目录号 | 产品详情 | 靶点 | |
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T67842 | Others | ||
ERG240 是支链氨基酸转氨酶 1 (BCAT1) 抑制剂。ERG240 有潜力用于癌症、类风湿性关节炎和骨病相关研究。 | |||
T60051 | Others | ||
VPC-18005 是一种荧光素酶抑制剂。 VPC-18005 抑制 ERG 诱导的转录并直接与 ERG-ETS 结构域相互作用,从而破坏 ERG 与 DNA 的结合。 | |||
T7198 | EGFR Potassium Channel | ||
E-4031是甲磺酰苯胺III 类抗心律失常药,选择性地阻断hERG 钾通道。 | |||
T7145 | Others | ||
NSC-139021 (ERGi-USU) 是一种具有高度选择性的ERG 阳性癌细胞生长抑制剂,抑制不同细胞系的IC50值为 30-400 nM。 | |||
T0801 | Potassium Channel HER CXCR | ||
Tannic acid (Gallotannic acid) 是新型hERG 通道阻塞剂,IC50为 3.4 μM。 | |||
T68359 | |||
DB1255 is a ERG/DNA binding inhibitor which targets the DNA-binding activity of the human ERG transcription factor. | |||
T4612 | EGFR Potassium Channel HER | ||
NS309 是选择性钙依赖性钾离子通道 SK/IK 的激活剂,在 BK 通道上没有激活作用。 | |||
T2280 | Estrogen Receptor/ERR EGFR Potassium Channel Estrogen/progestogen Receptor HER | ||
Endoxifen Z-isomer (EDX)是 Tamoxifen 重要的代谢产物,在表达 ERα的乳腺癌细胞中发挥抗雌激素作用。它以浓度依赖的方式抑制 hERG, IC50值为1.6μM。 | |||
T1266 | Apoptosis Potassium Channel 5-HT Receptor Caspase Na+/Ca2+ Exchanger HER AChR Histamine Receptor | ||
Terfenadine ((±)-Terfenadine) 是一种hERG 开放通道抑制剂,IC50为 204 nM。它也是一种 H1 组胺受体拮抗剂,通过调节Ca2+稳态在黑素瘤细胞中起到有效的细胞凋亡诱导作用。 Terfenadine 诱导 ROS 依赖性细胞凋亡,同时激活Caspase-4,-2,-9。 | |||
T3192 | Potassium Channel HER Autophagy | ||
NS1643 是一种有效的人类 ether-a-go-go 相关基因 (hERG) KV11.1 通道激活剂,EC50 为 10.5 μM。它增加了复极保留,展示出新型抗心律失常的方法。它通过减少通道失活,在高浓度下,对 erg2 (Kv11.2) 电流有明显影响。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPH-02227 | ERG Protein, Human, Recombinant (His) | Human | Yeast | ||
2-oxoglutarate dehydrogenase (E1) component of the 2-oxoglutarate dehydrogenase complex (OGDHC), which mediates the decarboxylation of alpha-ketoglutarate. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A.
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TMPH-03447 | ERG11 Protein, S. cerevisiae, Recombinant (GST) | Saccharomyces cerevisiae | E. coli | ||
Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol.
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TMPH-03460 | ERG26 Protein, S. cerevisiae, Recombinant (His & Myc) | SVG-Saccharomyces cerevisiae | E. coli | ||
Essential enzyme in the ergosterol biosynthetic pathway. Part of a 3 enzyme system that catalyzes the sequential removal of the 2 methyl groups at the sterol C-4 position, converting 4,4-dimethylzymosterol to zymosterol. Catalyzes the second step, an oxidative decarboxylation that results in a reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group.
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