目录号 | 产品详情 | 靶点 | |
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T61935 | |||
B-Raf IN 9 (compound 8b) 是有效的B-Raf 抑制剂(IC50= 24.79 nM)。B-Raf IN 9 将细胞周期阻滞于 G2/M 期,诱导凋亡。B-Raf IN 9 对人前列腺癌 PC-3 细胞表现出较强的抗肿瘤活性(IC50= 7.83 μM)。 | |||
T63855 | |||
B-Raf IN 6 是蛋白激酶 B-Raf 的有效抑制剂 (IC50: 1.7 nM)。B-Raf IN 6 不结合二级靶点 PXR,并可抵抗快速代谢。B-Raf IN 6 对癌症疾病表现出研究潜力。 | |||
T60727 | |||
B-Raf IN 8 (compound 7g) 是 B-Raf 的有效抑制剂 (IC50 = 70.65 nM)。B-Raf IN 8 显示出抗肿瘤活性,其对肝细胞癌 (HEPG-2)、结肠癌 (HCT-116),乳腺癌 (MCF-7) 和人前列腺癌 (PC-3) 细胞的 IC50值分别为9.78、13.78、18.52 和 29.85 μM。 | |||
T63386 | |||
Pan-RAF kinase inhibitor 1 是 Pan-RAF 激酶对有效抑制剂, 能够抑制 RAF 激酶,调节 MAPK 信号传导,进而影响 RAS 突变肿瘤细胞的增殖。 Pan-RAF kinase inhibitor 1 对研究癌症疾病表现出研究潜力。 | |||
T72605 | |||
C-RAFkinase-IN-1 是一种有效的C-RAF 激酶抑制剂,IC50为 0.193 μM。C-RAFkinase-IN-1 是一种喹啉衍生物。C-RAFkinase-IN-1 具有研究癌症疾病的潜力。 | |||
T10157 | Raf VEGFR c-RET PDGFR c-Kit Drug Metabolite | ||
Regorafénib N-oxyde M2 是 Regorafenib 的活性代谢物。Regorafenib 是多靶点抑制剂,包括VEGFR1/2/3,PDGFRβ,Kit,RET 和 Raf-1 , IC50分别是 13/4.2/46,22,7,1.5 和 2.5 nM。 | |||
T8654 | Raf | ||
Plx-4032 (Vemurafenib) 是一种小分子 B-Raf 抑制剂,可用于治疗恶性黑色素瘤。 | |||
T1876 | Apoptosis Raf Ras | ||
Kobe0065 是一种新型 Ras-Raf 相互作用抑制剂,可完全抑制 H-Ras·GTP 与 c-Raf-1 RBD 的结合,Ki 值为 46±13 μM。 | |||
T6348 | Raf Bcr-Abl Src Ephrin Receptor | ||
NVP-BHG712 是一种特异性的 EphB4 抑制剂,ED50=25 nM,可区分 VEGFR 和 EphB4 抑制。它还显示对 c-Raf (IC50:0.395 μM)、c-Src (IC50:1.266 μM) 和 c-Abl (IC50:1.667 μM) 的活性。 | |||
T16909 | Raf VEGFR | ||
Donafenib (Bay 43-9006 (D3)) 是一种氘标记的 Sorafenib,Sorafenib 是一种多激酶抑制剂(对 Raf-1、B-Raf 和 VEGFR-3 的 IC50 分别为 6 nM、20 nM 和 22 nM)。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-05095 | RAF1 Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells | ||
RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
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TMPH-01995 | RAF1 Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
RAF1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 89.1 kDa and the accession number is P04049.
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TMPY-00146 | RKIP/PEBP1 Protein, Human, Recombinant | Human | E. coli | ||
Phosphatidylethanolamine-binding protein 1 (PEBP1), also known as Raf kinase inhibitor protein, belongs to PEBP family of proteins. It is known to interact with many proteins that are mainly involved in pathways that monitor cell proliferation and differentiation. PEBP1 in many cells interacts with several pathways, namely MAPK, GRK2, NF-small ka, CyrillicB, etc. that keeps the cell proliferation and differentiation in check. This protein is expressed by many cells in humans, including neurons where it is predominantly involved in production of choline acetyltransferase. Deregulated PEBP1 is known to cause cancer, diabetic nephropathy and neurodegenerative diseases like Alzheimer's and dementia.
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TMPY-04411 | YES1 Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells | ||
Proto-oncogene tyrosine-protein kinase Yes, also known as Proto-oncogene c-Yes, p61-Yes and YES1, is a cytoplasm protein that belongs to the protein kinase superfamily, Tyr protein kinase family and SRC subfamily. YES1 / c-Yes contains one protein kinase domain, one SH2 domain and one SH3 domain. It is thought that the subcellular distribution of Src-family tyrosine kinases, including c-Yes binding to the cellular membrane, is membranous and/or cytoplasmic. YES1 / c-Yes protein tyrosine kinase is known to be related to malignant transformation. YES1 / c-Yes and c-Src are the two most closely related members of the Src family of nonreceptor tyrosine kinases. Although there is much evidence to support redundancy in signaling between these two kinases. YES1 / c-Yes promotes the formation of the tight junction by phosphorylating occludin, while c-Src signaling downregulates occludin formation in a Raf-1 dependent manner. YES1 / c-Yes has tyrosine kinase activity. It promotes infectivity of Neisseria gonorrhoeae in epithelial cells by phosphorylating MCP / CD46.
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