目录号 | 产品详情 | 靶点 | |
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T82474 | |||
Empasiprubart (ARGX-117) 是一种针对补体 C2 的人源化抑制性单克隆抗体。该抗体通过结合 C2 的 Sushi-2 结构域来阻止 C3 原转化酶的形成,进而抑制 C3 的激活,并阻断经典途径与凝集素途径的上游激活。Empasiprubart 展现出 pH 和钙依赖性的靶标结合能力,并在自身免疫性溶血性贫血以及抗体介导的器官移植排斥模型中,预防了补体介导的细胞毒性作用。 | |||
T76210 | |||
POT-4 TFA (AL-78898A TFA),Compstatin 衍生物,有效抑制补体因子 C3 激活,适应于年龄相关黄斑变性研究。 | |||
T3S0964 | Others | ||
Chrysoeriol-7-O-glucoside can strongly inhibit the classical pathway of the complement system.Chrysoeriol-7-O-d-glucoside and luteolin-7-O-d-glucoside can inhibit palmitic acid uptake into small intestinal brush border membrane, apigenin-7-O-d-glucoside can inhibit alpha-amylase activity; they can enhance norepinephrine-induced lipolysis in fat cells. | |||
T80083 | Complement System | ||
Zilucoplan TFA (RA101495)为含15个氨基酸的大环肽,有效抑制补体组分5 (C5)。该化合物适用于免疫介导的坏死性肌病 (IMNM) 研究。 | |||
T80882 | |||
Val-Gly-Ser-Glu (NSC 350591) 是一种ECF-A四肽。该化合物能剂量依赖性地提升人类嗜酸性粒细胞的数量,而不影响中性粒细胞的数量,并可与补体包被的绵羊红细胞(EAC3b)形成玫瑰花结。 | |||
T78191 | Complement System | ||
NH2-C6-ARC186是带有NH2-C6接头的ARC186衍生物,可用于与其他肽或分子偶联。它作为一种适体,是一种高效的补体抑制剂,通过抑制转化酶催化的C5活化发挥作用。 | |||
T82331 | |||
Gavilimomab (ABX-CBL)为IgM亚型小鼠单克隆抗体,针对细胞表面的CD147进行特异性识别,并通过激活补体系统引发的细胞裂解实现细胞杀伤作用。该抗体主要用于移植物抗宿主病(GVHD)研究领域。 | |||
T74683 | |||
IONIS-FB-LRx 是一种靶向补体因子 B (CFB) 的特殊反义寡核苷酸(ASO)。IONIS-FB-LRx 能有效降低 CFB 的循环水平。IONIS-FB-LRx 可用于地理萎缩 (GA) 研究。 | |||
T74650 | |||
JPE-1375 是一种补体C5a 受体 1 (C5aR1) 拮抗剂。JPE-1375 能有效抑制小鼠体内多形核白细胞动员 (EC50=6.9 µM) 和降低TNF 水平 (EC50=4.5 µM)。JPE-1375 可用于自身免疫性和炎性疾病的研究。 | |||
T75815 | |||
WKYMVM-NH2 TFA 是一种高效的 N-甲酰肽受体 FPR1 与 FPRL1/2 激动剂,具备激活白细胞功效特性,包括趋化性、补体受体-3 的激活以及 NADPH 氧化酶的激活。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-00653 | Complement C5 Protein, Human, Recombinant (Complement C5a) | Human | E. coli | ||
Complement C5 Protein, Human, Recombinant (Complement C5a) is expressed in E. coli expression system. The predicted molecular weight is 8.3 kDa and the accession number is P01031.
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TMPY-05732 | Complement C3 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
Complement C3 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 186.40 kDa and the accession number is XP_005587776.1.
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TMPY-04902 | Complement C5a Protein, Mouse, Recombinant | Mouse | E. coli | ||
Complement C5a Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 9 kDa and the accession number is P06684.
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TMPY-05057 | Complement C5 Protein, Human, Recombinant (His & FLAG) | Human | HEK293 Cells | ||
Complement C5 Protein, Human, Recombinant (His & FLAG) is expressed in HEK293 mammalian cells with His and Flag tag. The predicted molecular weight is 188.8 kDa and the accession number is P01031.
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TMPY-00686 | Complement C2 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Complement C2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82.5 kDa and the accession number is P06681-1.
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TMPY-05731 | Complement C3 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Complement C3 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 186.43 kDa and the accession number is P01024.
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TMPY-04921 | Complement factor B/CFB Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Complement factor B/CFB Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.5 kDa and the accession number is AAH04143.1.
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TMPY-02892 | Complement C7 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Complement C7 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 92.6 kDa and the accession number is P10643.
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TMPY-06538 | Complement C5 Protein, Cynomolgus, Recombinant | Cynomolgus | HEK293 Cells | ||
Complement C5 Protein, Cynomolgus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 8.41 kDa and the accession number is XP_005580972.1.
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TMPY-03012 | Complement C7 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
Complement C7 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 118 kDa and the accession number is P10643.
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TMPY-06137 | Complement C5 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
Complement C5 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 188.1 kDa and the accession number is XP_005580972.1.
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TMPY-02641 | Complement C6 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Complement C6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 104 kDa and the accession number is AAA59668.1.
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TMPJ-00417 | Complement C3a Protein, Human, Recombinant | Human | E. coli | ||
Complement C3a Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 13 KDa and the accession number is P01024.
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TMPY-05459 | Complement C5a Protein, Mouse, Recombinant, Biotinylated | Mouse | E. coli | ||
Complement C5a Protein, Mouse, Recombinant, Biotinylated is expressed in E. coli expression system. The predicted molecular weight is 9 kDa and the accession number is P06684.
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TMPY-03447 | Complement C2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Complement C2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.2 kDa and the accession number is P21180-1.
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TMPJ-00416 | Complement C3a Protein, Mouse, Recombinant | Mouse | E. coli | ||
Complement C3a Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 9 KDa and the accession number is P01027.
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TMPY-06814 | Complement C5 Protein, Human, Recombinant (Flag) | Human | HEK293 Cells | ||
Complement C5 Protein, Human, Recombinant (Flag) is expressed in HEK293 mammalian cells with Flag tag. The predicted molecular weight is 187.36 kDa and the accession number is NP_001726.2.
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TMPJ-00585 | Complement C8 gamma Protein, Human, Recombinant (His) | Human | E. coli | ||
Complement component C8 is a constituent of the membrane attack complex, C8 alpha, C8 beta and C8G. C8G is a secreted protein and comsists a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 alpha and C8 beta play an important role in complement-mediated bacterial killing together.C8 is involved in the formation of Membrane Attack Complex on bacterial cell membranes. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. Patients lacking C8 are susceptible to certain bacterial infections.
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TMPH-03270 | Complement C5 Protein, Rat, Recombinant (His & Myc) | Rat | E. coli | ||
Complement C5 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 14.0 kDa and the accession number is P08650.
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TMPH-01132 | Complement C8a Protein, Human, Recombinant (His) | Human | E. coli | ||
Complement C8a Protein, Human, Recombinant (His) is expressed in E. coli.
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TMPH-01133 | Complement C8b Protein, Human, Recombinant (His) | Human | E. coli | ||
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Complement C8b Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 67.0 kDa and the accession number is P07358.
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TMPH-03107 | Complement C5a Protein, Pig, Recombinant (His) | Sus scrofa (Pig) | P. pastoris (Yeast) | ||
Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. Complement C5a Protein, Pig, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 10.6 kDa and the accession number is P01032.
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TMPH-02604 | Complement C3 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli | ||
Complement C3 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 55.3 kDa and the accession number is P01027.
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TMPH-01134 | Complement C8g Protein, Human, Recombinant (His) | Human | E. coli | ||
C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. Complement C8g Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 26.4 kDa and the accession number is P07360.
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TMPY-00687 | Complement C2 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
Complement C2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 110 kDa and the accession number is P06681-1.
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TMPH-00231 | Complement C3 Protein, Bovine, Recombinant (His & SUMO) | Bovine | E. coli | ||
Complement C3 Protein, Bovine, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 39.5 kDa and the accession number is Q2UVX4.
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TMPY-06767 | Complement C3 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Complement C3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 36.34 kDa and the accession number is NP_033908.2.
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TMPY-04141 | Complement factor H/CFH Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
Complement factor H/CFH Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 69.1 kDa and the accession number is E9Q8I0.
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TMPK-01268 | Complement C2 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
Single nucleotide polymorphism (SNP) of complement component 2 (C2) has been found to be significantly associated with hepatocellular carcinoma (HCC). Significantly lower C2 expression was found at HCC compared to healthy controls, and C2 was associated with TNM stages. Higher C2 expression was significantly associated with better prognosis, and multivariate analysis showed that C2 was also an independent factor for the prognosis of HCC.
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TMPY-04129 | Complement factor H/CFH Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Complement factor H/CFH Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.8 kDa and the accession number is E9Q8I0.
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TMPH-03273 | Complement factor I Protein, Rat, Recombinant (His & Myc) | Rat | Baculovirus Insect Cells | ||
Complement factor I Protein, Rat, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 69.2 kDa and the accession number is Q9WUW3.
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TMPJ-00980 | Complement Factor MASP3 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
MASP3 is a member of the MASPs involved in mannan-binding lectin (MBL) complement pathway. The MBL pathway is initiated by the binding of MBL to specific carbohydrate structures found on the surface of a variety of microorganisms. Activation of the complement pathway via MBL is initiated by specific MASPs. Three MASPs have been identified and all have domain structures similar to those of C1r and C1s with a heavy chain (chain A) and a light chain (chain B). Chain A is composed of CUB1, EGF, CUB2, CCP1 and CCP2 while chain B corresponds to the catalytic domain found in many serine proteases. MASP1 and MASP3 are two alternatively spliced products of a single gene, which contain the same A chains but entirely different B chains. Distinct MASPs found in different MBL oligomers may have different biological activities. For example, MASP3, found together with MASP2, downregulates the C4 and C2 cleaving activity of MASP2. The protease activity of MASP3 is first revealed here using rhMASP3CD, which is inhibited by serine protease inhibitors such as Ecotin and AEBSF.
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TMPY-02167 | Complement Factor D/CFD Protein, Mouse, Recombinant (His,HEK293) | Mouse | HEK293 Cells | ||
Complement Factor D/CFD Protein, Mouse, Recombinant (His,HEK293) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 27.4 kDa and the accession number is P03953-2.
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TMPY-02183 | Complement Factor D/CFD Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Complement Factor D/CFD Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.8 kDa and the accession number is P00746.
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TMPH-02605 | Complement C4-B Protein, Mouse, Recombinant (His) | Mouse | E. coli | ||
Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. Catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.
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TMPH-02607 | Complement factor B Protein, Mouse, Recombinant (His) | Mouse | E. coli | ||
Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase.
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TMPK-01023 | Complement factor I Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Complement factor I (CFI) is a serine protease which plays a key role in the modulation of complement system and the induced-fit factor responsible for controlling the complement-mediated processes. Complement factor I Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 66.39 kDa and the accession number is Q61129.
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TMPK-00776 | Complement factor I Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Complement factor I (CFI) is a serine protease which plays a key role in the modulation of complement system and the induced-fit factor responsible for controlling the complement-mediated processes. Complement factor I Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 64.58 kDa and the accession number is P05156.
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TMPH-01131 | Complement C4-B Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
Complement C4-B Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
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TMPH-03272 | Complement factor D Protein, Rat, Recombinant (His) | Rat | P. pastoris (Yeast) | ||
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
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TMPJ-00149 | Complement Factor D/CFD Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
Complement factor D, also known as adipsin, is a member of the chymotrypsin family of serine proteases, which plays an essential role in host defense as the rate-limiting enzyme in the alternative pathway of complement activation. Complement factor D activates a convertase (C3bBb) responsible for cleavage of the complement protein C3, which leads to the activation of terminal complement component C5-9 to form the membrane attack complex on microbial or cellular surfaces. It also functions in the regulation of systemic energy balance and physiologic and pathologic processes, including immunity and inflammation.
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TMPK-00755 | Complement Factor D/CFD Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli suggesting that this component of the complement cascade could influence renal pathophysiology.Complement factor D or alternative pathway activation is needed to prevent spontaneous accumulation of C3 and IgM deposits within the mesangium. Complement Factor D/CFD Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 51.2 kDa and the accession number is P00746-1.
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TMPH-03271 | Complement factor D Protein, Rat, Recombinant (His & Myc) | Rat | HEK293 Cells | ||
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. Complement factor D Protein, Rat, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 29.8 kDa and the accession number is P32038.
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TMPK-00671 | Complement Factor D/CFD Protein, Rhesus macaque, Recombinant (His) | Rhesus | HEK293 Cells | ||
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli suggesting that this component of the complement cascade could influence renal pathophysiology.Complement factor D or alternative pathway activation is needed to prevent spontaneous accumulation of C3 and IgM deposits within the mesangium. Complement Factor D/CFD Protein, Rhesus macaque, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 25.7 kDa and the accession number is H9EXC1-1.
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TMPK-00790 | Complement factor H/CFH Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Factor H is the major soluble inhibitor of complement, where its binding to self markers (i.e., particular glycan structures) prevents complement activation and amplification on host surfaces. Not surprisingly, mutations and polymorphisms that affect recognition of self by factor H are associated with diseases of complement dysregulation, such as age-related macular degeneration and atypical haemolytic uremic syndrome. In addition, pathogens (i.e., non-self) and cancer cells (i.e., altered-self) can hijack factor H to evade the immune response.
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TMPK-00151 | Complement Factor D/CFD Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
Complement factor D is a serine protease essential for the activation of the alternative pathway and is expressed in the kidney, adipocytes, and macrophages. Factor D is found at relatively high levels in glomeruli suggesting that this component of the complement cascade could influence renal pathophysiology.Complement factor D or alternative pathway activation is needed to prevent spontaneous accumulation of C3 and IgM deposits within the mesangium. Complement Factor D/CFD Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 52.2 kDa and the accession number is P03953-1.
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TMPJ-00809 | CFH Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Complement Factor H (CFH) is a secreted protein which is a member of the regulators of complement activation family and is a complement control protein. It is expressed by the liver and secreted in plasma. Its principal function is to regulate the Alternative Pathway of the complement system, ensuring that the complement system is directed towards pathogens or other dangerous material and does not damage host tissue. Factor H regulates complement activation on self cells and surfaces by possessing both cofactor activity for the Factor I mediated C3b cleavage, and decay accelerating activity against the alternative pathway C3-convertase, C3bBb. Factor H exerts its protective action on self cells and self surfaces but not on the surfaces of bacteria or viruses, because it binds to glycosaminoglycans (GAGs) that are generally present on host cells but not, normally, on pathogen surfaces.
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TMPH-02603 | C1SB Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli | ||
C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.
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TMPH-02602 | C1RA Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli | ||
C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.
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TMPY-06695 | C1QA Protein, Human, Recombinant (GST) | Human | E. coli | ||
C1QA Protein, Human, Recombinant (GST) is expressed in E. coli expression system with GST tag. The predicted molecular weight is 50.58 kDa and the accession number is P02745.
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