激酶抑制剂库 | 陶术生物

激酶抑制剂库

Kinase Inhibitor Library

产品编号： L1600

在生物化学中，激酶是一类从高能供体分子（如 ATP）转移磷酸基团到特定靶分子的酶；这一过程谓之磷酸化。比较常见的激酶族群是蛋白激酶，蛋白激酶作用于特定的蛋白质，使其磷酸化而改变其活性。这些激酶在细胞的信号转导及其复杂的生命活动中起了广泛的作用。其他不同的激酶作用于小分子物质（脂质、糖、氨基酸、核苷等），或者为了发出信号，或者使它们为代谢中各种生化反应作好准备。

TargetMol 激酶抑制剂库含有 2720 种靶向激酶的小分子化合物，包括激酶抑制剂、激酶调节剂，这些激酶包括：Insulin/IGF Receptors、PI 3-Kinase、CaM Kinase II、JAK、PKA、CDK、JNK、PKC、CKI II、MAPK、RAF、EGFR、MEK、SAPK、GSK、MLCK、Src-family、IKK、PDGFR、VEGFR 等。该库是化学基因组学和药理学研究的理想工具。

陶术生物的所有产品和服务仅用于科学研究，我们不为任何个人用途提供产品和服务。

产品规格

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陶术生物化合物库目录(28.1MB)

库化合物信息

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产品描述

2720种激酶抑制剂/调节剂的独特集合，用于特定靶向激酶，可用于高通量筛选和高内涵筛选；
其中一些激酶抑制剂/调节剂已得到FDA批准上市；
大部分为ATP竞争性抑制剂；
详细的说明书，化合物结构、靶点信息、IC50值、活性描述等；
NMR和HPLC检测技术保证产品高纯度；
所有化合物现货供应。

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化合物库组成

Apoptosis (388)

Autophagy (292)

CDK (231)

PI3K (202)

EGFR (190)

VEGFR (164)

JAK (111)

mTOR (111)

Akt (103)

p38 MAPK (102)

ERK (101)

FLT (101)

Src (100)

PDGFR (94)

PKC (87)

AMPK (84)

FGFR (83)

GSK-3 (82)

Raf (81)

c-Kit (75)

Ras (73)

NF-κB (71)

c-Met/HGFR (69)

Bcr-Abl (67)

Aurora Kinase (57)

ALK (57)

BTK (56)

MAPK (56)

JNK (52)

MEK (49)

Tyrosine Kinases (48)

ROCK (47)

Casein Kinase (47)

PKA (46)

Antibacterial (41)

Endogenous Metabolite (41)

Serine/threonin kinase (40)

IGF-1R (40)

DNA-PK (38)

c-RET (38)

TAM Receptor (37)

Epigenetic Reader Domain (36)

TGF-beta/Smad (36)

IκB/IKK (35)

CaMK (34)

Trk receptor (34)

S6 Kinase (33)

Glucosidase (32)

FAK (32)

RIP kinase (31)

Glucokinase (30)

PLK (30)

HER (30)

STAT (29)

ATM/ATR (28)

c-Fms (28)

TNF (28)

Parasite (27)

Syk (27)

Pim (25)

Chk (25)

PERK (24)

ROR (23)

IRAK (22)

DYRK (21)

Caspase (21)

COX (20)

LRRK2 (20)

Mitophagy (19)

PDK (19)

Antibiotic (19)

HIV Protease (18)

Wnt/beta-catenin (18)

PAK (18)

Influenza Virus (18)

Rho (16)

IRE1 (16)

Reactive Oxygen Species (16)

DNA/RNA Synthesis (16)

Tyrosinase (16)

Calcium Channel (15)

IL Receptor (15)

PI4K (15)

Ferroptosis (14)

Phosphatase (14)

ROS Kinase (14)

Ephrin Receptor (13)

Antifungal (12)

PPAR (12)

BCL (12)

5-HT Receptor (12)

P450 (12)

AChR (12)

Adrenergic Receptor (11)

CSF-1R (11)

MMP (11)

Potassium Channel (11)

S1P Receptor (11)

PDE (10)

GRK (10)

ROS (10)

MNK (10)

Discoidin Domain Receptor (DDR) (10)

MLK (10)

Dehydrogenase (9)

Adenosine Receptor (9)

Serine Protease (9)

HSV (9)

SGK (9)

Microtubule Associated (9)

PKM (9)

NO Synthase (9)

Kinesin (9)

PARP (8)

Wee1 (8)

Antiviral (8)

SARS-CoV (8)

Beta Amyloid (8)

Sodium Channel (8)

Tie-2 (7)

Virus Protease (7)

SIK (7)

AAK1 (AP2 associated kinase 1) (7)

Mitochondrial Metabolism (7)

Lipoxygenase (7)

Interleukin (7)

HDAC (7)

Histamine Receptor (6)

TOPK (6)

LIM Kinase (6)

Topoisomerase (6)

Drug Metabolite (6)

AChE (6)

P-gp (6)

Nrf2 (6)

MELK (6)

Dopamine Receptor (5)

Histone Methyltransferase (5)

HCV Protease (5)

Integrin (5)

Antioxidant (5)

PYK2 (5)

LDL (5)

ACK (5)

TLR (5)

transporter (5)

ASK (5)

Hippo pathway (5)

Ligand for E3 Ligase (5)

Carbonic Anhydrase (4)

Estrogen/progestogen Receptor (4)

LPL Receptor (4)

GTPase (4)

TRP/TRPV Channel (4)

Myosin (4)

GluR (4)

Carboxypeptidase (4)

DAPK (4)

ATPase (3)

NOS (3)

Transferase (3)

Ligands for Target Protein for PROTAC (3)

YAP (3)

BACE (3)

IFNAR (3)

Glutathione Peroxidase (3)

HBV (3)

Estrogen Receptor/ERR (3)

Hck (3)

MAO (3)

Aryl Hydrocarbon Receptor (3)

E1/E2/E3 Enzyme (3)

Haspin Kinase (3)

Antifection (3)

Hexokinase (3)

DNA Alkylation (3)

Indoleamine 2,3-Dioxygenase (IDO) (3)

HSP (3)

Prostaglandin Receptor (3)

Sirtuin (3)

PAI-1 (3)

cholecystokinin (3)

HIF/HIF Prolyl-Hydroxylase (3)

p53 (3)

Chloride channel (2)

Proton pump (2)

PROTACs (2)

NADPH (2)

RAAS (2)

Serotonin Transporter (2)

Nucleoside Antimetabolite/Analog (2)

FXR (2)

Gamma-secretase (2)

PTEN (2)

cAMP (2)

DUB (2)

BCRP (2)

Beta-Secretase (2)

Histone Acetyltransferase (2)

Reverse Transcriptase (2)

CRISPR/Cas9 (2)

Phospholipase (2)

HIF (2)

Cannabinoid Receptor (2)

Anti-infection (2)

NADPH-oxidase (2)

Proteasome (1)

NPC1L1 (1)

DHFR (1)

MyD88 (1)

Arrestin (1)

RAR/RXR (1)

Histone Demethylase (1)

CETP (1)

Necroptosis (1)

gp120/CD4 (1)

Melatonin Receptor (1)

MRP (1)

Antifolate (1)

cell cycle arrest (1)

Liver X Receptor (1)

NAMPT (1)

Stemness kinase (1)

iGluR (1)

Phosphorylase (1)

P2X Receptor (1)

NMDAR (1)

Monoamine Transporter (1)

Opioid Receptor (1)

PROTAC Linker (1)

Fatty Acid Synthase (1)

Bombesin Receptor (1)

Hedgehog/Smoothened (1)

FAAH (1)

PAD (1)

Thrombopoietin Receptor (1)

Norepinephrine (1)

DNA (1)

Androgen Receptor (1)

ATP Citrate Lyase (1)

Lipid (1)

PGE Synthase (1)

Acyltransferase (1)

Porcupine (1)

STING (1)

Decarboxylase (1)

cGAS (1)

RSV (1)

GPX (1)

Retinoid Receptor (1)

Protease (1)

Aromatase (1)

GPR (1)

GABA Receptor (1)

Hydroxylase (1)

RXFP receptor (1)

Fer/FerT kinase (1)

Gap Junction Protein (1)

BMI-1 (1)

Sigma receptor (1)

Protease-activated Receptor (1)

p97 (1)

AhR (1)

PD-1/PD-L1 (1)

化合物库信息示例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty

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