目录号 | 产品详情 | 靶点 | |
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T69622 | |||
Ritivixibat为回肠胆汁酸转运蛋白(IBAT)抑制剂,同时也是胆汁酸调节剂,主要适用于心血管疾病、脂肪酸代谢及葡萄糖利用障碍、胃肠道和肝脏疾病的研究。 | |||
TMIH-0013 | |||
(S)-Empagliflozin-d4 是 (S)-Empagliflozin 的氘代化合物。(S)-Empagliflozin 的 CAS 号为 864070-44-0。Empagliflozin 是有效的、选择性的钠葡萄糖协同转运蛋白-2 (SGLT-2) 抑制剂,对人 SGLT-2 的IC50为 3.1 nM。 | |||
T70903 | |||
KRH102053 is a HIF-1alpha inhibitor. KRH102053 decreased the protein level of HIF-1alpha and the mRNA levels of HIF-regulated downstream target genes, such as vascular endothelial growth factor, aldolase A, enolase 1 and monocarboxylate transporter 4. Consistent with these results, KRH102053 also inhibited the rates of HIF-related migration and invasion of HOS cells as well as the degree of tube formation in human umbilical vein endothelium cells. | |||
T36142 | |||
10-PAHSA is a newly identified endogenous lipid that belongs to a collection of branched fatty acid esters of hydroxy fatty acids (FAHFAs). It is a FAHFA in which palmitic acid is esterified to 10-hydroxy stearic acid. Among the FAHFA family members, PAHSAs are the most abundant in the adipose tissue of glucose tolerant AG4OX mice, which overexpress the Glut4 glucose transporter specifically in adipose tissue. As other FAHFAs improve glucose tolerance, stimulate insulin secretion, and have anti-inflammatory effects, 10-PAHSA may be a bioactive lipid with roles in metabolic syndrome and inflammation. | |||
T70914 | |||
GBR-12935 is a potent and selective dopamine reuptake inhibitor. It was originally developed in its 3H radiolabelled form for the purpose of mapping the distribution of dopaminergic neurons in the brain by selective labelling of dopamine transporter proteins. This has led to potential clinical uses in the diagnosis of Parkinson's disease, although selective radioligands such as Ioflupane (¹²³I) are now available for this application. GBR-12935 is now widely used in animal research into Parkinson's disease and the dopamine pathways in the brain. (Source: http://en.wikipedia.org/wiki/GBR-12935). | |||
T73857 | |||
Mesembrine ((+)-Mesembrine) 一种主要的生物碱,具有芳基八氢吲哚骨架。Mesembrine 是一种5-HT 转运蛋白抑制剂,Ki 为 1.4 nM。Mesembrine 还抑制磷酸二酯酶 4B (PDE4B),IC50为 7.8 μM。 | |||
T78076 | Others | ||
PBR28是一种TSPO调节剂,适用于肺动脉高压(PAH)预防研究。通过增加放射性标记的PBR28能够示踪18KDa转运蛋白(TSPO),在脑正电子发射断层扫描(PET)成像中具有关键作用。 | |||
T37118 | |||
ADP-Glucose (ADPG) is an immediate precursor used in the biosynthesis, by glucose addition, of storage polysaccharides in plants, green algae, and cyanobacteria, as well as structural polysaccharides in certain bacteria.[1],[2] It is used by amylose synthases or starch synthases in plastids in the production of amylose, amylopectins, starch, and other polysaccharides. ADPG is normally generated within plastids, although it can be biosynthesized in the cytoplasm of certain grasses and imported into plastids by a membrane-bound transporter.[3] | |||
T72515 | |||
Elobixibat hydrate是一有效胆汁酸转运体(IBAT)抑制剂,对人类IBAT、小鼠IBAT及犬类IBAT的IC50值分别为0.53±0.17 nM、0.13±0.03 nM和5.8±1.6 nM。适用于研究老年慢性功能性便秘(CIC)。 | |||
TMIH-0209 | |||
Elobixibat-d5 是 Elobixibat 的氘代化合物。Elobixibat 的 CAS 号为 439087-18-0。Elobixibat 是回肠胆汁酸转运蛋白的抑制剂(小鼠、人和犬 IBAT 的 IC50:0.13 nM、0.53 nM 和 5.8 nM)。 Elobixibat 可用于慢性特发性便秘的研究。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-02830 | FCGRT & B2M Heterodimer Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
FCGRT & B2M Heterodimer Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.5 kDa and the accession number is Q8SPV9&Q8SPW0.
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TMPY-02829 | FCGRT & B2M Heterodimer Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
FCGRT & B2M Heterodimer Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44 kDa and the accession number is P13599&P07151.
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TMPY-02811 | FCGRT & B2M Heterodimer Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
FCGRT & B2M Heterodimer Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.5 kDa and the accession number is Q61559&P01887.
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TMPY-05650 | FCGRT & B2M Heterodimer Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated | Cynomolgus | HEK293 Cells | ||
FCGRT & B2M Heterodimer Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 45.3 kDa and the accession number is Q8SPV9&Q8SPW0.
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TMPY-05539 | FCGRT & B2M Heterodimer Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 Cells | ||
FCGRT & B2M Heterodimer Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.5 kDa and the accession number is P55899&P61769.
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TMPY-02082 | FCGRT & B2M Heterodimer Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
FCGRT & B2M Heterodimer Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.5 kDa and the accession number is P55899-1&P61769.
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TMPY-01938 | CD98 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
CD98 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.2 kDa and the accession number is P08195-1.
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TMPY-02358 | CD98 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
CD98 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.2 kDa and the accession number is P10852-2.
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TMPY-05148 | FCGRT & B2M Heterodimer Protein, Rat, Recombinant (His), Biotinylated | Rat | HEK293 Cells | ||
FCGRT & B2M Heterodimer Protein, Rat, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44 kDa and the accession number is P13599&P07151.
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TMPY-02209 | CUTC Protein, Human, Recombinant (His) | Human | E. coli | ||
Copper homeostasis protein cutC homolog, also known as CGI-32 and CUTC, is a cytoplasm and nucleus protein which belongs to theCutC family. CUTC may play a role in copper homeostasis. It can bind one Cu1+per subunit. Copper is an essential trace element to life and particularly plays a pivotal role in the physiology of aerobic organisms. Copper is a micronutrient that is required for proper metabolic functioning of most prokaryotic and eukaryotic organisms. To sustain an adequate supply of copper, a cell requires molecular mechanisms that control the metal content to avoid copper toxicity. This toxicity comes primarily from the reactivity of copper, which can lead to the generation of free radicals. In bacteria, two independent systems are responsible for maintaining the balance of copper within the cells ( Cop and Cut family proteins ). The Cut protein family is associated with copper homeostasis and involved in uptake, storage, delivery, and efflux of copper. CutC is a member of the Cut family and is suggested to be involved in efflux trafficking of cuprous ion. CutC is able to respond transcriptionally to copper and to participate in the control of copper homeostasis in E. faecalis.
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TMPY-05149 | FCGRT & B2M Heterodimer Protein, Cynomolgus, Recombinant (His), Biotinylated | Cynomolgus | HEK293 Cells | ||
FCGRT & B2M Heterodimer Protein, Cynomolgus, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.5 kDa and the accession number is Q8SPV9&Q8SPW0.
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TMPY-05649 | FCGRT & B2M Heterodimer Protein, Mouse, Recombinant (His & Avi), Biotinylated | Mouse | HEK293 Cells | ||
FCGRT & B2M Heterodimer Protein, Mouse, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 46 kDa and the accession number is Q61559.
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TMPY-05147 | FCGRT & B2M Heterodimer Protein, Mouse, Recombinant (His), Biotinylated | Mouse | HEK293 Cells | ||
FCGRT & B2M Heterodimer Protein, Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 44.2 kDa and the accession number is Q61559&P01887.
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TMPY-03857 | MMGT1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
MMGT1 (Membrane Magnesium Transporter 1, also known as EMC5 and TMEM32) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. The encoded protein belongs to the membrane magnesium transporter (TC 1.A.67) family which is a group of magnesium transporters that are part of the TOG superfamily. It mediates Mg(2+) transport. MMGT1 is described as having 335 amino acids and five TMSs with an N-terminal cleavage site and some phosphorylation sites. It is widely expressed in the thyroid, bone marrow, and other tissues. Diseases associated with MMGT1 include Cercarial Dermatitis. Among its related pathways are the Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds, and Miscellaneous transport and binding events.
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TMPY-05036 | FCGRT & B2M Heterodimer Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells | ||
FCGRT & B2M Heterodimer Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 45.3 kDa and the accession number is NP_004098.1&NP_004039.1.
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TMPY-05448 | FCGRT & B2M Heterodimer Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 Cells | ||
FCGRT & B2M Heterodimer Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 45.3 kDa and the accession number is NP_004098.1&NP_004039.1.
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TMPY-03307 | CD98 Protein, Rat, Recombinant (His) | Rat | HEK293 Cells | ||
CD98 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.7 kDa and the accession number is Q794F9.
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TMPY-04631 | CD98 Protein, Rat, Recombinant (hFc) | Rat | HEK293 Cells | ||
CD98 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 75.8 kDa and the accession number is Q794F9.
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TMPH-01711 | ABCC1 Protein, Human, Recombinant (His) | Human | E. coli | ||
ABCC1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 35.9 kDa and the accession number is P33527.
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TMPY-01118 | SLC27A4/FATP4 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
SLC27A4/ATG4B complex might act as a new potential therapeutic target of lung tumor chemotherapy. The solute carrier 27A (SLC27A) gene family encodes fatty acid transport proteins (FATPs) and includes 6 members. Autism spectrum disorders (ASD) are now recognized as disorders caused by impaired early brain development, it is possible that functional abnormalities of SLC27A genes may contribute to the pathogenesis of ASD. The expression of SLC27A3 and SLC27A4 in human neural stem cells derived from human induced pluripotent stem cells, which suggested their involvement in the developmental stage of the central nervous system.
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TMPJ-00583 | CDH17 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Cadherin-17 is a single-pass type I membrane protein that belongs to the cadherin superfamily. Cadherin-17 consists of one extracellular region containing seven cadherin domains and one transmembrane region but it lacks the conserved cytoplasmic domain. Cadherin-17 is expressed in the gastrointestinal tract and pancreatic duct. Cadherins are calcium dependent cell adhesion proteins and preferentially interact with each other in a homophilic manner in connecting cells. Cadherin-17 may have a role in the morphological organization of liver and intestine and involved in intestinal peptide transport.
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TMPY-06611 | CD98 Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 Cells | ||
CD98 Protein, Human, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.19 kDa and the accession number is P08195-1.
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TMPH-00981 | ABCB1 Protein, Human, Recombinant (His) | Human | E. coli | ||
ABCB1 Protein, Human, Recombinant (His) is expressed in E. coli.
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TMPH-00206 | Pertactin autotransporter Protein, Bordetella pertussis, Recombinant (His & SUMO) | Bordetella pertussis | E. coli | ||
Agglutinogen that binds to eukaryotic cells; a process mediated by the R-G-D sequence. Pertactin may have a role in bacterial adhesion, and thus play a role in virulence. May contribute to the disease state of whooping cough. Pertactin autotransporter Protein, Bordetella pertussis, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 45.8 kDa and the accession number is P14283.
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TMPH-00652 | MMBP Protein, E. coli, Recombinant (His & Myc) | E. coli | E. coli | ||
Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Binds maltose and higher maltodextrins such as maltotriose.
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TMPH-02324 | SLC39A6 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
May act as a zinc-influx transporter. SLC39A6 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with C-6xHis tag. The predicted molecular weight is 35.0 kDa and the accession number is Q13433.
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TMPH-02123 | SLC2A9 Protein, Human, Recombinant (His) | Human | E. coli | ||
Urate transporter, which may play a role in the urate reabsorption by proximal tubules. Does not transport glucose, fructose or galactose.
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TMPH-00786 | BtuD Protein, Halobacterium salinarum, Recombinant (His) | Halobacterium salinarum | E. coli | ||
Required for corrinoid utilization. Probably part of the ABC transporter complex BtuCDF involved in cobalamin (vitamin B12) import. Probably responsible for energy coupling to the transport system.
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TMPH-03414 | RT0041 Protein, Rickettsia typhi, Recombinant (His & Myc) | Rickettsia typhi | E. coli | ||
Could be part of an ABC transporter complex. RT0041 Protein, Rickettsia typhi, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 15.7 kDa and the accession number is Q68XW4.
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TMPH-02333 | SLC25A19 Protein, Human, Recombinant (His) | Human | E. coli | ||
Mitochondrial transporter mediating uptake of thiamine pyrophosphate (ThPP) into mitochondria. SLC25A19 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 37.0 kDa and the accession number is Q9HC21.
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TMPH-00787 | BtuD Protein, Halobacterium salinarum, Recombinant | Halobacterium salinarum | E. coli | ||
Required for corrinoid utilization. Probably part of the ABC transporter complex BtuCDF involved in cobalamin (vitamin B12) import. Probably responsible for energy coupling to the transport system.
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TMPH-03591 | PsaA Protein, S. pneumoniae, Recombinant (His & Myc) | Streptococcus pneumoniae | E. coli | ||
Part of an ABC transporter complex involved in manganese import. PsaA Protein, S. pneumoniae, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 39.9 kDa and the accession number is P42363.
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TMPH-02323 | SLC30A8 Protein, Human, Recombinant (His) | Human | E. coli | ||
Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells. SLC30A8 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 43.6 kDa and the accession number is Q8IWU4.
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TMPH-00628 | GltI/YbeJ Protein, E. coli, Recombinant (His & SUMO) | E. coli | E. coli | ||
Part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake. Binds to both glutamate and aspartate. GltI/YbeJ Protein, E. coli, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 47.2 kDa and the accession number is P37902.
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TMPH-02177 | Tapasin Protein, Human, Recombinant (His & Myc) | Human | E. coli | ||
Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). Tapasin Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 49.4 kDa and the accession number is O15533.
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TMPJ-00533 | LYVE1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1 is a single-pass type I membrane protein. LYVE-1 is a CD44 homolog found primarily on lymphatic endothelial cells 1. LYVE-1 mainly expressed in endothelial cells lining lymphatic vessels. While LYVE-1 functions is a Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. LYVE-1 plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). It may act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
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TMPH-01390 | G6PC Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels. G6PC Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 17.1 kDa and the accession number is P35575.
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TMPH-02119 | SLC5A2 Protein, Human, Recombinant (His & Myc) | Human | E. coli | ||
Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1.; Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.
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TMPH-02554 | BCAT2 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli | ||
Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids. BCAT2 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 48.2 kDa and the accession number is O35855.
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TMPY-05062 | NRG2 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Neuregulin-2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ErbB family of receptors, neuregulin-2 induces the growth and differentiation of epithelial, neuronal, glial and other types of cells. A mutation in NRG2 disrupted the induction of nitrate-responsive genes after nitrate treatment by an ammonium-independent mechanism. The nitrate content in roots was lower in the mutants than in the wild type, which may have resulted from reduced expression of NRT1.1 (also called NPF6.3, encoding a nitrate transporter/receptor) and upregulation of NRT1.8 (also called NPF7.2, encoding a xylem nitrate transporter). NRG2 plays a key role in nitrate regulation in part through modulating NRT1.1 expression and may function with NLP7 via their physical interaction.
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TMPH-02979 | SLC30A8 Protein, Mouse, Recombinant (His) | Mouse | E. coli | ||
Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells. SLC30A8 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 43.0 kDa and the accession number is Q8BGG0.
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TMPH-01696 | SLC16A4 Protein, Human, Recombinant (His) | Human | E. coli | ||
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. SLC16A4 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 17.7 kDa and the accession number is O15374.
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TMPH-01389 | G6PC Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) | ||
Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production in the terminal step of glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels. G6PC Protein, Human, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 5.6 kDa and the accession number is P35575.
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TMPH-03561 | lsdB Protein, S. aureus, Recombinant (His & SUMO) | Staphylococcus aureus | E. coli | ||
Cell wall-anchored surface receptor that extracts heme from oxidized metHb to enable growth on hemoglobin as a sole iron source. Rapidly extracts heme from hemoglobin and transfers it to IsdA or IsdC, which then relays it to the membrane transporter/IsdEF for internalization. Promotes also resistance to hydrogen peroxide and killing by neutrophils. lsdB Protein, S. aureus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 41.6 kDa and the accession number is P0C7J5.
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TMPY-02979 | HMGN3 Protein, Human, Recombinant (His) | Human | E. coli | ||
HMGN3 belongs to the HMGN family and is expressed in the kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate, and uterus. Members of the HMGN family bind to nucleosomes without any specificity for the underlying DNA sequence. They affect the global and local structure of chromatin, as well as the levels of histone modifications, and thus play a role in epigenetic regulation of gene expression. HMGN3 regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. It also regulates the expression of SLC6A9, a glycine transporter that regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. Both insulin and glucagon levels can be affected by HMGN3. HMGN3 may play a role in ocular development and astrocyte function. It also modulates the expression of pancreatic genes involved in insulin secretion.
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TMPY-02983 | LYVE1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
LYVE1, also known as LYVE-1, is a type I integral membrane glycoprotein. It contains 1 Link domain and is mainly expressed in endothelial cells lining lymphatic vessels. LYVE1 acts as a receptor and binds to both soluble and immobilized hyaluronan. It may function in lymphatic hyaluronan transport and have a role in tumor metastasis. LYVE1 also is a cell surface receptor on lymphatic endothelial cells that can be used as a lymphatic endothelial cell marker, and sort these cells for experimental purposes. It also functions as a ligand-specific transporter trafficking between intracellular organelles and the plasma membrane. It plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding. It may act as a hyaluronan transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
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TMPK-00545 | HPX Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
Hemopexin (HPX) serves as scavenger and transporter of toxic plasma heme to the liver. HPX is formed by two four-bladed beta-propeller domains, resembling two thick disks that lock together at a 90 degrees angle. The heme is bound between the two beta-propeller domains in a pocket formed by the interdomain linker peptide.HPX, acting not only as a heme carrier but also displaying transient heme-based ligand binding and (pseudo-)enzymatic properties, could be considered a 'chronosteric' heme-protein.
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TMPK-01233 | LAMP5 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesicles. In the mouse forebrain, LAMP5 is expressed in a subpopulation of GABAergic neurons in the olfactory bulb and the striato-nigral system, where it is required for fine-tuning of GABAergic synaptic transmission. LAMP5 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 49.8 kDa and the accession number is Q9UJQ1-1.
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TMPH-00550 | Epstein-Barr virus (strain B95-8) BCRF1 Protein (His & Myc) | EBV | E. coli | ||
Plays a role in masking infected cells for immune recognition by cytotoxic T-lymphocytes. Down-regulates the expression of the host TAP1 gene (transporter associated with antigen processing), thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules. Inhibits IFN-gamma synthesis. Epstein-Barr virus (strain B95-8) BCRF1 Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 24.8 kDa and the accession number is P03180.
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TMPK-00659 | LAMP5 Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells | ||
Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesicles. In the mouse forebrain, LAMP5 is expressed in a subpopulation of GABAergic neurons in the olfactory bulb and the striato-nigral system, where it is required for fine-tuning of GABAergic synaptic transmission. LAMP5 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 24.17 kDa and the accession number is G7PGY6.
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