目录号 | 产品详情 | 靶点 | |
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T6975 | Others GlyT Endogenous Metabolite | ||
Sarcosine (Methylglycine) 是 I 型甘氨酸转运蛋白 (GlyT1) 的竞争性抑制剂和 N-甲基-D-天冬氨酸受体 (NMDAR) 共激动剂,通过增加甘氨酸的浓度增强 NMDA 受体的功能,可用于精神分裂症的研究。 | |||
T8394 | Endogenous Metabolite NMDAR iGluR | ||
D-Serine ((R)-Serine) 是一种具有独特的神经递质特性的神经胶质-突触相互作用中涉及的内源性氨基酸,是 NMDA 谷氨酸受体的有效共激动剂。D-Serine 在主要的 NMDAR 依赖性过程中具有主要的调节作用,包括 NMDAR 介导的神经传递,神经毒性,突触可塑性和细胞迁移。 | |||
T13112L1 | Others | ||
Tat-NR2B9c acetate (NA-1 acetate) 是一种突触后密度 95 (PSD-95) 抑制剂,对 PSD-95d2 (PSD-95 PDZ domain 2) 和 PSD-95d1 的 EC50 值分别为 6.7 nM 和 670 nM。它破坏 PSD-95/NMDAR 相互作用,抑制 NR2A 和 NR2B 与 PSD-95 的结合,IC50 值分别为 0.5 μM 和 8 μM。它还抑制神经元一氧化氮合酶 (nNOS)/PSD-95 相互作用,并具有神经保护功效。 | |||
T7355 | Others iGluR | ||
IC87201 是 PSD95-nNOS 相互作用的抑制剂,可抑制 nMDAR 诱导的一氧化氮和 cGMP 的形成,可用于缺血性中风和疼痛的研究。 | |||
T3826 | NF-κB TLR Akt PI3K | ||
Polygalasaponin F 是从瓜子金中提取的齐墩果烷型三萜皂苷,可通过调节TLR4-PI3K/AKT-NF-kB 信号通路减少神经炎症细胞因子的分泌,能降低炎性细胞因子肿瘤坏死因子 α 的释放。 | |||
T10781 | NMDAR iGluR | ||
CGP 78608 hydrochloride 是 NMDA 受体甘氨酸结合位点的特异性拮抗剂 (IC50 = 6 nM)。 CGP 78608 hydrochloride 具有抗惊厥活性。 CGP 78608 hydrochloride 增强 GluN1/GluN3A 介导的甘氨酸电流(估计 EC50 = 26.3 nM)。 | |||
T1186 | Potassium Channel NMDAR iGluR | ||
Ifenprodil tartrate 是典型的非竞争性 NMDA 受体拮抗剂,抑制 GIRK (Kir3),通过基底 GIRK 活性减少内向电流,有用做脑血管舒张试剂的潜力。它对 NR1A/NR2B 受体亲和力是 NR1A/NR2A 受体的 400 倍。 | |||
TQ0233 | NMDAR iGluR | ||
Traxoprodil (CP101606) 是一种有效的和选择性的NMDA 拮抗剂,能够保护海马神经元,其 IC50=10 nM。 | |||
T1946 | NMDAR iGluR | ||
Felbamate (W-554) 是非镇静性抗痉挛剂,可通过降低中枢神经系统紊乱的电活动起作用。 | |||
T22798 | NMDAR iGluR | ||
Gavestinel (GV 150526) 是一种非竞争性的 NMDA 受体拮抗剂,具有有效性、选择性和口服活性。Gavestinel 可与 NMDA 受体的甘氨酸位点结合,其结合亲和力(pKi 值)为 8.5。Gavestinel 可用于急性缺血性脑卒中研究。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-01692 | NETO1 Protein, Human, Recombinant (His) | Human | HEK293 | ||
Neuropilin tolloid-like 1 (NETO1), a complement C1r/C1s, Uegf, Bmp1 (CUB) domain-containing transmembrane protein, is a novel component of the NMDAR complex critical for maintaining the abundance of NR2A-containing NMDARs in the postsynaptic density. The N-methyl-D-aspartate receptor (NMDAR), a major excitatory ligand-gated ion channel in the central nervous system (CNS), is a principal mediator of synaptic plasticity. Both NETO1 and NETO2 share an identical and unique domain structure thus representing a novel subfamily of CUB- and LDLa-containing proteins. The cytoplasmic domains of NETO1 and NETO2 are not homologous to other known protein sequences but contain a conserved FXNPXY-like motif, which is essential for the internalization of clathrin-coated pits during endocytosis or may be implicated in intracellular signaling pathways. NETO1 and NETO2, have marked effects on receptor properties, increasing further the potential diversity of Kainate receptors (KARs) functional properties. NETO1 involves in the development and/or maintenance of neuronal circuitry. NETO1 regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory.
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TMPY-02750 | Neuroligin-1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 | ||
Neuroligin 1 (NLGN1) belongs to the type-B carboxylesterase/lipase family, is a synaptic cell-adhesion molecule that is enriched in postsynaptic densities where it may recruit receptors, channels, and signal-transduction molecules to synaptic sites of cell adhesion. Neuroligins consists of five members (NLGN1, NLGN2, NLGN3, NLGN4, and NLGN4Y), which interact with beta-neurexins, and this interaction is involved in the formation of functional synapses. The extracellular domain of functional Neuroligin 1 associates as a dimer when analyzed by sedimentation equilibrium. Neuroligin 1 has a unique N-linked glycosylation pattern in the neuroligin family, and glycosylation and its processing modify neuroligin activity. Neuroligin 1 is a potent trigger for the de novo formation of synaptic connections, and it has recently been suggested that it is required for the maturation of functionally competent excitatory synapses. The persistent expression of Neuroligin 1 is required for the maintenance of NMDAR-mediated synaptic transmission, which enables the normal development of synaptic plasticity and long-term memory in the amygdala of adult animals.
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TMPY-01726 | Neuroligin-1 Protein, Human, Recombinant (His) | Human | HEK293 | ||
Neuroligin 1 (NLGN1) belongs to the type-B carboxylesterase/lipase family, is a synaptic cell-adhesion molecule that is enriched in postsynaptic densities where it may recruit receptors, channels, and signal-transduction molecules to synaptic sites of cell adhesion. Neuroligins consists of five members (NLGN1, NLGN2, NLGN3, NLGN4, and NLGN4Y), which interact with beta-neurexins, and this interaction is involved in the formation of functional synapses. The extracellular domain of functional Neuroligin 1 associates as a dimer when analyzed by sedimentation equilibrium. Neuroligin 1 has a unique N-linked glycosylation pattern in the neuroligin family, and glycosylation and its processing modify neuroligin activity. Neuroligin 1 is a potent trigger for the de novo formation of synaptic connections, and it has recently been suggested that it is required for the maturation of functionally competent excitatory synapses. The persistent expression of Neuroligin 1 is required for the maintenance of NMDAR-mediated synaptic transmission, which enables the normal development of synaptic plasticity and long-term memory in the amygdala of adult animals.
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