目录号 | 产品详情 | 靶点 | |
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T81485 | |||
Phoenixin-14 (PNX-14) TFA 是具抗焦虑、心脏保护及神经保护效果的穿透大脑屏障神经肽。它通过上调GnRH受体mRNA调控垂体促性腺激素分泌,并促进胰岛素释放。此外,Phoenixin-14 TFA保护小鼠免受缺血/再灌注(IR)伤害,通过降低ROS、提高GSH减缓氧化应激。 | |||
T70763 | |||
KR-67607, also known as NTX-101 is novel selective 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitor. KR-67607 decreased 4-hydroxynonenal expression and increased antioxidant and mucus secretion in BAC-treated rat eyes. KR-67607 showed its protective effects against ischemia-reperfusion-induced eye injury. KR-67607 effectively reduced cortisol levels in mouse eyes and maintained the trabecular meshwork (TM) structure in the presence of transient ischemic stress. Furthermore, KR-67607 reversed the elevation of intra-ocular pressure (IOP), suggesting that the TM structure maintained by KR-67607 prevented the excessive rise in IOP that exacerbates glaucoma. | |||
T78371 | |||
Ac2-26 ammonium是一种具抗炎作用的annexin 1 N末端肽。该化合物能够通过伴侣介导的自噬(CMA)机制降低溶酶体中的IKKβ蛋白含量,从而改善肺缺血再灌注损伤,并在哮喘大鼠模型中抑制气道炎症以及高反应性的表现。 | |||
T78562 | |||
FX-06 (Fibrin-derived peptide Bβ15-42)为纤维蛋白Bbeta链衍生的肽类化合物。通过与VE-cadherin结合并阻断白细胞的迁移,FX-06激活了以VE-cadherin为中心的信号通路。该化合物主要应用于缺血/再灌注损伤和登革热休克综合征(DSS)的相关研究。 | |||
T70063 | |||
GYKI 52466 is an allosteric AMPA receptor antagonist. It selectively inhibits AMPA-induced inward currents (IC50 = 7.5 µM) over NMDA- or GABA-induced inward currents in primary rat hippocampal neurons at 50 µM but also inhibits kainate-induced inward currents in the same cells (IC50 = 11 µM).2 GYKI 52466 (10 µM) reduces the amplitude of spontaneous excitatory postsynaptic currents (EPSCs) in the same cells. It increases the latency to seizure onset and reduces mortality in a rat model of generalized tonic-clonic seizures induced by 4-aminopyridine (4-AP) when administered at doses of 25 and 50 mg/kg. GYKI 52466 (30 mg/kg) prevents neuronal damage in the CA1 region of the hippocampus in a rat model of global ischemia-reperfusion injury induced by four-vessel occlusion. | |||
T80420 | Apoptosis | ||
TAT-NEP1-40 acetate 是促进脑卒中后轴突再生和功能恢复的候选分子。该化合物能够抵御PC12细胞的氧和葡萄糖剥夺(OGD)损伤,并促进神经突生长。它通过抑制神经元凋亡(apoptosis)作用,保护大脑免受缺血再灌注伤害,并能有效传递至大鼠的脑内。 | |||
T72145 | |||
Montelukast (MK0476) dicyclohexylamine 是一种有效、选择性且具口服活性的半胱氨酸白三烯受体1 (CysLT1) 拮抗剂,用于哮喘和肝损伤预防研究。它在肠缺血-再灌注损伤中展现抗氧化作用,减轻心脏损伤,并降低嗜酸性粒细胞对哮喘气道的浸润。此外,亦被用于COVID-19的研究。 | |||
T73989 | |||
Tirilazad是一种21-氨基类固醇非糖皮质激素,具有抑制脂质过氧化的能力。它对于脑或脊髓中因创伤、中风、缺血再灌注损伤所致的损害有减轻作用。此外,Tirilazad还展现出针对新型肺炎病毒的抗病毒活性,并在缺血性中风中提供神经保护,适用于蛛网膜下腔出血研究场景。 | |||
T60316 | |||
AV123 (化合物 12) 是一种无细胞毒性的RIPK1抑制剂,IC50值为12.12 μM。AV123 阻断 TNF-α 诱导的坏死性细胞死亡,EC50值为1.7 μM,但不阻断凋亡性细胞的死亡。AV123 可用于脑、心和肾的缺血再灌注损伤等慢性坏死性病症、炎症性疾病、神经退行性疾病和感染性疾病的研究。 | |||
TP2195 | Others | ||
Nitric Oxide Synthase (599-613) Blocking Peptide, Bovine Endothelial Cell (Ac-Pro-Tyr-Asn-Ser-Ser-Pro-Arg-Pro-Glu-Gln-His-Lys-Ser-Tyr-Lys-Cys) is a peptide that inhibits the function of NOSs as a result it blocks the production of NO. Because of the invol |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-04424 | MST3 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
Aberrant STK24 expression was an independent prognostic indicator in lung adenocarcinoma patients. Its dysregulation was associated with its DNA copy number alteration and methylation. STK24/CCM3-regulated exocytosis plays an important role in the protection of kidneys from ischemia-reperfusion injury.
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TMPJ-00082 | NGAL/Lipocalin-2 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
Lipocalin-2, also known as Neutrophil Gelatinase-Associated Lipocalin (NGAL), is a secretory protein of the lipocalin superfamily. Lipocalin-2 contains a signal peptide that enables it to be secreted and form complexes with matrix metalloproteinase-9 (MMP-9) through disulfide bonds. Similar to other lipocalin family members, Lipocalin-2 is involved in diverse cellular processes, including the transport of small hydrophobic molecules, protection of MMP-9 from proteolytic degradation, and cell signaling. Furthermore, Lipocalin-2 can tightly bind to bacterial siderophore through a cell surface receptor, possibly serving as a potent bacteriostatic agent by sequestering iron, regulating innate immunity and protecting kidney epithelial cells from ischemia–reperfusion injury. This protein is mainly expressed in neutrophils and in lower levels in the kidney, prostate, and epithelia of the respiratory and alimentary tracts.Recent evidence also suggests its role as a biomarker for renal injury and inflammation.
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