用。Andecaliximab 可用于研究胃腺癌和特发性肺纤维化 (IPF) 以及登革热病毒。 | |||
T3795 | Apoptosis TLR Reverse Transcriptase Antibacterial Autophagy | ||
Corilagin 是一种鞣酸,有抑制 RNA 肿瘤病毒逆转录酶的活性。它抑制金黄色葡萄球菌的生长,MIC 为 25 μg/mL。它有抗肿瘤活性,可用于肝癌和卵巢癌。 | |||
T73035 | |||
STAT3-IN-15是一款有效、具口服活性的STAT3抑制剂,用于对抗特发性肺纤维化(IPF)。该化合物阻止STAT3磷酸化,同时抑制TGF-β1引起的上皮细胞迁移及变形,并防止上皮间质转化(EMT)。 | |||
T76804 | |||
FG-3019 (Pamrevlumab)为重组人源化抗体,特异性结合于结缔组织生长因子(CTGF)。适用于特发性肺纤维化(IPF)研究领域。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-00371 | STC1 Protein, Human, Recombinant (His) | Human | HEK293 | ||
Stanniocalcin-1 (STC1) is a paracrine factor associated with inflammation and carcinogenesis. STC1 is a secreted glycoprotein hormone and involved in various types of human malignancies. Stanniocalcin-1 (STC1), which has myriad functions, including the maintenance of calcium homeostasis, the promotion of early wound healing, uncoupling respiration (aerobic glycolysis), reepithelialization in damaged tissues, the inhibition of vascular leakage, and the regulation of macrophage functions to keep epithelial and endothelial homeostasis, which may adequately cover the myriad therapeutic targets of IPF. STC1 signals through inhibitory G-protein modulates CGRP receptor spatial localization during osteoblastogenesis and may function as a regulatory factor interacting with calcitonin peptide members during bone formation.
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