目录号 | 产品详情 | 靶点 | |
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T62431 | |||
HIV-1 inhibitor-25 (compound R-12a) 是一种 HIV-1 逆转录 (HIV-1 RT) 的高效抑制剂 (IC50: 0.1061 nM)。HIV-1 inhibitor-25 对野生型 HIV-1 表现出较高的抗病毒效果,其 EC50 值为 13.6 nM,且细胞毒性较低 (对 MT-4 细胞的 CC50 值为 33.13 μM)。HIV-1 inhibitor-25 也能够抑制 HIV-1 突变株 (L100I, K103 N, Y181C, Y188L, E138K, F227L+V106A),EC50=0.1961 ~ 5.8136 μM。HIV-1 inhibitor-25 能够用于研究艾滋病。 | |||
T82474 | |||
Empasiprubart (ARGX-117) 是一种针对补体 C2 的人源化抑制性单克隆抗体。该抗体通过结合 C2 的 Sushi-2 结构域来阻止 C3 原转化酶的形成,进而抑制 C3 的激活,并阻断经典途径与凝集素途径的上游激活。Empasiprubart 展现出 pH 和钙依赖性的靶标结合能力,并在自身免疫性溶血性贫血以及抗体介导的器官移植排斥模型中,预防了补体介导的细胞毒性作用。 | |||
T82021 | |||
Izeltabart(IMGC-936)是一款针对ADAM9的基于Maytansinoid的ADC,由与DM21-C位点特异性偶联的高亲和力人源化抗体构成,使Maytansinoid微管破坏载体通过稳定的三肽连接子进行传递,达到药物-抗体比约为2.0。Izeltabart在ADAM9阳性人类肿瘤细胞系上显示出明显的细胞毒性,并在动物异种移植肿瘤模型中展现出显著的抗肿瘤效果。 | |||
T79567 | Influenza Virus | ||
Antiviralagent 35 (compound 4d) 作为一种口服抗流感病毒药物,针对流感病毒复制的早期阶段有效。该化合物能够阻断流感病毒引发的ROS积聚、自噬及细胞凋亡,同时在肺部感染的小鼠模型中,抑制RIG-1通路所介导的炎症响应。Antiviralagent 35展现出低细胞毒性(CC50>800 μM,MDCK细胞)且对H1N1(A/Weiss/43)展现出显著的抗病毒活性,EC50为2.28 μM。 | |||
T81968 | |||
KY-1044 (Alomfilimab; SAR 445256) 是一种全人IgG1抗体,针对诱导型共刺激受体(ICOS)。该化合物借助FcgRIIIa作用,通过抗体依赖性细胞毒性(ADCC)清除高表达ICOS的细胞,并在低表达ICOS的CD8+TEff细胞上通过FcgR依赖的聚集发挥共刺激作用。通过操纵T细胞亚型上ICOS的异质性表达,KY-1044旨在优化肿瘤微环境,并恢复对肿瘤的免疫应答。 | |||
T79221 | RSV | ||
RSVL-protein-IN-5(compound E)是一种高效针对呼吸道合胞病毒(RSV)的抑制剂,拥有EC50值为0.1 μM。该化合物在IC50为0.66 μM的条件下能够抑制聚合酶(Polymerase),并通过阻断病毒转录物的鸟苷酸化过程来抑止RSVmRNA的合成。RSVL-protein-IN-5具有中等细胞毒性(CC50为10.7 μM,HEp-2细胞),同时,在每日4.1 mg/kg剂量下,能减少RSV感染小鼠模型中的病毒滴度。 | |||
T83921 | |||
IMCTA-C14是一种洗涤剂且是微生物代谢产物4-糖腺苷的衍生物。其临界胶束浓度(CMC)为0.11 mM,亲水亲油平衡(HLB)值为9.72。IMCTA-C14(0.05%和0.5%)能从OVK18卵巢癌细胞提取蛋白质,包括膜蛋白。它对几种不同菌株具有活性(MICs = 8-128 µg/ml),并对52种癌细胞系具有细胞毒性(IC50s = 2.9-29.2 µg/ml)。IMCTA-C14(50 µM)诱导OVK18细胞的自噬。 | |||
T79065 | Epigenetic Reader Domain | ||
WWL0245是一种高效的选择性BRD4 PROTAC,能够在DC50小于1 nM的低浓度下选择性地降解BRD4,而对BRD2/3和PLK1的降解效果则在DC50大于1 μM时才显现。在BETi敏感的多种癌细胞系中,尤其是AR阳性的前列腺癌细胞系,WWL0245展现出显著的选择性细胞毒性效果。作为AR阳性前列腺癌研究的潜力药物,WWL0245也被视为研究BRD4生物学功能的重要工具化合物。 | |||
T83855 | |||
TG2-179-1是BRCA1相关蛋白1(BAP1)的抑制剂。它在25 µM至1.5 mM的浓度范围内,通过无细胞测定法抑制BAP1的去泛素化活性。TG2-179-1对八种结肠癌细胞系表现出细胞毒性(IC50s = 4.48-7.52 µM)。在体内,TG2-179-1(10和30 mg/kg)能够减少HCT116结肠癌小鼠异种移植模型中的肿瘤体积。 | |||
T71082 | |||
DW532 is one of simplified analogues of hematoxylin that has shown broad-spectrum inhibition on tyrosine kinases and in vitro anti-cancer activities. DW532 inhibited EGFR and VEGFR2 in vitro kinase activity (the IC50 values were 4.9 and 5.5 μmol/L, respectively), and suppressed their downstream signaling. DW532 dose-dependently inhibited tubulin polymerization via direct binding to tubulin, thus disrupting the mitotic spindle assembly and leading to abnormal cell division. In a panel of human cancer cells, DW532 (1 and 10 μmol/L) induced G2/M phase arrest and cell apoptosis, which subsequently resulted in cytotoxicity. Knockdown of BubR1 or Mps1, the two core proteins of the spindle assembly checkpoint dramatically decreased DW532-induced cell cycle arrest in MDA-MB-468 cells. Moreover, treatment with DW532 potently and dose-dependently suppressed angiogenesis in vitro and in vivo. ( Acta Pharmacol Sin. 2014 Jul;35(7):916-28.) |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-04616 | NKp30/NCR3 Protein, Cynomolgus, Rhesus, Recombinant (His) | Cynomolgus,Rhesus | HEK293 Cells | ||
NKp30/NCR3 Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.3 kDa and the accession number is XP_005553604.1.
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TMPY-05511 | NKp46/NCR1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
NKp46/NCR1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.6 kDa and the accession number is A0A0R4IZY7.
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TMPY-01807 | NKp44/NCR2 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
NKp44/NCR2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20 kDa and the accession number is O95944-1.
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TMPY-01145 | NKp30/NCR3 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
NKp30/NCR3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.4 kDa and the accession number is O14931-1.
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TMPY-00334 | NKp30/NCR3 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
NKp30/NCR3 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.2 kDa and the accession number is CAD23066.1.
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TMPY-03233 | NKp46/NCR1 Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
NKp46/NCR1 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.1 kDa and the accession number is Q9Z0H5.
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TMPY-04617 | B7-H6 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 Cells | ||
B7-H6 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 53.2 kDa and the accession number is XP_005578557.1.
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TMPY-04495 | B7-H6 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
B7-H6 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35.1 kDa and the accession number is XP_006223356.1.
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TMPY-04618 | B7-H6 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
B7-H6 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.9 kDa and the accession number is XP_005578557.1.
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TMPY-00327 | B7-H6 Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
B7-H6 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 60.4 kDa and the accession number is XP_006223356.1.
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TMPY-06363 | B7-H6 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated | Cynomolgus | HEK293 Cells | ||
B7-H6 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 29.76 kDa and the accession number is XP_005578557.1.
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TMPY-04619 | B7-H6 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
B7-H6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.1 kDa and the accession number is Q68D85.
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TMPY-05383 | NKp30/NCR3 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
NKp30/NCR3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39.6 kDa and the accession number is O14931-3.
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TMPY-00377 | B7-H6 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
B7-H6 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 53.4 kDa and the accession number is Q68D85.
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TMPY-06178 | B7-H6 Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 Cells | ||
B7-H6 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.1 kDa and the accession number is Q68D85.
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TMPY-05367 | NKp44/NCR2 Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 Cells | ||
NKp44/NCR2 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20 kDa and the accession number is O95944-1.
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TMPJ-00083 | NCR3 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
Natural Cytotoxicity Triggering Receptor 3 (NCR3) along with NKp44 and NKp46 constitute a group of receptors termed “Natural Cytotoxicity Receptors”. They play a major role in triggering NK-mediated killing of most tumor cells lines. NKp30 is a type I transmembrane protein having a single extracellular V-like immunoglobulin domain. NKp30 is selectively expressed both in resting and activated human NK cells. In addition, NKp30 is also involved in NK-mediated induction of dendritic cell (DC) maturation. It has been demonstrated that NK cell activation signaling specifically induces lytic activity against several tumor cell types and synthesis of new NF-κB dependent proteins during the initiation of cytotoxicity.
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TMPJ-00567 | NCR1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
Natural cytotoxicity triggering receptor 1(NCR1) is a single-pass type I membrane protein .It contains 2 Ig-like (immunoglobulin-like) domains and belongs to the natural cytotoxicity receptor (NCR) family. The protein is a natural killer (NK) lymphocyte-activating receptor. It is involved in major aspects of NK immune function and shows a high degree of lineage specificity in blood and bone marrow.
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TMPY-01964 | CD16a Protein, Human, Recombinant (F176V, His) | Human | HEK293 Cells | ||
The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also known as CD16a, encodes a transmembrane protein expressed on activated monocytes/macrophages, natural killer (NK) cells, and a subset of T cells.
CD16a / FCGR3A is a receptor expressed on NK cells that facilitates antibody dependent cellular cytotoxicity (ADCC) by binding to the Fc portion of various antibodies. CD16a / FCGR3A also has a broader function. CD16a / FCGR3A is directly involved in the lysis of some virus-infected cells and tumor cells by NK cells, independent of antibody binding. Cross-linking of CD16a / FCGR3A on NK cells resulted in increased intracellular Ca2+ levels and a cascade of biochemical events similar to those activated by the T cell receptor. CD16a / FCGR3A on human NK cells is a lysis receptor that mediates the direct killing of some virus infected and tumor cells, independent of antibody ligation.
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TMPK-00091 | NKp30/NCR3 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
NKp30, along with NKp44 and NKp46, constitute a group of receptors termed "Natural Cytotoxicity Receptors". These receptors play a major role in triggering NK-mediated killing of most tumor cells lines.NKp30 stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells.
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TMPK-00090 | NKp30/NCR3 Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells | ||
NKp30, along with NKp44 and NKp46, constitute a group of receptors termed "Natural Cytotoxicity Receptors". These receptors play a major role in triggering NK-mediated killing of most tumor cells lines.NKp30 stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.
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TMPY-03623 | NKp80/KLRF1 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 Cells | ||
NKp80, also known as KLRF1, is an activating homodimeric C-type lectin-like receptor that is expressed on nearly all-natural killer cells and stimulates their cytotoxicity and cytokine release. NKp80 stimulates cytotoxicity upon engagement of its genetically linked ligand: myeloid-specific CTLR activation-induced C-type lectin (AICL). NKp80, but not NKp80 mutated at tyrosine 7 (NKp80/Y7F), is tyrosine phosphorylated. Accordingly, NKp80/Y7F, but not NKp80/Y3F or NKp80/Y37F, failed to induce cytotoxicity. NKp80 phosphopeptides comprising the Hemi-ITAM-like sequence surrounding tyrosine 7 bound Lck- and Syk-family kinases; accordingly, cross-linking of NKp8, but not NKp80/Y7F, induced Syk phosphorylation. Moreover, inhibition of Syk kinase, but not ZAP-7 kinase, impaired cytotoxic responses through NKp80. Atypical residues in the Hemi-ITAM-like motif of NKp80 cause an altered stoichiometry of phosphorylation but did not substantially affect NK cytotoxicity. Altogether, these results show that NKp80 uses an atypical Hemi-ITAM and Syk kinase to trigger cellular cytotoxicity.
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TMPK-00116 | NKp80/KLRF1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
NKp80, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on essentially all human natural killer (NK) cells and stimulates their cytotoxicity and cytokine release.
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TMPK-00598 | Fc gamma RIIIA/CD16a (V176) Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
The Human Fc gamma RIIIA/CD16a Protein is a receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.
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TMPK-01469 | HLA-A*02:01&B2M&MART-1 (ELAGIGILTV) Monomer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells | ||
Melanoma antigen recognized by T cell-1 (Mart-1), one of the melanosome-specific proteins, also recognized by cytotoxicity T lymphocytes as a marker. Mart-1 is considered to play a critical role in the immunotherapy for melanoma.
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TMPK-01468 | HLA-A*02:01&B2M&MART-1 (ELAGIGILTV) Tetramer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells | ||
Melanoma antigen recognized by T cell-1 (Mart-1), one of the melanosome-specific proteins, also recognized by cytotoxicity T lymphocytes as a marker. Mart-1 is considered to play a critical role in the immunotherapy for melanoma.
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TMPK-00136 | ULBP-2 Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells | ||
ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway, mediating natural killer cell cytotoxicity.
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TMPK-00260 | CD155/PVR Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells | ||
CD155 is a cell surface adhesion molecule functioning in tumor cell migration, invasion, and metastasis, and not surprisingly, is also designated as a common tumor-associated antigen. CD155 is also recognized by NK cells to induce their cytotoxicity. CD155 is also commonly referred to as the "poliovirus receptor," or PVR.
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TMPK-00597 | Fc gamma RIIIA/CD16a (V176) Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells | ||
Human Fc gamma RIIIA/CD16a Protein is a receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. Fc gamma RIIIA/CD16a (V176) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 24.7 kDa and the accession number is AAH17865.
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TMPY-05055 | GGH/Glutamyl hydrolase gamma Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
gamma-Glutamyl hydrolase (GGH) regulates intracellular folates and antifolates such as methotrexate (MTX) for proper nucleotide biosynthesis and antifolate-induced cytotoxicity, respectively. GGH is a ubiquitously-expressed enzyme that regulates intracellular folate metabolism for cell proliferation, DNA synthesis, and repair. cytoplasmic GGH might play a relevant role in the development and progression of invasive breast cancer.
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TMPK-00792 | Fc gamma RIIIA/CD16a (F176) Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
Human Fc gamma RIIIA/CD16a Protein is a receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. Fc gamma RIIIA/CD16a (F176) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 24.7 kDa and the accession number is P08637-1.
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TMPK-00599 | Fc gamma RIIIA/CD16a (V176) Domain 2 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells | ||
Human Fc gamma RIIIA/CD16a Protein is a receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. Fc gamma RIIIA/CD16a (V176) Domain 2 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 35.29 kDa and the accession number is AAH17865.
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TMPK-00791 | Fc gamma RIIIA/CD16a (F176) Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells | ||
Human Fc gamma RIIIA/CD16a Protein is a receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. Fc gamma RIIIA/CD16a (F176) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 24.7 kDa and the accession number is P08637-1.
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TMPK-00747 | NKp46/NCR1 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells | ||
NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. NKp46/NCR1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 52.9 kDa and the accession number is O76036-1.
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TMPK-01134 | NKp46/NCR1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. NKp46/NCR1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 27.4 kDa and the accession number is Q95JB9.
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TMPH-03036 | Cytotoxin 2 Protein, Naja atra, Recombinant (His & Myc) | Naja atra | E. coli | ||
Basic protein that binds to cell membrane and depolarizes cardiomyocytes. It also shows lytic activities, but 2-fold less important than that of CTX-A4. It binds to the integrin alpha-V/beta-3 (ITGAV/ITGB3) with a moderate affinity. It may interact with sulfatides in the cell membrane which induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It also may target the mitochondrial membrane and induce mitochondrial swelling and fragmentation.
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TMPK-00237 | 2B4/CD244 Protein, Human, Recombinant (aa 22-221, His & Avi), Biotinylated | Human | HEK293 Cells | ||
2B4 (CD244) is expressed by memory-phenotype CD8() T cells and all natural killer (NK) cells. The ligand for 2B4, CD48, is expressed on hematopoietic cells. 2B4 is conserved in humans and mice, and a number of reports have linked 2B4 with activation of lymphocytes.Engagement of 2B4 on NK cell surfaces with specific antibodies or CD48 can trigger cell mediated cytotoxicity, interferon γ secretion, phosphoinositol turnover and NK cell invasiveness.
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TMPK-00746 | NKp46/NCR1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. NKp46/NCR1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 53.2 kDa and the accession number is O76036-1.
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TMPK-01133 | NKp46/NCR1 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 Cells | ||
NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. NKp46/NCR1 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 53.1 kDa and the accession number is Q95JB9.
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TMPK-00614 | NKp46/NCR1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. NKp46/NCR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 27.5 kDa and the accession number is O76036-6.
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TMPK-00615 | NKp46/NCR1 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated | Human | HEK293 Cells | ||
NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. NKp46/NCR1 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 27.5 kDa and the accession number is O76036-6.
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TMPK-00460 | Fc gamma RIIIB/CD16b (NA2) Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
Human Fc gamma RIIIB/CD16b Protein is a receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils. Fc gamma RIIIB/CD16b (NA2) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 23.7 kDa and the accession number is O75015-1.
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TMPK-00459 | Fc gamma RIIIB/CD16b (NA2) Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells | ||
Human Fc gamma RIIIB/CD16b Protein is a receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils. Fc gamma RIIIB/CD16b (NA2) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 23.7 kDa and the accession number is O75015-1.
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TMPY-01561 | PIG3 Protein, Human, Recombinant (His) | Human | E. coli | ||
Nutlin-3 variably induces apoptosis and cell cycle arrest in cancer cells while it shows low/absent cytotoxicity in normal cells, Nutlin-3 is a promising anti-cancer agent, which exhibits activity against a variety of cancers, including acute myeloid leukemia (AML). The important role of TP53I3/PIG3 in mediating the apoptotic activity of Nutlin-3 was underlined by knock-down experiments with siRNA specific for TP53I3/PIG3, which resulted in a significant decrease in the pro-apoptotic activity of Nutlin-3.
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TMPH-02623 | DOCK8 Protein, Mouse, Recombinant (His) | Mouse | P. pastoris (Yeast) | ||
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing.
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TMPH-01207 | DOCK8 Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) | ||
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing.
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TMPH-02622 | DOCK8 Protein, Mouse, Recombinant (E. coli, His) | Mouse | E. coli | ||
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing.
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TMPJ-00175 | B7-H4 Protein, Rhesus macaque, Recombinant (hFc) | Rhesus | HEK293 Cells | ||
B7 Homolog 4 (B7-H4) is glycosylated member of the B7 family of immune costimulatory proteins.It is widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. It also involved in promoting epithelial cell transformation.
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TMPJ-00604 | KIR2DL4 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Killer cell immunoglobulin-like receptor 2DL4(KIR2DL4) is a Single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains.It belongs to the immunoglobulin superfamily. KIR2DL4 is expressed in all NK cells and some T cells. KIR2DL4 activates the cytotoxicity of NK cells, despite the presence of an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytoplasmic tail. The ITIM was not necessary for activation of lysis by KIR2DL4. The activation signal of KIR2DL4 was sensitive to inhibition by another ITIM-containing receptor. The activation-deficient mutant of KIR2DL4 inhibited the signal delivered by the activating receptor CD16.
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TMPK-00971 | CRTAM Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Class-I Restricted T Cell-Associated Molecule (CRTAM) is a protein that is expressed after T cell activation. The interaction of CRTAM with its ligand, nectin-like 2 (Necl2), is required for the efficient production of IL-17, IL-22, and IFNγ by murine CD4 T cells, and it plays a role in optimal CD8 T and NK cell cytotoxicity. CRTAM promotes the pro-inflammatory cytokine profile; therefore, it may take part in the immunopathology of autoimmune diseases such as diabetes type 1 or colitis. CRTAM Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 31.1 kDa and the accession number is Q149L7-1.
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