目录号 | 产品详情 | 靶点 | |
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T83930 | |||
SJ11646是一种高效的LCK(淋巴细胞特异性蛋白酪氨酸激酶)降解剂(PROTAC;DC50= 0.00838 pM)。该化合物由Dasatinib作为LCK配体,以及基于苯基谷氨酰亚胺的cereblon结合体组成。它在体外对LCK激活的T细胞急性淋巴细胞白血病(T-ALL)细胞株和初级白血病样本展现出细胞毒性。在体内,SJ11646在源自患者的T-ALL异种移植模型中显示出抗白血病效果。 | |||
T79731 | Necroptosis | ||
MLKL-IN-6(compound P28)是一种针对Mixed Lineage Kinase domain-like(MLKL)的混合谱系激酶抑制剂,具有抗纤维化的潜力。它能够抑制MLKL的磷酸化和寡聚化,从而抑制细胞坏死、免疫细胞死亡,并减少粘附因子的表达。MLKL-IN-6展现出低细胞毒性,并可抑制肝星状细胞的激活,从而降低肝纤维化标志物的水平。 | |||
T74762 | |||
Influenza A virus-IN-8 (S5) 为一种大环肽,无细胞毒性,并作为甲型流感病毒 (IAV) 的有效抑制剂,显示出较好的蛋白酶稳定性。其对 H1 和 H5 变体的IC50值分别低至 6.7 nM 和 6.6 nM。此外,Influenza A virus-IN-8 能够与 HA 茎的一个保守区域结合,特别是对 H1 变体展现出 1.0 nM 的高亲和性Kd 值。 | |||
T73422 | Topoisomerase | ||
CPT-Se4为含硒前体活性分子的喜树碱(CPT)衍生物,对癌细胞具有较高杀伤力和抑制肿瘤生长效果。在降低GSH/GSSG比率和总硫醇的同时,CPT-Se4能够增加Hep G2细胞中的ROS水平,触发癌细胞凋亡。此化合物对HeLa、Hep G2、A549和SMMC-7721细胞系显示出显著的细胞毒性,IC50值范围为2.54-6.4 μM。 | |||
T69985 | |||
Lifirafenib, also known as Beigene-283, is a Novel potent and selective RAF Kinase and EGFR inhibitor. BGB-283-displays Potent Antitumor Activity in B-RAF Mutated Colorectal Cancers. In vitro, BGB-283 potently inhibits B-RAFV600E-activated ERK phosphorylation and cell proliferation. It demonstrates selective cytotoxicity and preferentially inhibits proliferation of cancer cells harbouring B-RAFV600E and EGFR mutation/amplification. In B-RAFV600E CRC cell lines, BGB-283 effectively inhibits the reactivation of EGFR and EGFR-mediated cell proliferation. In vivo, BGB-283 treatment leads to dose-dependent tumor growth inhibition accompanied by partial and complete tumor regressions in both cell-line derived and primary human colorectal tumor xenografts bearing B-RAFV600E mutation. BGB-283 as a potent antitumor drug candidate with clinical potential for treating CRC harbouring B-RAFV600E mutation. | |||
T79558 | |||
fac-[Re(CO)3(L3)(H2O)][NO3](简称compound 3),是一种与线粒体功能障碍相关的抗前列腺癌剂。这种铼(I)三羰基水配合物对前列腺癌细胞系(PC-3)表现出显著的细胞毒性,其IC50值为0.32 μM。研究表明,fac-[Re(CO)3(L3)(H2O)][NO3]主要在线粒体中积聚,能够降低PC-3细胞的ATP生成,进而触发细胞副凋亡(paraptosis)机制,而不通过引发坏死、凋亡或自噬途径作用。 | |||
T62430 | |||
HIV-1 inhibitor-24 (compound S-12a) 是一种 HIV-1 逆转录 (HIV-1 RT) 的高效抑制剂 (IC50: 9.5 nM)。HIV-1 inhibitor-24 对野生型 HIV-1 表现出较高的抗病毒效果,其 EC50 值为 1.6 nM,且细胞毒性较低 (对 MT-4 细胞的 CC50 值为 9.07 μM)。HIV-1 inhibitor-24 在小鼠中 2 g/kg 剂量下具有良好的耐受性,并具有明显的心血管安全性。 | |||
T83853 | |||
L-K6L9 是由 L-亮氨酸和 L-赖氨酸的L-异构体组成的溶细胞肽。对LNCaP-CL1 雄激素独立型和22Rv1以及LNCaP雄激素依赖型人类前列腺癌细胞具有细胞毒性(LC50分别为4、4和6 µM),同时也对非癌性NIH3T3小鼠成纤维细胞和OL人类包皮成纤维细胞具有细胞毒性(LC50分别为7和5 µM)。在100 µM的浓度下,引起分离的人类红细胞溶血。 | |||
T83922 | |||
Pep2 peptide是一种针对跨膜糖蛋白CD36的肽配体,CD36也被称为清道夫受体B2。在1 mM浓度使用时,Pep2 peptide在无细胞检测中选择性地与CD36结合,相比于人血清白蛋白(HSA)、IgG和CD44具有更高的亲和力。与不含Pep2 peptide的胶束相比,包裹抗癌剂多柔比星的Pep2 peptide功能化胶束能增加多柔比星在过表达CD36的HepG2肝细胞癌细胞中的细胞内输送,并提升细胞毒性。 | |||
T62431 | |||
HIV-1 inhibitor-25 (compound R-12a) 是一种 HIV-1 逆转录 (HIV-1 RT) 的高效抑制剂 (IC50: 0.1061 nM)。HIV-1 inhibitor-25 对野生型 HIV-1 表现出较高的抗病毒效果,其 EC50 值为 13.6 nM,且细胞毒性较低 (对 MT-4 细胞的 CC50 值为 33.13 μM)。HIV-1 inhibitor-25 也能够抑制 HIV-1 突变株 (L100I, K103 N, Y181C, Y188L, E138K, F227L+V106A),EC50=0.1961 ~ 5.8136 μM。HIV-1 inhibitor-25 能够用于研究艾滋病。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-04616 | NKp30/NCR3 Protein, Cynomolgus, Rhesus, Recombinant (His) | Cynomolgus,Rhesus | HEK293 Cells | ||
NKp30/NCR3 Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.3 kDa and the accession number is XP_005553604.1.
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TMPY-05511 | NKp46/NCR1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
NKp46/NCR1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.6 kDa and the accession number is A0A0R4IZY7.
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TMPY-01807 | NKp44/NCR2 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
NKp44/NCR2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20 kDa and the accession number is O95944-1.
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TMPY-01145 | NKp30/NCR3 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
NKp30/NCR3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.4 kDa and the accession number is O14931-1.
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TMPY-00334 | NKp30/NCR3 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
NKp30/NCR3 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.2 kDa and the accession number is CAD23066.1.
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TMPY-03233 | NKp46/NCR1 Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
NKp46/NCR1 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 54.1 kDa and the accession number is Q9Z0H5.
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TMPY-04617 | B7-H6 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 Cells | ||
B7-H6 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 53.2 kDa and the accession number is XP_005578557.1.
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TMPY-04495 | B7-H6 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
B7-H6 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 35.1 kDa and the accession number is XP_006223356.1.
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TMPY-04618 | B7-H6 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
B7-H6 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.9 kDa and the accession number is XP_005578557.1.
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TMPY-00327 | B7-H6 Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
B7-H6 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 60.4 kDa and the accession number is XP_006223356.1.
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TMPY-06363 | B7-H6 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated | Cynomolgus | HEK293 Cells | ||
B7-H6 Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 29.76 kDa and the accession number is XP_005578557.1.
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TMPY-04619 | B7-H6 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
B7-H6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.1 kDa and the accession number is Q68D85.
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TMPY-05383 | NKp30/NCR3 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
NKp30/NCR3 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 39.6 kDa and the accession number is O14931-3.
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TMPY-00377 | B7-H6 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
B7-H6 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 53.4 kDa and the accession number is Q68D85.
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TMPY-06178 | B7-H6 Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 Cells | ||
B7-H6 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 28.1 kDa and the accession number is Q68D85.
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TMPY-05367 | NKp44/NCR2 Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 Cells | ||
NKp44/NCR2 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20 kDa and the accession number is O95944-1.
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TMPJ-00083 | NCR3 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
Natural Cytotoxicity Triggering Receptor 3 (NCR3) along with NKp44 and NKp46 constitute a group of receptors termed “Natural Cytotoxicity Receptors”. They play a major role in triggering NK-mediated killing of most tumor cells lines. NKp30 is a type I transmembrane protein having a single extracellular V-like immunoglobulin domain. NKp30 is selectively expressed both in resting and activated human NK cells. In addition, NKp30 is also involved in NK-mediated induction of dendritic cell (DC) maturation. It has been demonstrated that NK cell activation signaling specifically induces lytic activity against several tumor cell types and synthesis of new NF-κB dependent proteins during the initiation of cytotoxicity.
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TMPJ-00567 | NCR1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
Natural cytotoxicity triggering receptor 1(NCR1) is a single-pass type I membrane protein .It contains 2 Ig-like (immunoglobulin-like) domains and belongs to the natural cytotoxicity receptor (NCR) family. The protein is a natural killer (NK) lymphocyte-activating receptor. It is involved in major aspects of NK immune function and shows a high degree of lineage specificity in blood and bone marrow.
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TMPY-01964 | CD16a Protein, Human, Recombinant (F176V, His) | Human | HEK293 Cells | ||
The Fc receptor with low affinity for IgG (FCGR3, or CD16) is encoded by 2 nearly identical genes, FCGR3A and FCGR3B, resulting in tissue-specific expression of alternative membrane-anchored isoforms. FCGR3A, it is also known as CD16a, encodes a transmembrane protein expressed on activated monocytes/macrophages, natural killer (NK) cells, and a subset of T cells.
CD16a / FCGR3A is a receptor expressed on NK cells that facilitates antibody dependent cellular cytotoxicity (ADCC) by binding to the Fc portion of various antibodies. CD16a / FCGR3A also has a broader function. CD16a / FCGR3A is directly involved in the lysis of some virus-infected cells and tumor cells by NK cells, independent of antibody binding. Cross-linking of CD16a / FCGR3A on NK cells resulted in increased intracellular Ca2+ levels and a cascade of biochemical events similar to those activated by the T cell receptor. CD16a / FCGR3A on human NK cells is a lysis receptor that mediates the direct killing of some virus infected and tumor cells, independent of antibody ligation.
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TMPK-00091 | NKp30/NCR3 Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
NKp30, along with NKp44 and NKp46, constitute a group of receptors termed "Natural Cytotoxicity Receptors". These receptors play a major role in triggering NK-mediated killing of most tumor cells lines.NKp30 stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells.
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TMPK-00090 | NKp30/NCR3 Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells | ||
NKp30, along with NKp44 and NKp46, constitute a group of receptors termed "Natural Cytotoxicity Receptors". These receptors play a major role in triggering NK-mediated killing of most tumor cells lines.NKp30 stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.
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TMPY-03623 | NKp80/KLRF1 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 Cells | ||
NKp80, also known as KLRF1, is an activating homodimeric C-type lectin-like receptor that is expressed on nearly all-natural killer cells and stimulates their cytotoxicity and cytokine release. NKp80 stimulates cytotoxicity upon engagement of its genetically linked ligand: myeloid-specific CTLR activation-induced C-type lectin (AICL). NKp80, but not NKp80 mutated at tyrosine 7 (NKp80/Y7F), is tyrosine phosphorylated. Accordingly, NKp80/Y7F, but not NKp80/Y3F or NKp80/Y37F, failed to induce cytotoxicity. NKp80 phosphopeptides comprising the Hemi-ITAM-like sequence surrounding tyrosine 7 bound Lck- and Syk-family kinases; accordingly, cross-linking of NKp8, but not NKp80/Y7F, induced Syk phosphorylation. Moreover, inhibition of Syk kinase, but not ZAP-7 kinase, impaired cytotoxic responses through NKp80. Atypical residues in the Hemi-ITAM-like motif of NKp80 cause an altered stoichiometry of phosphorylation but did not substantially affect NK cytotoxicity. Altogether, these results show that NKp80 uses an atypical Hemi-ITAM and Syk kinase to trigger cellular cytotoxicity.
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TMPK-00116 | NKp80/KLRF1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
NKp80, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on essentially all human natural killer (NK) cells and stimulates their cytotoxicity and cytokine release.
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TMPK-00598 | Fc gamma RIIIA/CD16a (V176) Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
The Human Fc gamma RIIIA/CD16a Protein is a receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.
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TMPK-01469 | HLA-A*02:01&B2M&MART-1 (ELAGIGILTV) Monomer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells | ||
Melanoma antigen recognized by T cell-1 (Mart-1), one of the melanosome-specific proteins, also recognized by cytotoxicity T lymphocytes as a marker. Mart-1 is considered to play a critical role in the immunotherapy for melanoma.
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TMPK-01468 | HLA-A*02:01&B2M&MART-1 (ELAGIGILTV) Tetramer Protein, Human, MHC (His & Avi) | Human | HEK293 Cells | ||
Melanoma antigen recognized by T cell-1 (Mart-1), one of the melanosome-specific proteins, also recognized by cytotoxicity T lymphocytes as a marker. Mart-1 is considered to play a critical role in the immunotherapy for melanoma.
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TMPK-00136 | ULBP-2 Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells | ||
ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway, mediating natural killer cell cytotoxicity.
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TMPK-00260 | CD155/PVR Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells | ||
CD155 is a cell surface adhesion molecule functioning in tumor cell migration, invasion, and metastasis, and not surprisingly, is also designated as a common tumor-associated antigen. CD155 is also recognized by NK cells to induce their cytotoxicity. CD155 is also commonly referred to as the "poliovirus receptor," or PVR.
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TMPK-00597 | Fc gamma RIIIA/CD16a (V176) Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells | ||
Human Fc gamma RIIIA/CD16a Protein is a receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. Fc gamma RIIIA/CD16a (V176) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 24.7 kDa and the accession number is AAH17865.
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TMPY-05055 | GGH/Glutamyl hydrolase gamma Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
gamma-Glutamyl hydrolase (GGH) regulates intracellular folates and antifolates such as methotrexate (MTX) for proper nucleotide biosynthesis and antifolate-induced cytotoxicity, respectively. GGH is a ubiquitously-expressed enzyme that regulates intracellular folate metabolism for cell proliferation, DNA synthesis, and repair. cytoplasmic GGH might play a relevant role in the development and progression of invasive breast cancer.
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TMPK-00792 | Fc gamma RIIIA/CD16a (F176) Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
Human Fc gamma RIIIA/CD16a Protein is a receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. Fc gamma RIIIA/CD16a (F176) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 24.7 kDa and the accession number is P08637-1.
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TMPK-00791 | Fc gamma RIIIA/CD16a (F176) Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells | ||
Human Fc gamma RIIIA/CD16a Protein is a receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. Fc gamma RIIIA/CD16a (F176) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 24.7 kDa and the accession number is P08637-1.
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TMPK-00599 | Fc gamma RIIIA/CD16a (V176) Domain 2 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells | ||
Human Fc gamma RIIIA/CD16a Protein is a receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. Fc gamma RIIIA/CD16a (V176) Domain 2 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 35.29 kDa and the accession number is AAH17865.
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TMPK-00747 | NKp46/NCR1 Protein, Human, Recombinant (mFc) | Human | HEK293 Cells | ||
NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. NKp46/NCR1 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with C-mFc tag. The predicted molecular weight is 52.9 kDa and the accession number is O76036-1.
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TMPK-01134 | NKp46/NCR1 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. NKp46/NCR1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 27.4 kDa and the accession number is Q95JB9.
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TMPH-03036 | Cytotoxin 2 Protein, Naja atra, Recombinant (His & Myc) | Naja atra | E. coli | ||
Basic protein that binds to cell membrane and depolarizes cardiomyocytes. It also shows lytic activities, but 2-fold less important than that of CTX-A4. It binds to the integrin alpha-V/beta-3 (ITGAV/ITGB3) with a moderate affinity. It may interact with sulfatides in the cell membrane which induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It also may target the mitochondrial membrane and induce mitochondrial swelling and fragmentation.
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TMPK-00237 | 2B4/CD244 Protein, Human, Recombinant (aa 22-221, His & Avi), Biotinylated | Human | HEK293 Cells | ||
2B4 (CD244) is expressed by memory-phenotype CD8() T cells and all natural killer (NK) cells. The ligand for 2B4, CD48, is expressed on hematopoietic cells. 2B4 is conserved in humans and mice, and a number of reports have linked 2B4 with activation of lymphocytes.Engagement of 2B4 on NK cell surfaces with specific antibodies or CD48 can trigger cell mediated cytotoxicity, interferon γ secretion, phosphoinositol turnover and NK cell invasiveness.
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TMPK-00746 | NKp46/NCR1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. NKp46/NCR1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 53.2 kDa and the accession number is O76036-1.
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TMPK-01133 | NKp46/NCR1 Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 Cells | ||
NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. NKp46/NCR1 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 53.1 kDa and the accession number is Q95JB9.
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TMPK-00614 | NKp46/NCR1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. NKp46/NCR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 27.5 kDa and the accession number is O76036-6.
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TMPK-00615 | NKp46/NCR1 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated | Human | HEK293 Cells | ||
NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. NKp46/NCR1 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 27.5 kDa and the accession number is O76036-6.
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TMPK-00460 | Fc gamma RIIIB/CD16b (NA2) Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
Human Fc gamma RIIIB/CD16b Protein is a receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils. Fc gamma RIIIB/CD16b (NA2) Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 23.7 kDa and the accession number is O75015-1.
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TMPK-00459 | Fc gamma RIIIB/CD16b (NA2) Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells | ||
Human Fc gamma RIIIB/CD16b Protein is a receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils. Fc gamma RIIIB/CD16b (NA2) Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 23.7 kDa and the accession number is O75015-1.
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TMPY-01561 | PIG3 Protein, Human, Recombinant (His) | Human | E. coli | ||
Nutlin-3 variably induces apoptosis and cell cycle arrest in cancer cells while it shows low/absent cytotoxicity in normal cells, Nutlin-3 is a promising anti-cancer agent, which exhibits activity against a variety of cancers, including acute myeloid leukemia (AML). The important role of TP53I3/PIG3 in mediating the apoptotic activity of Nutlin-3 was underlined by knock-down experiments with siRNA specific for TP53I3/PIG3, which resulted in a significant decrease in the pro-apoptotic activity of Nutlin-3.
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TMPH-02623 | DOCK8 Protein, Mouse, Recombinant (His) | Mouse | P. pastoris (Yeast) | ||
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing.
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TMPH-01207 | DOCK8 Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) | ||
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing.
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TMPH-02622 | DOCK8 Protein, Mouse, Recombinant (E. coli, His) | Mouse | E. coli | ||
Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing.
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TMPJ-00175 | B7-H4 Protein, Rhesus macaque, Recombinant (hFc) | Rhesus | HEK293 Cells | ||
B7 Homolog 4 (B7-H4) is glycosylated member of the B7 family of immune costimulatory proteins.It is widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. It also involved in promoting epithelial cell transformation.
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TMPJ-00604 | KIR2DL4 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Killer cell immunoglobulin-like receptor 2DL4(KIR2DL4) is a Single-pass type I membrane protein and contains 2 Ig-like C2-type (immunoglobulin-like) domains.It belongs to the immunoglobulin superfamily. KIR2DL4 is expressed in all NK cells and some T cells. KIR2DL4 activates the cytotoxicity of NK cells, despite the presence of an immunoreceptor tyrosine-based inhibition motif (ITIM) in its cytoplasmic tail. The ITIM was not necessary for activation of lysis by KIR2DL4. The activation signal of KIR2DL4 was sensitive to inhibition by another ITIM-containing receptor. The activation-deficient mutant of KIR2DL4 inhibited the signal delivered by the activating receptor CD16.
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TMPK-01385 | CRTAM Protein, Canine, Recombinant (His) | Canine | HEK293 Cells | ||
Class-I Restricted T Cell-Associated Molecule (CRTAM) is a protein that is expressed after T cell activation. The interaction of CRTAM with its ligand, nectin-like 2 (Necl2), is required for the efficient production of IL-17, IL-22, and IFNγ by murine CD4 T cells, and it plays a role in optimal CD8 T and NK cell cytotoxicity. CRTAM promotes the pro-inflammatory cytokine profile; therefore, it may take part in the immunopathology of autoimmune diseases such as diabetes type 1 or colitis. CRTAM Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 31.19 kDa and the accession number is E2QWY2.
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