T9407 |
Rasarfin |
Rasarfin inhibits Ras and ARF6.
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T13844 |
PROTAC K-Ras Degrader-1 |
PROTAC K-Ras Degrader-1 is potent degrader of K-Ras based PROTAC.
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T16023 |
MC 976 |
MC 976 is a derivative of Vitamin D3.
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T16021 |
MBQ-167 |
MBQ-167 is a dual inhibitor of Rac/Cdc42 (IC50s: 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively).
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T11744 |
KB-5246 |
KB-5246, displays antibacterial activities.is a tetracyclic quinolone.
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T11738 |
K-Ras G12C-IN-4 |
K-Ras G12C-IN-4 is a potent co-valent Inhibitor of KRAS G12C..
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T10533 |
BI-2852 |
BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) with nanomolar affinity. BI-2852 is leading to inhibition of downstream signaling and an an...
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T12979 |
BI-3406 |
BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.
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T10376 |
ARS-1630 |
ARS-1630 is a mutant K-ras G12C inhibitor extracted from patent WO 2015054572 A1. It is a less active enantiomer of ARS-1620.
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T10374 |
ARS-1323-alkyne |
ARS-1323-alkyne is a switch-II pocket (S-IIP) inhibitor and a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.
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T10375 |
ARS-1323 |
ARS-1323 (the racemate of ARS-1620) is a mutant K-ras G12C inhibitor extracted from patent WO 2015054572 A1.
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T8369 |
MRTX849 |
MRTX849 is a potent, selective and covalent KRASG12C inhibitor with potential antineoplastic activity. It selectively modifies mutant cysteine 12 in GDP-bound KR...
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T11767 |
KRAS G12C inhibitor 13 |
KRAS G12C inhibitor 13 is a KRAS G12C inhibitor .
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T8006 |
Oncrasin 1 |
Oncrasin 1 is a potent inhibitor of anticancer that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations
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T7558 |
CID-1067700 |
CID-1067700 is one of the first identified competitive inhibitors of nucleotide binding by Ras-related GTPases(Rab7 with a Ki of 13 nM).
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T7609 |
ARS-1620 |
ARS-1620 is a covalent inhibitor of K-RASG12C.
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T7326 |
6H05 TFA |
6H05 TFA is a selective, and allosteric oncogenic mutant K-Ras(G12C) inhibitor.
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T7328 |
Sotorasib |
Sotorasib is a potent KRAS G12C covalent inhibitor, treatment with AMG 510 led to the regression of KRASG12C tumours and improved the anti-tumour efficacy of ch...
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T7131 |
Antineoplaston A10 |
Antineoplaston A 10 is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.
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T5469 |
K-Ras-IN-1 |
K-Ras-IN-1 is a K-Ras inhibitor.
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T5379 |
Antineoplaston A10 |
Antineoplaston A10 is a naturally occurring substance and the first antineoplaston in the human body to be chemically identified. It displayed anti-proliferative...
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T4619 |
ML098 |
ML-098 is an activator of the GTP-binding protein Rab7 (EC50: 77.6 nM).
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T6302 |
Lonafarnib |
Lonafarnib is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B, and N-ras (IC50: 1.9/5.2/2.8 nM).
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T16143 |
MRTX-1257 |
MRTX-1257 is a selective, irreversible, and covalent inhibitor of KRAS G12C. It has an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells. MRTX...
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T11768 |
KRAS G12C inhibitor 14 |
KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor .
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T9303 |
MRTX1133 |
MRTX1133 is a potent, selective, noncovalent KRASG12D inhibitor. It has picomolar binding affinity, single-digit nanomolar activity in cellular assays. In additi...
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T22258 |
AMG-510 racemate |
AMG-510 racemate is a racemic of AMG-510 which is a potent inhibitor of KRAS G12C covalent, and leading to potential antineoplastic activity.
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T9184L |
Compound 3344 hydrochloride |
Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions,with an affnity of 126nm.
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T9198 |
SCH54292 |
SCH-54292 is a GDP exchange inhibitor.
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T9184 |
Compound 3344 |
3344 is an inhibitor of KRAS-effector interactions,with an affnity of 126nm.
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T8870 |
1-(4-methansulfinylphenyl)ethanone |
The compound inhibits Ras function and therefore inhibits the abnormal growth of cells.
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T8843 |
APS6-45 |
APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.
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T8756 |
KRAS inhibitor-9 |
KRAS inhibitor-9 is a potent KRAS inhibitor with Kd of 92 μM that blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 causes...
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T8756 |
KRAS inhibitor-9 |
KRAS inhibitor-9 is a potent KRAS inhibitor with Kd of 92 μM that blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 causes...
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T8375 |
ML-210 |
ML-210 is a selective RAS and covalent glutathione peroxidase 4 (GPX4) inhibitor(GPX4, EC50 : 30 nM), with anti-cancer activity
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T8684 |
AMG-510 |
AMG-510 is a selective and orally bioavailable KRAS G12C covalent inhibitor.
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T22249 |
1588-A4 |
1588-A4 is an intermediate of ARS-1620 which is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.
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T11769 |
KRAS G12C inhibitor 15 |
KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor .
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T11780 |
KRAS G12C inhibitor 5 |
KRAS G12C inhibitor 5 is a KRas G12C inhibitor.
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T11779 |
KRas G12C inhibitor 4 |
KRas G12C inhibitor 4 is a compound that inhibits KRas G12C.
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T11778 |
KRas G12C inhibitor 3 |
KRas G12C inhibitor 3 is a compound that inhibits KRas G12C.
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T11777 |
KRas G12C inhibitor 2 |
KRas G12C inhibitor 2 is a compound that inhibits KRas G12C.
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T11776 |
KRas G12C inhibitor 1 |
KRas G12C inhibitor 1 is a compound that inhibits KRas G12C.
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T11775 |
KRAS inhibitor-8 |
KRAS inhibitor-8 is a potent KRAS G12C inhibitor.
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T11774 |
KRAS inhibitor-7 |
KRAS inhibitor-7 is a potent KRAS G12C inhibitor.
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T11773 |
KRAS inhibitor-6 |
KRAS inhibitor-6 is a potent KRAS G12C inhibitor.
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T11771 |
KRAS G12C inhibitor 17 |
KRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor.
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T11770 |
KRAS G12C inhibitor 16 |
KRAS G12C inhibitor 16 is a potent KRAS G12C inhibitor.
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T6163 |
Salirasib |
Salirasib(Ki=2.6 μM), an effective competitive prenylated protein methyltransferase (PPMTase) inhibitor, inhibits Ras methylation with potential antineoplastic ...
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