目录号 | 产品详情 | 靶点 | |
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T63304 | |||
Topoisomerase II inhibitor 9 是 Topo II 抑制剂 (IC50: 0.97 μM),也是 DNA 嵌入剂 (IC50: 43.51 μM),能够在 G2/M 期阻滞 Hep G‐2 细胞周期,诱导细胞凋亡 (apoptosis)。 | |||
T1523 | Topoisomerase | ||
Teniposide (VM26) 是鬼臼毒素的半合成衍生物,具有抗肿瘤活性,通过与拓扑异构酶 II 和 DNA 形成复合物来抑制 DNA 合成。 | |||
T11249L | Topoisomerase | ||
Dxd (OQM5SD32BQ) 是一种有效的DNA 拓扑异构酶 I 抑制剂,IC50值为 0.31 μM,用作HER2靶向ADC 的偶联药物。 | |||
T5784 | Topoisomerase Autophagy | ||
Topotecan (NSC-609669) 是一种拓扑异构酶 I 抑制剂,通过抑制 DNA 拓扑异构酶起抗肿瘤作用,可用于治疗卵巢癌。 | |||
T1206 | Potassium Channel Topoisomerase Autophagy | ||
Amsacrine (AMSA) 是一种抗肿瘤剂,可以嵌入到肿瘤细胞的 DNA 中。它还表达拓扑异构酶抑制剂活性,特异性抑制拓扑异构酶 II。 | |||
T5S0761 | Apoptosis ERK FAK p38 MAPK NF-κB Topoisomerase STAT Parasite | ||
Nitidine chloride 是从Zanthoxylum nitidum (Roxb) DC 中分离得到的,具有抗疟疾活性。它通过多个靶点通路,起抗癌作用,抑制STAT3、DNA 拓扑异构酶1和2A、ERK 和c-Src/FAK 相关信号通路。它通过MAPK 和NF-kB 途径抑制Lps 诱导的炎性细胞因子的产生。 | |||
T4S0797 | Reactive Oxygen Species Topoisomerase Endogenous Metabolite Antibacterial Antibiotic Autophagy | ||
Berberine (Umbellatine) 是从中草药黄连中分离出来的一种生物碱抗生素。它诱导活性氧生成并抑制 DNA 拓扑异构酶,具有抗肿瘤特性。 | |||
T3S1957 | Topoisomerase | ||
9-amino-CPT (Aminocamptothecin) 是一种拓扑异构酶I 的抑制剂,具有抗肿瘤活性。 | |||
T61017 | |||
Topoisomerase II inhibitor 6 (Compound 5) 是色胺酮的衍生物。它是一种有效的拓扑异构酶的选择性抑制剂。Topoisomerase II inhibitor 6 在 G2 期阻断 CCRF-CEM 的细胞周期并诱导 DNA 双链断裂。Topoisomerase II inhibitor 6 对不同的肿瘤细胞系具有抗增殖活性,在癌症疾病研究中具有潜力。 | |||
T64047 | |||
Topoisomerase II inhibitor 10 是拓扑异构酶II (topoisomerase II) 的有效抑制剂 (IC50: 7.45 μM)。Topoisomerase II inhibitor 10 对 HepG-2、MCF-7 和 HCT-116 细胞表现出良好的抗增殖作用。Topoisomerase II inhibitor 10 能够将 HepG-2 细胞的细胞周期阻滞在 G2-M 期,并诱导其凋亡 (apoptosis)。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-01776 | Carboxylesterase 2/CES2 Protein, Human, Recombinant (His) | Human | HEK293 | ||
Carboxylesterase 2 (CES2) is a member of the carboxylesterase family and belongs to the multigene family. Carboxylesterase 2 is responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and beroin. It also serves to hydrolyze long-chain fatty acid esters and thioesters. It is speculated that carboxylesterases may play a role in lipid metabolism and the blood-brain barrier system and together with isform 1, are a serine esterase involved in both drug metabolism and activation. Human carboxylesterase 2 is commonly expressed in tumor tissues and irinotecan, a topoisomerase I inhibitor commonly used in the treatment of many solid tumors.
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TMPH-00610 | gyrA Protein, E. coli, Recombinant (His) | E. coli | E. coli | ||
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to maintain chromosomes in an underwound state. This makes better substrates for topoisomerase IV (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli. Gyrase catalyzes the interconversion of other topological isomers of dsDNA rings, including catenanes. Relaxes negatively supercoiled DNA in an ATP-independent manner. E.coli gyrase has higher supercoiling activity than many other bacterial gyrases; at comparable concentrations E.coli gyrase introduces more supercoils faster than M.tuberculosis gyrase, while M.tuberculosis gyrase has higher decatenation than supercoiling activity compared to E.coli. E.coli makes 15% more negative supercoils in pBR322 plasmid DNA than S.typhimurium; the S.typhimurium GyrB subunit is toxic in E.coli, while the E.coli copy can be expressed in S.typhimurium even though the 2 subunits have 777/804 residues identical. The enzymatic differences between E.coli gyrase and topoisomerase IV are largely due to the GyrA C-terminal domain (approximately residues 524-841) and specifically the GyrA-box.; Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
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TMPH-03470 | GyrB Protein, Salmonella typhi, Recombinant (His & Myc) | Salmonella typhi | E. coli | ||
A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
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TMPY-01690 | Carboxylesterase 2/CES2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 | ||
Carboxylesterase 2 (CES2) is a member of the carboxylesterase family and belongs to the multigene family. Carboxylesterase 2 is responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and beroin. It also serves to hydrolyze long-chain fatty acid esters and thioesters. It is speculated that carboxylesterases may play a role in lipid metabolism and the blood-brain barrier system and together with isform 1, are a serine esterase involved in both drug metabolism and activation. Human carboxylesterase 2 is commonly expressed in tumor tissues and irinotecan, a topoisomerase I inhibitor commonly used in the treatment of many solid tumors.
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