目录号 | 产品详情 | 靶点 | |
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T61062 | |||
ERGi-USU-6 (mesylate) 是一种新型选择性的 ERG 阳性前列腺癌,IC50 值为 0.089 μM,它是一种 ERGi-USU-6 盐衍生物。 | |||
T82447 | |||
Ergtoxin-1为钾离子通道阻断剂,源于墨西哥毒蝎Centruroides noxius的毒液。该化合物具有阻断神经、心脏及内分泌细胞ERG-K+通道的功能。 | |||
T14380 | CSF-1R HER Sodium Channel | ||
AZD7507 是口服具有活力的CSF-1R 抑制剂,具有抗肿瘤作用。 | |||
T28379 | |||
PF-1163B is an antifungal agent form Penicillium sp. II. PF-1163B inhibits ergosterol (ERG) synthesis with IC50 value of 34 ng/ml. PF-1163B showed potent growth inhibitory activity against pathogenic fungal strain Candida albicans but did not show cytotox | |||
T4641 | Others Potassium Channel DNA/RNA Synthesis | ||
Branaplam (LMI 070) 是一种高效、选择性和口服活性的小分子 SMN2 剪接调节剂,对 SMN 的 EC50为 20 nM。它可提高全长 SMN 蛋白并延长其生存期,也抑制 hERG,IC50为 6.3 μM。 | |||
T77660 | Wnt/beta-catenin | ||
TINK-IN-1 是一种具有选择性和高效性的 TNIK 抑制剂(IC50:8 nM)。TINK-IN-1 抑制结直肠癌细胞活力,可用于研究智力发育障碍。 | |||
T1291 | Potassium Channel 5-HT Receptor HER | ||
Cisapride (R 51619) 是一种5-HT4受体激动剂,还是 hERG 抑制剂。它可作用于肠道中的血清素受体,促进肠道蠕动,增加胃排空并减少食管反流。 | |||
T68113 | EGFR 5-HT Receptor | ||
Naluzotan hydrochloride (PRX 00023 hydrochloride) 是一种小分子、非氮杂吡酮、5-羟色胺(5-HT)1A 受体激动剂和sigma-1受体拮抗剂。在之前的临床试验中,该化合物在400多名患者中被证明安全且耐受性良好。 | |||
T67694 | Parasite | ||
ZY-19489是一种具有抗疟作用的化合物, 是一种潜在的单剂量根治性恶性疟原虫和间日疟原虫疟疾的药物,已获得美国 FDA 的孤儿药认定。 | |||
T30260 | HER P-gp CCR | ||
AZD-5672 是 CCR5 的拮抗剂,IC50 为 0.32 nM。 AZD-5672 抑制 hERG 心脏离子通道结合和 P-gp 介导的地高辛转运,IC50 为 7.3 μM 和 32 μM。 AZD-5672 可用于类风湿性关节炎的研究。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPH-02227 | ERG Protein, Human, Recombinant (His) | Human | Yeast | ||
Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.
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TMPH-03447 | ERG11 Protein, S. cerevisiae, Recombinant (GST) | Saccharomyces cerevisiae | E. coli | ||
Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
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TMPH-03460 | ERG26 Protein, S. cerevisiae, Recombinant (His & Myc) | SVG-Saccharomyces cerevisiae | E. coli | ||
Essential enzyme in the ergosterol biosynthetic pathway. Part of a 3 enzyme system that catalyzes the sequential removal of the 2 methyl groups at the sterol C-4 position, converting 4,4-dimethylzymosterol to zymosterol. Catalyzes the second step, an oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group.
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