Ras

Ras is a family of related proteins which is expressed in all animal cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells (cellular signal transduction). Ras is the prototypical member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse cell behaviours.

产品编号	产品名称
T9407	Rasarfin	Rasarfin inhibits Ras and ARF6.
T13844	PROTAC K-Ras Degrader-1	PROTAC K-Ras Degrader-1 is potent degrader of K-Ras based PROTAC.
T16023	MC 976	MC 976 is a derivative of Vitamin D3.
T16021	MBQ-167	MBQ-167 is a dual inhibitor of Rac/Cdc42 (IC50s: 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively).
T11744	KB-5246	KB-5246, displays antibacterial activities.is a tetracyclic quinolone.
T11738	K-Ras G12C-IN-4	K-Ras G12C-IN-4 is a potent co-valent Inhibitor of KRAS G12C..
T10533	BI-2852	BI-2852 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) with nanomolar affinity. BI-2852 is leading to inhibition of downstream signaling and an an...
T12979	BI-3406	BI-3406 is an orally active, highly potent and selective between KRAS and Son of Sevenless 1 (SOS1) interaction inhibitor(IC50 : 6 nM),with anticancer activity.
T10376	ARS-1630	ARS-1630 is a mutant K-ras G12C inhibitor extracted from patent WO 2015054572 A1. It is a less active enantiomer of ARS-1620.
T10374	ARS-1323-alkyne	ARS-1323-alkyne is a switch-II pocket (S-IIP) inhibitor and a conformational specific chemical reporter of KRASG12C nucleotide state in living cells.
T10375	ARS-1323	ARS-1323 (the racemate of ARS-1620) is a mutant K-ras G12C inhibitor extracted from patent WO 2015054572 A1.
T8369	MRTX849	MRTX849 is a potent, selective and covalent KRASG12C inhibitor with potential antineoplastic activity. It selectively modifies mutant cysteine 12 in GDP-bound KR...
T11767	KRAS G12C inhibitor 13	KRAS G12C inhibitor 13 is a KRAS G12C inhibitor .
T8006	Oncrasin 1	Oncrasin 1 is a potent inhibitor of anticancer that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations
T7558	CID-1067700	CID-1067700 is one of the first identified competitive inhibitors of nucleotide binding by Ras-related GTPases（Rab7 with a Ki of 13 nM).
T7609	ARS-1620	ARS-1620 is a covalent inhibitor of K-RASG12C.
T7326	6H05 TFA	6H05 TFA is a selective, and allosteric oncogenic mutant K-Ras(G12C) inhibitor.
T7328	Sotorasib	Sotorasib is a potent KRAS G12C covalent inhibitor, treatment with AMG 510 led to the regression of KRASG12C tumours and improved the anti-tumour efficacy of ch...
T7131	Antineoplaston A10	Antineoplaston A 10 is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.
T5469	K-Ras-IN-1	K-Ras-IN-1 is a K-Ras inhibitor.
T5379	Antineoplaston A10	Antineoplaston A10 is a naturally occurring substance and the first antineoplaston in the human body to be chemically identified. It displayed anti-proliferative...
T4619	ML098	ML-098 is an activator of the GTP-binding protein Rab7 (EC50: 77.6 nM).
T6302	Lonafarnib	Lonafarnib is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B, and N-ras (IC50: 1.9/5.2/2.8 nM).
T16143	MRTX-1257	MRTX-1257 is a selective, irreversible, and covalent inhibitor of KRAS G12C. It has an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells. MRTX...
T11768	KRAS G12C inhibitor 14	KRAS G12C inhibitor 14 is a potent KRAS G12C inhibitor .
T9303	MRTX1133	MRTX1133 is a potent, selective, noncovalent KRASG12D inhibitor. It has picomolar binding affinity, single-digit nanomolar activity in cellular assays. In additi...
T22258	AMG-510 racemate	AMG-510 racemate is a racemic of AMG-510 which is a potent inhibitor of KRAS G12C covalent, and leading to potential antineoplastic activity.
T9184L	Compound 3344 hydrochloride	Compound 3344 hydrochloride is an inhibitor of KRAS-effector interactions，with an affnity of 126nm.
T9198	SCH54292	SCH-54292 is a GDP exchange inhibitor.
T9184	Compound 3344	3344 is an inhibitor of KRAS-effector interactions，with an affnity of 126nm.
T8870	1-(4-methansulfinylphenyl)ethanone	The compound inhibits Ras function and therefore inhibits the abnormal growth of cells.
T8843	APS6-45	APS6-45 inhibits RAS/MAPK signaling and exhibits anti-tumor activity.
T8756	KRAS inhibitor-9	KRAS inhibitor-9 is a potent KRAS inhibitor with Kd of 92 μM that blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 causes...
T8756	KRAS inhibitor-9	KRAS inhibitor-9 is a potent KRAS inhibitor with Kd of 92 μM that blocks the formation of GTP-KRAS and downstream activation of KRAS. KRAS inhibitor-9 causes...
T8375	ML-210	ML-210 is a selective RAS and covalent glutathione peroxidase 4 (GPX4) inhibitor(GPX4, EC50 : 30 nM), with anti-cancer activity
T8684	AMG-510	AMG-510 is a selective and orally bioavailable KRAS G12C covalent inhibitor.
T22249	1588-A4	1588-A4 is an intermediate of ARS-1620 which is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.
T11769	KRAS G12C inhibitor 15	KRAS G12C inhibitor 15 is a potent KRAS G12C inhibitor .
T11780	KRAS G12C inhibitor 5	KRAS G12C inhibitor 5 is a KRas G12C inhibitor.
T11779	KRas G12C inhibitor 4	KRas G12C inhibitor 4 is a compound that inhibits KRas G12C.
T11778	KRas G12C inhibitor 3	KRas G12C inhibitor 3 is a compound that inhibits KRas G12C.
T11777	KRas G12C inhibitor 2	KRas G12C inhibitor 2 is a compound that inhibits KRas G12C.
T11776	KRas G12C inhibitor 1	KRas G12C inhibitor 1 is a compound that inhibits KRas G12C.
T11775	KRAS inhibitor-8	KRAS inhibitor-8 is a potent KRAS G12C inhibitor.
T11774	KRAS inhibitor-7	KRAS inhibitor-7 is a potent KRAS G12C inhibitor.
T11773	KRAS inhibitor-6	KRAS inhibitor-6 is a potent KRAS G12C inhibitor.
T11771	KRAS G12C inhibitor 17	KRAS G12C inhibitor 17 is a potent KRAS G12C inhibitor.
T11770	KRAS G12C inhibitor 16	KRAS G12C inhibitor 16 is a potent KRAS G12C inhibitor.
T6163	Salirasib	Salirasib(Ki=2.6 μM), an effective competitive prenylated protein methyltransferase (PPMTase) inhibitor, inhibits Ras methylation with potential antineoplastic ...