T13421
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ALK
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(-)-Cevimeline hydrochloride hemihydrate ((-)-SNI-2011) 是一种新型mAChR 激动剂,是一种治疗干燥综合征口干症的候选治疗药物。 |
T12489
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Dopamine Receptor
5-HT Receptor
AChR
Histamine Receptor
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Pimethixene (Calmixen) 是抗组胺和抗血清素剂,用作抗偏头疼剂。它是高效多靶点拮抗剂。 |
T12489L
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Dopamine Receptor
5-HT Receptor
AChR
Histamine Receptor
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Pimethixene maleate (Pimetixene maleate) 是一种高效的 5-HT2B 受体拮抗剂,具有镇静和镇咳活性。Pimethixene maleate 抑制 5-HT1A,5-HT2A,5-HT2B,5-HT2C,组胺 H1,多巴胺 D2 和 D4.4 以及毒蕈碱 M1 和 M2,可用于研究儿童干咳和刺激性咳嗽。 |
T16443
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Others
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PCS1055 dihydrochloride is an effective, selective, and competitive muscarinic M4 receptor antagonist (IC50: 18.1 nM and a Kd: 5.72 nM). PCS1055 dihydrochloride is also a potent AChE inhibitor (IC50 s: 22 nM and 120 nM for electric eel and human AChE, res |
T12020
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AChR
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Metixene hydrochloride is an anticholinergic antiparkinsonian agent. |
T23452
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Others
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muscarinic M1 receptor antagonist |
T19882
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Apoptosis
Antioxidant
Calcium Channel
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Bryonolic acid (20-epi-Bryonolic acid) 是一种从 Sandoricum indicum 提取的三萜类化合物,具有免疫调节、抗炎,抗氧化和抗癌等活性,通过抑制Ca2+内流和调节Ca2+-CaMKII-CREB信号通路中的基因表达来避免PC12细胞免受NMDA诱导的细胞凋亡反应。 |
T28063
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ML169 is a selective and brain penetrant M1 positive allosteric modulator (PAM). |
T13460
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Others
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(+)-Cevimeline hydrochloride hemihydrate ((+)-SNI-2011) 是一种有效的 mAChR 激动剂。 |
T22951
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Others
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CB1 receptor antagonist/inverse agonist |