目录号 | 产品详情 | 靶点 | |
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T0670 | Amino Acids and Derivatives Endogenous Metabolite NO Synthase | ||
L-Arginine hydrochloride 为合成一氧化氮的氮供体,是血管扩张剂。 | |||
T6888 | Guanylate cyclase Microtubule Associated NO Synthase Parasite Monoamine Oxidase | ||
Methylene Blue (Tetramethylthionine chloride) 是鸟苷酸环化酶,是单胺氧化酶 A 和 NO 合酶抑制剂。它有抗伤害感受、抗疟疾、抗抑郁和抗焦虑作用,可研究高铁血红蛋白血症、神经退行性疾病和异环磷酰胺引起的脑病。它是血管加压剂,用作色素内窥镜检查中的染料。 | |||
T0006 | Guanylate cyclase Microtubule Associated NO Synthase Parasite Monoamine Oxidase | ||
Methylene Blue trihydrate (Basic blue 9) 是鸟苷酸环化酶,单胺氧化酶 A 和 NO 合酶抑制剂。它是血管加压药,在医疗中通常用作染料。它具有抗伤害感受,抗疟疾,抗抑郁和抗焦虑作用,可用于高铁血红蛋白血症,神经退行性疾病和异环磷酰胺引起的脑病的研究。 | |||
T3211 | Others PKC | ||
Midostaurin (PKC412) 是一种多靶点蛋白激酶抑制剂,有抗肿瘤活性,对 PKCα/β/γ、Syk、Flk-1、Akt、PKA、c-Kit、c-Fgr、c-Src、FLT3、PDFRβ和VEGFR1/2的IC50值范围为 22 到500 nM 之间。 | |||
T6570 | NOS NO Synthase | ||
L-NAME hydrochloride (L-NAME HCl) 是NOS 抑制剂(IC50:70 μM)。 | |||
T0358 | NOS NO Synthase | ||
Aminoguanidine hydrochloride (Hydrazinecarboximidamide) 是二胺氧化酶抑制剂,也是一氧化氮合酶抑制剂,可用于糖尿病肾病的研究。 | |||
TN1102 | Others NO Synthase | ||
Physalin L 抑制巨噬细胞中 LPS 诱导的 NO 生成,平均抑制率是 70.97%。它具有抗炎作用。 | |||
T9537 | Others | ||
N'-Nitro-D-arginine (N'-Nitro-D-arginine) 是一种砌块。 | |||
T7206 | NOS NO Synthase | ||
2-Iminobiotin (Guanidinobiotin) 是一种生物素 (维生素 H 或 B7) 类似物。它是一种可逆的 NO 合酶抑制剂,能够作用于小鼠 iNOS(Ki:21.8 μM)及大鼠 n-cNOS(Ki:37.5 μM)。它和低温环境均可以保护人类神经细胞,使其免受缺氧诱导的细胞损伤。 | |||
T1244 | Adrenergic Receptor | ||
Celiprolol hydrochloride (Selectrol) 是一种选择性肾上腺素受体调节剂,是一种选择性的和具有口服活性的β1肾上腺素受体拮抗剂,具有部分β2激动剂活性,具有降压和抗心绞痛的作用。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPH-01733 | DDAH2 Protein, Human, Recombinant (GST & His) | Human | E. coli | ||
Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. DDAH2 Protein, Human, Recombinant (GST & His) is expressed in E. coli expression system with N-6xHis-GST tag. The predicted molecular weight is 61.2 kDa and the accession number is O95865.
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TMPH-01732 | DDAH1 Protein, Human, Recombinant (His & Myc) | Human | E. coli | ||
Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. DDAH1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 38.4 kDa and the accession number is O94760.
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TMPY-03172 | Argininosuccinate lyase Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells | ||
The recycling of citrulline by argininosuccinate synthase 1 (ASS1) and argininosuccinate lyase (ASL) is crucial to maintain arginine availability and nitric oxide (NO) production. Nitric oxide (NO) plays an established role in numerous physiological and pathological processes, but the specific cellular sources of NO in disease pathogenesis remain unclear, preventing the implementation of NO-related therapy. Argininosuccinate lyase (ASL) is the only enzyme able to produce arginine, the substrate for NO generation by nitric oxide synthase (NOS) isoforms. Induction of endogenous NO production by enterocytes with supplements that upregulate ASL expression and complement its substrates results in improved epithelial integrity and alleviation of colitis and of inflammation-associated colon cancer.
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TMPH-02526 | Arginase-2/ARG2 Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli | ||
May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated CD4(+) and CD8(+) T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May contribute to the immune evasion of H.pylori by restricting M1 macrophage activation and polyamine metabolism. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction. Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling. Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity.
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TMPH-02524 | Arginase-1/ARG1 Protein, Mouse, Recombinant (His) | Mouse | P. pastoris (Yeast) | ||
Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys.; Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion. In group 2 innate lymphoid cells (ILC2s) promotes acute type 2 inflammation in the lung and is involved in optimal ILC2 proliferation but not survival. Plays a role in the immune response of alternatively activated or M2 macrophages in processes such as wound healing and tissue regeneration, immune defense against multicellular pathogens and parasites, and immune suppression and allergic inflammation; the regulatory outcome seems to be organ specific. In tumor-infiltrating dendritic cells (DCs) and myeloid-derived suppressor cells (MDSCs) plays a role in suppression of T cell-mediated antitumor immunity.
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