目录号 | 产品详情 | 靶点 | |
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T4171 | NMDAR iGluR | ||
PEAQX (NVP-AAM077) 是 NR2A 高效选择性 NMDA 受体拮抗剂,IC50值为270nM。 | |||
T3320 | NMDAR iGluR | ||
Dizocilpine Maleate (MK 801) 是一种选择性和非竞争性的 NMDA 受体拮抗剂,Kd 值为 37.2 nM。它用于治疗 NMDA 受体可能发挥重要作用的多种神经退行性疾病或疾病。 | |||
T16451 | Apoptosis NMDAR iGluR | ||
PEAQX tetrasodium hydrate (PEAQX tetrasodium hydrate (459836-30-7 free base)) 是一种可口服的NMDA 拮抗剂,具有有效性和选择性。PEAQX tetrasodium hydrate (459836-30-7 free base) 对 hNMDAR 1A/2A 的 IC50 值分别为 270 nM 对hNMDAR 1A/2B 的 IC50 值为29600 nM。 | |||
T1308 | Sodium Channel NMDAR Norepinephrine iGluR Histamine Receptor | ||
Orphenadrine hydrochloride (Mephenamin) 是一种非竞争性的NMDA 受体拮抗剂, Ki=6.0 ± 0.7 μM。 | |||
T62376 | |||
GNE-9278 是一种高度选择性的 NMDAR 正变构调节剂,能够作用于 GluN1 跨膜结构域 (TMD)。GNE-9278 可以作用于活化的 NMDAR,能够提高峰值电流和激动剂亲和力。 | |||
T82297 | |||
GluN1 (356-385) 是抗NMDAR脑炎抗原肽,能够降低海马神经元表面NMDAR簇密度。该肽段用于探讨抗NMDAR脑炎病理机制。 | |||
T82296 | |||
GluN1(359-378)为抗N-甲基-D-天冬氨酸受体(NMDAR)抗体,具有穿透血脑屏障的能力。该化合物主要应用于抗NMDAR脑炎治疗的免疫系统研究。 | |||
T24917 | |||
UBP684 is an NMDAR pan-PAM. UBP684 increases the maximal l-glutamate/glycine response while having minor subunit-specific effects on agonist potency. It robustly potentiates responses at all GluN1/GluN2 subtypes and at neuronal NMDARs. | |||
T3407 | NMDAR iGluR | ||
Rapastinel (TPPT-amide) 是 N-甲基-D-天冬氨酸受体 (NMDAR) 调节剂,也有部分激动剂特性。 | |||
T15408 | Others | ||
GNE 5729 is an NMDAR of brain permeable positive allosteric modulator (EC50: 37 nM for GluN2A; 4.7 and 9.5 μM for GluN2C and GluN2D, respectively). |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-01692 | NETO1 Protein, Human, Recombinant (His) | Human | HEK293 | ||
Neuropilin tolloid-like 1 (NETO1), a complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing transmembrane protein, is a novel component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDARs in the postsynaptic density. The N-methyl-D-aspartate receptor (NMDAR), a major excitatory ligand-gated ion channel in the central nervous system (CNS), is a principal mediator of synaptic plasticity. Both NETO1 and NETO2 share an identical and unique domain structure thus representing a novel subfamily of CUB- and LDLa-containing proteins. The cytoplasmic domains of NETO1 and NETO2 are not homologous to other known protein sequences but contain a conserved FXNPXY-like motif, which is essential for the internalization of clathrin-coated pits during endocytosis or may be implicated in intracellular signaling pathways. NETO1 and NETO2, have marked effects on receptor properties, increasing further the potential diversity of Kainate receptors (KARs) functional properties. NETO1 involves in the development and/or maintenance of neuronal circuitry. NETO1 regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory.
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TMPY-02750 | Neuroligin-1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 | ||
Neuroligin 1 (NLGN1) belongs to the type-B carboxylesterase/lipase family, is a synaptic cell-adhesion molecule that is enriched in postsynaptic densities where it may recruit receptors, channels, and signal-transduction molecules to synaptic sites of cell adhesion. Neuroligins consists of five members (NLGN1, NLGN2, NLGN3, NLGN4, and NLGN4Y), which interact with beta-neurexins, and this interaction is involved in the formation of functional synapses. The extracellular domain of functional Neuroligin 1 associates as a dimer when analyzed by sedimentation equilibrium. Neuroligin 1 has a unique N-linked glycosylation pattern in the neuroligin family, and glycosylation and its processing modify neuroligin activity. Neuroligin 1 is a potent trigger for the de novo formation of synaptic connections, and it has recently been suggested that it is required for the maturation of functionally competent excitatory synapses. The persistent expression of Neuroligin 1 is required for the maintenance of NMDAR-mediated synaptic transmission, which enables the normal development of synaptic plasticity and long-term memory in the amygdala of adult animals.
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TMPY-01726 | Neuroligin-1 Protein, Human, Recombinant (His) | Human | HEK293 | ||
Neuroligin 1 (NLGN1) belongs to the type-B carboxylesterase/lipase family, is a synaptic cell-adhesion molecule that is enriched in postsynaptic densities where it may recruit receptors, channels, and signal-transduction molecules to synaptic sites of cell adhesion. Neuroligins consists of five members (NLGN1, NLGN2, NLGN3, NLGN4, and NLGN4Y), which interact with beta-neurexins, and this interaction is involved in the formation of functional synapses. The extracellular domain of functional Neuroligin 1 associates as a dimer when analyzed by sedimentation equilibrium. Neuroligin 1 has a unique N-linked glycosylation pattern in the neuroligin family, and glycosylation and its processing modify neuroligin activity. Neuroligin 1 is a potent trigger for the de novo formation of synaptic connections, and it has recently been suggested that it is required for the maturation of functionally competent excitatory synapses. The persistent expression of Neuroligin 1 is required for the maintenance of NMDAR-mediated synaptic transmission, which enables the normal development of synaptic plasticity and long-term memory in the amygdala of adult animals.
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