T2506
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CDK
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AZD-5438 有效抑制 CDK1,CDK2,CDK9,IC50值分别为 16 nM, 6 nM, 20 nM,但它对 GSK3β,CDK5,CDK6 的抑制作用较弱。 |
T10783
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PPAR
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CGS 15435是一种有效的血栓素(TxA2)合成酶抑制剂(IC50: 1 nM)。CGS 15435作用于 PGI2合成酶、环氧合酶和脂合酶比作用于血栓素合成酶选择性低得多。 |
T22126
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GlyT
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Org 25543 hydrochloride 是一种有效的选择性甘氨酸转运蛋白 2 型 (GlyT2) 抑制剂(hGlyT2 的 IC50 = 16 nM)。在 CHO 细胞的甘氨酸摄取测定中,对 GlyT1 或 56 种其他常见生物靶标 (≥ 100 μM) 没有显示活性。 |
T23145
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Others
AChR
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PHA 543613 是一种特异性 α7 nAChR 激动剂 (Ki = 8.8 nM) ,可用于阿尔茨海默病和精神分裂症认知缺陷的研究。 |
T30517
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BMS-354326 is a bio-active chemical. |
T34571
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SCH 54388 is a biochemical. |
T33261
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MDK-5432, also known as AMPA stabilizer (R,R)-2a, is the most potent AMPA stabilizer. |
T70420
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PHA-543613 hydrochloride acts as a potent and selective agonist for the α7 subtype of neural nicotinic acetylcholine receptors, with a high level of brain penetration and good oral bioavailability. It is under development as a possible treatment for cognitive deficits in schizophrenia. |
T26148
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RU 25434 is a semi-synthetic aminoglycoside antibiotic. |
TN1270
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Others
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(3R)-5,7-Dihydroxy-6-methyl-3-(4'-hydroxybenzyl)chroman-4-one is a natural product |