目录号 | 产品详情 | 靶点 | |
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T9605 | Nucleoside Antimetabolite/Analog PKC | ||
Sangivamycin (NSC-65346) 是蛋白激酶 C (PKC) 的有效抑制剂 (Ki = 10 μM)。 Sangivamycin 对多种人类癌症细胞具有抗增殖活性。 | |||
T8334 | Others | ||
CADD522 (MFCD00167693) 是 runt 相关转录因子-2 (RUNX2)-DNA 结合的抑制剂(IC50:10 nM),具有抗肿瘤作用。 | |||
T6018 | P-gp | ||
Zosuquidar trihydrochloride (LY-335979 trihydrochloride) 是一种P-糖蛋白抑制剂,Ki 值为 59 nM。 | |||
T8649 | mTOR | ||
TMBIM6 antagonist-1 (BAX-inhibitor-1) 是有潜力的TMBIM6拮抗剂,能够抑制 TMBIM6 与 mTORC2 结合,抑制 mTORC2 活性,调节TMBIM6 释放 Ca2+。 | |||
T9078 | CDK | ||
LY3405105 (1-Piperidinecarboxylic acid, 4-[[5-methyl-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-7-yl]amino]-, 1-[(2E)-4-(dimethylamino)-1-oxo-2-buten-1-yl]-3-pyrrolidinyl ester) 是一种新型 CDK7 抑制剂。 | |||
T17155 | Apoptosis Reactive Oxygen Species | ||
Trabectedin (Ecteinascidin 743) 是一种四氢异喹啉生物碱,有抗肿瘤的活性, 通过与 DNA 的小沟结合,阻断应激诱导的蛋白质的转录,诱导 DNA 骨架裂解和癌细胞凋亡,并增加 MCF-7 和 MDA-MB-453 细胞中 ROS 的生成。Trabectedin 在软组织肉瘤和卵巢癌中具有的研究价值。 | |||
T7311 | Autophagy | ||
Oxyphenisatin acetate 是oxyphenisatin 的前体药物,可抑制乳腺癌细胞系 MCF7、T47D、HS578T 和 MDA-MB-468 的生长。 | |||
T69860 | |||
PSB-15160是治疗雌激素依赖性肿瘤的化合物,对MCF7(乳腺)、NCI-H460(肺)和SF-268 (NCS)细胞的生长具有抑制作用。 | |||
T5132 | Apoptosis | ||
9-dihydro-13-acetylbaccatin III (9-DHAB III) 是一种制备紫杉醇类似物的中间体。 | |||
T7018 | transporter | ||
WZB117 是葡萄糖转运蛋白 1 抑制剂,可下调糖酵解,诱导细胞周期停滞,有抗癌细胞生长的作用。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPK-00785 | ANXA2 Protein, Mouse, Recombinant (His) | Mouse | E. coli | ||
ANXA2, highly expressed in invasive breast cancer cells, is closely related with poor prognosis, and acts as a molecular switch to EGFR activation. ANXA2 expression is inversely correlated with cell sensitivity to gefitinib. Knockdown of ANXA2 expression in MDA-MB-231 cells increased the gefitinib induced cell death. When ANXA2 was overexpressed in MCF7 cells, the gefitinib induced cell death was decreased. Furthermore, the phosphorylation of ANXA2 at Tyr23 is negatively correlated with the sensitivity of TNBC to gefitinib.
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TMPK-00784 | ANXA2 Protein, Human, Recombinant (His) | Human | E. coli | ||
ANXA2, highly expressed in invasive breast cancer cells, is closely related with poor prognosis, and acts as a molecular switch to EGFR activation. ANXA2 expression is inversely correlated with cell sensitivity to gefitinib. Knockdown of ANXA2 expression in MDA-MB-231 cells increased the gefitinib induced cell death. When ANXA2 was overexpressed in MCF7 cells, the gefitinib induced cell death was decreased. Furthermore, the phosphorylation of ANXA2 at Tyr23 is negatively correlated with the sensitivity of TNBC to gefitinib.
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