目录号 | 产品详情 | 靶点 | |
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T77163 | |||
Pexelizumab (h5G1.1-SC)为一种针对C5补体成分的人源化单克隆抗体。该化合物可抑制凋亡(apoptosis)和白细胞浸润,常用于研究脑缺血再灌注损伤和心肌梗死。 | |||
T1208 | Apoptosis Others Endogenous Metabolite | ||
Citicoline sodium (CDP-choline) 是一种合成细胞膜组分磷脂酰胆碱的中间体,有神经保护作用。 | |||
T41251 | |||
Taprostene (CG-4203) 是一种合成的、化学稳定的前列环素 (PGI2) 类似物。Taprostene 对猫急性心肌缺血再灌注后内皮和心肌有保护作用。Taprostene 增强细胞保护作用,同时减少不必要的血液动力学影响。 | |||
T37379 | Akt PI3K | ||
Protectin D1 (Neuroprotectin D1) 是神经细胞产生的神经保护素 ,是一种潜在的心脏保护剂。Protectin D1 通过调节 PI3K/AKT 信号通路缓解心肌缺血/再灌注损伤,抑制咪喹莫特诱导的银屑病样皮肤炎症。 | |||
TN1875 | BCL Caspase p53 | ||
Liriodenine is a potent inhibitor of topoisomerase II (EC 5.99.1.3) both in vivo and in vitro, it has antitumor, antibacterial and antifungal activities, it can suppress ventricular arrhythmias induced by myocardial ischaemia reperfusion, through inhibiti | |||
T83727 | |||
Tat-NTS肽是一种能穿透细胞的肽,由HIV-1 Tat蛋白的转导域与对应于脂联素A1重复III域残基228-237的10个氨基酸肽链接而成,扮演核转运信号(NTS)的角色。它通过阻断脂联素A1与进口素β之间的蛋白质-蛋白质相互作用,阻止脂联素A1在初级鼠海马神经元中的核内转运。Tat-NTS抑制初级鼠海马神经元在葡萄糖-氧剥夺及再灌注诱导的细胞凋亡。在体内,Tat-NTS(10 mg/kg)有效减少了由中脑动脉闭塞(MCAO)引起的缺血-再灌注损伤模型小鼠的梗塞体积和神经元凋亡,并缩短了在Morris水迷宫测试中达到平台的时间。 | |||
T68547 | |||
SNJ-1945 is a calpain inhibitor with more favorable retinal penetration, high oral bioavailability, and long half-life. SNJ1945 rescued defective function in lissencephaly. SNJ-1945 protects SH-SY5Y cells against MPP(+) and rotenone. SNJ-1945 reduces murine retinal cell death in vitro and in vivo. SNJ-1945 has good aqueous solubility, can prevents the heart from KCl arrest-reperfusion injury associated with the impairment of total Ca(2+) handling by inhibiting the proteolysis of alpha-fodrin as a cardioplegia. | |||
T78887 | Reactive Oxygen Species | ||
ROS-IN-2 (compound 85) 为次狼烷三萜衍生物,具有抑制细胞内过量ROS及其他氧化应激源生成的作用,从而保护线粒体避免受损。该化合物在心肌缺血/再灌注(MI/R)损伤研究中具有潜在应用价值。 | |||
TP1373L | NF-κB | ||
Ac2-26 acetate 是一种膜联蛋白 A1(AnxA1) 的活性 N 末端肽。 Ac2-26 acetate 降低 AnxA1 蛋白表达并抑制受损肺组织中 NF-κB 和 MAPK 通路的激活。 Ac2-26 acetate 可减轻缺血再灌注诱导的急性肺损伤。 | |||
T73456 | |||
DRP1i27是一种有效抑制人源Drp1(动力蛋白相关蛋白1)的化合物。它通过与Drp1的GTPase位点结合,并与Gln34及Asp218形成氢键来发挥作用。DRP1i27主要针对Drp1介导的线粒体裂变细胞系模型,能有效防止模拟缺血再灌注引起的损伤。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-04424 | MST3 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
Aberrant STK24 expression was an independent prognostic indicator in lung adenocarcinoma patients. Its dysregulation was associated with its DNA copy number alteration and methylation. STK24/CCM3-regulated exocytosis plays an important role in the protection of kidneys from ischemia-reperfusion injury.
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TMPJ-00082 | NGAL/Lipocalin-2 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
Lipocalin-2, also known as Neutrophil Gelatinase-Associated Lipocalin (NGAL), is a secretory protein of the lipocalin superfamily. Lipocalin-2 contains a signal peptide that enables it to be secreted and form complexes with matrix metalloproteinase-9 (MMP-9) through disulfide bonds. Similar to other lipocalin family members, Lipocalin-2 is involved in diverse cellular processes, including the transport of small hydrophobic molecules, protection of MMP-9 from proteolytic degradation, and cell signaling. Furthermore, Lipocalin-2 can tightly bind to bacterial siderophore through a cell surface receptor, possibly serving as a potent bacteriostatic agent by sequestering iron, regulating innate immunity and protecting kidney epithelial cells from ischemia–reperfusion injury. This protein is mainly expressed in neutrophils and in lower levels in the kidney, prostate, and epithelia of the respiratory and alimentary tracts.Recent evidence also suggests its role as a biomarker for renal injury and inflammation.
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