目录号 | 产品详情 | 靶点 | |
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T1100 | Antibacterial Antibiotic | ||
Polymyxin B Sulfate (Poly-RX) 是一个阳离子型表面活性剂抗生素剂,能够提高细胞膜的渗透性。 | |||
T15027 | Calcium Channel | ||
Cyclopiazonic acid 是一种神经毒性次级代谢产物 (SM),源于A. flavus,是一种纳摩尔内质网钙 ATP 酶抑制剂 (Ca2+ATPase; SERCA),是植物细胞死亡的有效诱导剂。 | |||
T20754 | Others | ||
Deltamethrin (RU 22974) 是一种具有神经毒性的拟除虫菊酯杀虫剂,在大鼠中能够产生一系列可逆的运动症状(如包括后肢僵硬、舞蹈性关节炎)。 | |||
TL0001 | Others HIF/HIF Prolyl-Hydroxylase | ||
Dencichine (ODAP) 是抑制从三七中分到的非蛋白氨基酸,可抑制 HIF-prolyl hydroxylase-2 的活性。 | |||
T13664 | Others | ||
DSP-4 hydrochloride (Neurotoxin DSP 4 (hydrochloride)) 是一种高选择性的神经毒素,主要是来自蓝斑 (LC) 的神经元,容易通过血脑屏障。它对成年和发育中大鼠去甲肾上腺素能神经元具有神经毒性作用,可用于中枢和外周去甲肾上腺素能神经元的暂时选择性降解。 | |||
TN1831 | Antioxidant | ||
Macranthoside A (Kalopanaxsaponin H) 是一种从地黄中提取的三萜糖苷,属于环烯醚萜类化合。Macranthoside A 具有抗炎、抗氧化、抗菌和神经保护活性,抑制促炎细胞因子的产生和抑制炎症信号通路的激活,有助于中和有害的自由基,保护细胞免受氧化损伤,可以促进神经元的存活和生长,并防止氧化应激或神经毒性化合物引起的神经元细胞死亡,具有治疗神经退行性疾病、心血管疾病和肝损伤的潜力。 | |||
T75280 | |||
Prilocaine acetate 是一种氨基酰胺。Prilocaine acetate 是一种Na/K-ATPase 抑制剂。Prilocaine acetate 具有神经毒性作用。 | |||
T36356 | |||
Highly neurotoxic cell-permeable analog of PHF6. Induces aggregation of Tau peptides. | |||
T70224 | |||
Bupivacaine is a BK/SK, Kv1, Kv3, TASK-2 K Channel and voltage-gated Na channel blocker used as an anesthetic. It maybe neurotoxic at high does, inducing apoptosis in neuroblastoma cells. It acts by binding to the intracellular portion of voltage-gated sodium channels and blocking sodium influx into nerve cells. | |||
T40627 | |||
Trichodesmine, a dehydropyrrolizidine alkaloid, exhibits hepatotoxic, pneumotoxic, and neurotoxic effects in vivo. |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPH-02527 | ASS1 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli | ||
One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues.
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TMPH-01595 | KMO Protein, Human, Recombinant (His) | Human | E. coli | ||
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable).
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TMPH-02106 | SH3PXD2A Protein, Human, Recombinant (His & Myc) | Human | E. coli | ||
Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide.
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TMPJ-00990 | S100B Protein, Mouse, Recombinant (His) | Mouse | E. coli | ||
S100-B, is an acidic protein with a molecular weight of 21 kDa belonging to the S100 family. S100-B contains two EF-hand-type calcium-binding motifs separated by a hinge region with a hydrophobic cleft. S100-B plays an important role in neurodevelopment, differentiation, and brain construction. S100-B has neuroprotective effects, but at high concentrations S100-B is neurotoxic. Extracellular concentration of S100-B increases following brain damage, which easily penetrates into cerebrospinal fluid in brain damage and then into the blood. S100-B is expressed and produced by astrocytes in vertebrate brains and in the CNS, and the astrocytes are the major cells producing S100-B protein in gray matter, as well as oligodendrocytes are the predominant S100-B in protein producing cells in white matter. The major advantage of using S100-B is that elevations in serum or CSF levels provide a sensitive measure for determining CNS injury at the molecular level before gross changes develop, enabling timely delivery of crucial medical intervention before irreversible damage occurs. In addition, S100-B, which is also present in Mouse melanocytes, is a reliable marker for melanoma malignancy both in bioptic tissue and in serum.
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