目录号 | 产品详情 | 靶点 | |
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T4644 | AhR Aryl Hydrocarbon Receptor | ||
Tapinarof (Benvitimod) 是一种从发光杆菌中提取的天然产物,可消除炎症。它是芳烃受体 (AhR) 激动剂,EC50为 13 nM。 | |||
T20625 | Estrogen Receptor/ERR AhR Androgen Receptor Antifungal | ||
Prochloraz (Prelude) 是咪唑类抗真菌剂。Prochloraz 抑制羊毛甾醇的细胞色素 P450 依赖性 14α-脱甲基作用,由此抑制麦角固醇的生物合成,从而导致真菌细胞膜破裂和细胞死亡。它也是雌激素受体和 雄激素受体的拮抗剂,IC50分别为25 μM 和4 μM, 并激活芳烃受体,EC50为1μM。 | |||
T69174 | |||
AHR-5645B free base is a substituted benzamide which has been shown to inhibit 3H-spiperone binding to bovine anterior pituitary membranes. | |||
TN2883 | Others PARP | ||
3',4'-Dimethoxyflavone 是类黄酮化合物的参考标准,类黄酮化合物具有多种药用活性。 | |||
T12208 | Others | ||
Nepafenac D5 is the deuterium labeled Nepafenac, which is a selective inhibitor of COX-2 . | |||
T4939 | Others | ||
Indole-3-pyruvic acid (3-(3-Indolyl)-2-oxopropanoic acid) 是一种参与Indole-3-acetic acid 生物合成的化合物,Indole-3-acetic acid 是一种植物激素,在调节生长和对环境变化的反应中起重要作用。 | |||
T0640 | Others Aryl Hydrocarbon Receptor | ||
Benzyl butyl phthalate (1,2-benzenedicarboxylic acid) 是邻苯二甲酸酯的一员,可激活乳腺癌细胞中的芳香烃受体,刺激 SPHK1/S1P/S1PR3 信号传导,促进转移性乳腺癌干细胞的形成。它通过上调 Zeb1 的表达,可引起血管瘤细胞的迁移和侵袭。 | |||
T5281 | AhR p38 MAPK Aryl Hydrocarbon Receptor Endogenous Metabolite Antibacterial Autophagy Antifungal | ||
Skatole (3-Methyl-1H-indole) 是由肠道菌群产生的,通过激活芳基烃受体和 p38调节肠上皮细胞功能。 | |||
T2947 | E1/E2/E3 Enzyme NF-κB Aryl Hydrocarbon Receptor Endogenous Metabolite p53 | ||
Indole-3-carbinol (I3C) 是樟子松中的一种天然产物,是可口服的硫代葡萄糖苷葡糖苷酶裂解产物。它是芳烃受体 (AhR) 的激动剂,可抑制 NF-κB 和 IκBα 激酶活化。 | |||
T2707 | Ferroptosis Aryl Hydrocarbon Receptor p53 | ||
Pifithrin-α hydrobromide (Pifithrin-α hydrobromide) 是一种 p53 抑制剂,可抑制 p53 反应基因的 p53 依赖性反式激活。它也是芳烃受体的激动剂。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPH-00958 | AHR Protein, Human, Recombinant (His) | Human | E. coli | ||
AHR Protein, Human, Recombinant (His) is expressed in E. coli.
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TMPJ-00423 | TIM-1/KIM-1/HAVCR1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
TIM-1/KIM-1/HAVCR belongs to the immunoglobulin superfamily that cosisits 305 amino acid (aa). It is expressed by stimulated T-cells. TIM-1/KIM-1/HAVCR may play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4. And may have a role in kidney injury and repair. Belongs to the T-cell and airway phenotype regulator (Tapr) locus, a single chromosomal region that confers reduced T-helper type 2 responsiveness and protects against airway hyperactivity (AHR), the hallmark of human asthma.
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