Ras | 陶素生化

Ras

T6163	Salirasib	Salirasib(Ki=2.6 μM), an effective competitive prenylated protein methyltransferase (PPMTase) inhibitor, inhibits Ras methylation with potential antineoplastic activity.
T6302	Lonafarnib	Lonafarnib is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B, and N-ras (IC50: 1.9/5.2/2.8 nM).
T4619	ML098	ML-098 is an activator of the GTP-binding protein Rab7 (EC50: 77.6 nM).
T5379	Antineoplaston A10	Antineoplaston A10 is a naturally occurring substance and the first antineoplaston in the human body to be chemically identified. It displayed anti-proliferative action inhibiting
T7131	Antineoplaston A10	Antineoplaston A 10 is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.
T7328	AMG-510	AMG-510 is a potent KRAS G12C covalent inhibitor, treatment with AMG 510 led to the regression of KRASG12C tumours and improved the anti-tumour efficacy of chemotherapy and targete
T7326	6H05	6H05 is a selective, and allosteric oncogenic mutant K-Ras(G12C) inhibitor.
T7609	ARS-1620	ARS-1620 is a covalent inhibitor of K-RASG12C.
T7558	CID-1067700	CID-1067700 is one of the first identified competitive inhibitors of nucleotide binding by Ras-related GTPases（Rab7 with a Ki of 13 nM).
T8006	Oncrasin 1	Oncrasin 1 is a potent inhibitor of anticancer that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations
T8369	MRTX849	MRTX849 is a potent, selective, and covalent KRASG12C inhibitor with potential antineoplastic activity.selectively modifies mutant cysteine 12 in GDP-bound KRASG12C, and inhibits K
T13844	PROTAC K-Ras Degrader-1	PROTAC K-Ras Degrader-1 is potent degrader of K-Ras based PROTAC.
T10375	ARS-1323	ARS-1323 (the racemate of ARS-1620) is a mutant K-ras G12C inhibitor extracted from patent WO 2015054572 A1.
T10374	ARS-1323-alkyne	ARS-1323-alkyne is a switch-II pocket (S-IIP) inhibitor and a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.
T10376	ARS-1630	ARS-1630 is a mutant K-ras G12C inhibitor extracted from patent WO 2015054572 A1. It is a less active enantiomer of ARS-1620.
T12979	BI-3406	BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 of 6 nM),with anticancer activity.
T10533	BI-2852	BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) with nanomolar affinity. BI-2852 is leading to inhibition of downstream signaling and an antiproliferative eff
T11744	KB-5246	KB-5246, displays antibacterial activities.is a tetracyclic quinolone.
T16023	MC 976	MC 976 is a derivative of Vitamin D3.
T11767	KRAS G12C inhibitor 13	KRAS G12C inhibitor 13 is a KRAS G12C inhibitor .
T11768	KRAS G12C inhibitor 14	KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor .
T11769	KRAS G12C inhibitor 15	KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor .
T11770	KRAS G12C inhibitor 16	KRAS G12C inhibitor 16 is a potent KRAS G12C inhibitor.
T11771	KRAS G12C inhibitor 17	KRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor.
T11773	KRAS inhibitor-6	KRAS inhibitor-6 is a potent KRAS G12C inhibitor.
T11774	KRAS inhibitor-7	KRAS inhibitor-7 is a potent KRAS G12C inhibitor.
T11775	KRAS inhibitor-8	KRAS inhibitor-8 is a potent KRAS G12C inhibitor.
T11776	KRas G12C inhibitor 1	KRas G12C inhibitor 1 is a compound that inhibits KRas G12C.
T11777	KRas G12C inhibitor 2	KRas G12C inhibitor 2 is a compound that inhibits KRas G12C.
T11778	KRas G12C inhibitor 3	KRas G12C inhibitor 3 is a compound that inhibits KRas G12C.
T11779	KRas G12C inhibitor 4	KRas G12C inhibitor 4 is a compound that inhibits KRas G12C.
T11780	KRAS G12C inhibitor 5	KRAS G12C inhibitor 5 is a KRas G12C inhibitor.
T8684	AMG-510	AMG-510 is a selective and orally bioavailable KRAS G12C covalent inhibitor.