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RAF1 Protein, Human, Recombinant (His & GST)

RAF1 Protein, Human, Recombinant (His & GST)

产品编号 TMPY-05095
别名: Raf-1 proto-oncogene, serine/threonine kinase, CRAF, NS5, CMD1NN, Raf-1, c-Raf

RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

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RAF1 Protein, Human, Recombinant (His & GST)
规格 价格/CNY 货期 数量
50 μg ¥ 3,170 5日内发货
千万补贴 助力科研
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产品目录号及名称: RAF1 Protein, Human, Recombinant (His & GST) (TMPY-05095)
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生物活性 Testing in progress
产品描述 RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
种属 Human
表达系统 Baculovirus-Insect Cells
标签 His,GST
蛋白编号 L7RRS6
别名 Raf-1 proto-oncogene, serine/threonine kinase, CRAF, NS5, CMD1NN, Raf-1, c-Raf
蛋白构建 A DNA sequence encoding the human RAF1 (NP_002871.1) (Ser306-Phe648) was expressed with a N-terminal GST tagged polyhistidine tag at the N-terminus.
蛋白纯度 > 70 % as determined by SDS-PAGE.
分子量 66.9 kDa (predicted)
内毒素 < 1.0 EU per μg protein as determined by the LAL method.
缓冲液 Lyophilized from sterile 20 mM Tris, 500 mM Nacl, pH 8.0, 10 % glycerol, 0. 5 mM TCEP, 2 mM GSH. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0. 01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
复溶方法 A hardcopy of datasheet with reconstitution instructions is sent along with the products. Please refer to it for detailed information.
存储

Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

运输方式

In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

研究背景 RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

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Keywords

RAF1 Protein, Human, Recombinant (His & GST) Raf-1 proto-oncogene, serine/threonine kinase CRAF NS5 CMD1NN Raf-1 NS-5 c-Raf NS 5 recombinant recombinant-proteins proteins protein

 

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