目录号 | 产品详情 | 靶点 | |
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T74129 | |||
L-Homocysteic acid (L-HCA) 是一种内源性兴奋性氨基酸,可作为NMDA 受体激动剂 (EC50: 14 μM)。L-Homocysteic acid 具有神经毒性,可用于神经系统疾病的研究。 | |||
T75588 | |||
Bitis Armata Venom (Southern Adder Venom) 是一种蛇毒毒液,能够从南方蝰蛇中获得。Bitis Armata Venom 通过与 nAChR 拟位素结合表现出神经毒性活性。 | |||
T80428 | Sodium Channel | ||
Jingzhaotoxin-34是一种含35个氨基酸残基的多肽神经毒素,能特异性抑制TTX-S钠电流(IC50约85 nM),对大鼠背根神经节TTX-R钠电流无显著作用。 | |||
TN3351 | GABA Receptor | ||
Aflatrem is a tremorgenic mycotoxin with acute neurotoxic effects, a single low dose of aflatrem is able to induce degeneration of neuronal processes in hippocampal neurotransmitter systems. Aflatrem potentiates the gamma-aminobutyric acid (GABA)-induced | |||
T80699 | |||
β Amyloid(28-35) human 是一种具有神经毒性的β-淀粉样肽,能够与神经元膜结合,影响其二级结构并加剧阿尔茨海默病的神经毒性。该肽段对酸性磷脂DPH表现出非均向性作用,从而增加脂质膜双层内部的流动性。该核心片段由脂质诱导形成。 | |||
T80167 | |||
αC-Conotoxin PrXA为麻痹肽类神经毒素,亦是竞争性nAChR拮抗剂,对α1β1εδ(成人型)和α1β1γδ(胎儿型)nAChR的IC50值分别为1.8 nM和3.0 nM。该化合物通过与α-bungarotoxin竞争nAChR的α/δ及α/γ亚基界面,展现出对神经肌肉型nAChR的高度特异性。 | |||
T79459 | Endogenous Metabolite | ||
17β-HSD10-IN-2(compound 11)是一款基于苯并噻唑脲结构的17β-羟基类固醇脱氢酶10型(17β-HSD10)抑制剂,后者为一种具有多功能性的线粒体酶。该抑制剂未触发线粒体脱靶现象,且不具备细胞毒性或神经毒性。17β-HSD10-IN-2可用于研究阿尔茨海默病(AD)和激素依赖型癌症。 | |||
T73782 | |||
Prostaglandin J2 (PGJ2) 是前列腺素 D2 (PGD2) 的一种内源性代谢物,是一种有效的 PGD2 受体 (DP) 激动剂,对 hDP 和 hCRTH2 的 Ki 分别为 0.9 nM 和 6.6 nM。Prostaglandin J2 刺激细胞内环 AMP 的产生,EC50值为 1.2 nM。Prostaglandin J2 诱导氧化应激和神经细胞凋亡。Prostaglandin J2 诱导泛素化 (Ub) 蛋白的积累/聚集。Prostaglandin J2 具有高度神经毒性,可导致许多神经退行性疾病,包括阿尔茨海默病 (AD) 和帕金森病 (PD)。 | |||
T75587 | |||
Dendroaspis Viridis Venom (Western Green Mamba Venom) 是从 Dendroaspis Viridis (绿曼巴蛇) 提取的蛇毒,其中含有多种毒蕈碱毒素亚型,这些亚型靶向不同的毒蕈碱受体 (mAChR)。该毒液是一种由小分子和多肽/蛋白质组成的复杂混合物,显示出神经毒性、细胞毒性、心脏毒性、肌肉毒性以及多种酶活性。进一步研究表明,这些毒素具有抗肿瘤、抗菌、抗凝和镇痛的潜在活性。 | |||
T38214 | |||
1-Deoxysphingosine (m18:1(4E)) is an atypical sphingolipid that contains a double bond at the 4E native position and is formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis.1,2 Plasma levels of 1-deoxysphingosine (m18:1(4E)) are increased in patients with chronic idiopathic axonal neuropathy (CIAP) and diabetic distal symmetrical polyneuropathy (DSPN).3 |1. Steiner, R., Saied, E.M., Othman, A., et al. Elucidating the chemical structure of native 1-deoxysphingosine. J. Lipid Res. 57(7), 1194-1203 (2016).|2. Alecu, I., Othman, A., Penno, A., et al. Cytotoxic 1-deoxysphingolipids are metabolized by a cytochrome P450-dependent pathway. J. Lipid Res. 58(1), 60-71 (2017).|3. Hube, L., Dohrn, M.F., Karsai, G., et al. Metabolic syndrome, neurotoxic 1-deoxysphingolipids and nervous tissue inflammation in chronic idiopathic axonal polyneuropathy (CIAP). PLoS One 12(1):e0170583, (2017). |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPH-02527 | ASS1 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli | ||
One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues.
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TMPH-01595 | KMO Protein, Human, Recombinant (His) | Human | E. coli | ||
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract (Probable).
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TMPH-02106 | SH3PXD2A Protein, Human, Recombinant (His & Myc) | Human | E. coli | ||
Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide.
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TMPJ-00990 | S100B Protein, Mouse, Recombinant (His) | Mouse | E. coli | ||
S100-B, is an acidic protein with a molecular weight of 21 kDa belonging to the S100 family. S100-B contains two EF-hand-type calcium-binding motifs separated by a hinge region with a hydrophobic cleft. S100-B plays an important role in neurodevelopment, differentiation, and brain construction. S100-B has neuroprotective effects, but at high concentrations S100-B is neurotoxic. Extracellular concentration of S100-B increases following brain damage, which easily penetrates into cerebrospinal fluid in brain damage and then into the blood. S100-B is expressed and produced by astrocytes in vertebrate brains and in the CNS, and the astrocytes are the major cells producing S100-B protein in gray matter, as well as oligodendrocytes are the predominant S100-B in protein producing cells in white matter. The major advantage of using S100-B is that elevations in serum or CSF levels provide a sensitive measure for determining CNS injury at the molecular level before gross changes develop, enabling timely delivery of crucial medical intervention before irreversible damage occurs. In addition, S100-B, which is also present in Mouse melanocytes, is a reliable marker for melanoma malignancy both in bioptic tissue and in serum.
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