目录号 | 产品详情 | 靶点 | |
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T8122 | Others Antibacterial Antibiotic | ||
Mafenide Acetate 是一种磺酰胺类抗菌剂,可用于烧伤创面。它通过抑制核苷酸合成,对革兰氏阳性和革兰氏阴性生物有活性。 | |||
T0921 | Antibacterial Antibiotic Autophagy | ||
Sulfabenzamide (N-Sulfanilylbenzamide) 是一种磺胺类抗菌剂,可单独使用或与磺胺噻唑和磺胺乙酰胺一起用作阴道内的局部抗菌制剂。 | |||
T2204 | DHFR Antifolate Antibacterial | ||
Diaveridine (AI3-23935) 是二氢叶酸还原酶的抑制剂,对于野生型 DHFR 的Ki 值为 11.5 nM。它也是一种抗菌剂。 | |||
T19578 | Others | ||
TH-263 是二芳基磺酰胺衍生物,可用作 TH-257 的阴性对照,对 LIMK1 和 LIMK2 均无抑制活性。 | |||
T0767 | Antibacterial Antibiotic Autophagy | ||
Sulfapyridine (2-Sulfapyridine) 是一种磺酰胺类抗生素,是 Sulfasalazine 的代谢产物。它抑制重组 P. carinii 二氢蝶呤合成酶,IC50为 0.18 μM。它具有抗菌,抗炎和抗风湿作用。 | |||
T0885 | Antibacterial Antibiotic Autophagy | ||
Sulfamethoxazole (STX 608) 是磺胺类抗菌素,用于细菌感染。Sulfonamides 是对氨基苯甲酸的竞争性拮抗剂。 | |||
T34609 | iGluR | ||
Selurampanel (BGG492) 是一种具有口服活性和选择性的竞争性 AMPA 谷氨酸受体拮抗剂,是一种喹唑啉二酮磺酰胺。Selurampanel 可用于研究癫痫、偏头痛和耳鸣。 | |||
T0126 | ATPase Potassium Channel Autophagy | ||
Diazoxide (Proglycem) 是一种 ATP 敏感性的钾离子通道激活剂,是一种苯并噻二嗪衍生物,是一种用于高血压急症的外周血管扩张剂。 | |||
T3279 | DNA/RNA Synthesis Antibacterial Antibiotic | ||
Silver sulfadiazine (Dermazin) 是一种磺胺类抗生素,具有抗菌和抗真菌活性。它的通磺胺部分(SD-SDZ) 对细菌生长有双重抑制作用,可阻止细菌叶酸吸收以及 DNA 合成。它释放的银结合并破坏 DNA 结构,阻止细菌 DNA 复制。 | |||
T1026 | Antibacterial Antibiotic Carbonic Anhydrase | ||
Mafenide hydrochloride (4-Aminomethylbenzenesulfonamide hydrochloride) 是一种有效的磺酰胺类抗菌剂,可用于烧伤创面。它通过抑制核苷酸合成,对革兰氏阳性和革兰氏阴性生物均具有活性。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPJ-00731 | Carbonic Anhydrase 1 Protein, Human, Recombinant (His) | Human | E. coli | ||
Carbonic Anhydrase 1 (CA1) is a cytosolic enzyme, belonging to the alpha-carbonic anhydrase family. It is highly expressed in erythrocytes and acts as an early marker for erythroid differentiation. Carbonic anhydrase 1 plays a improtant role in many biological processes such as calcification, cellular respiration, bone resorption, acid-base balance. It is activated by imidazole, histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. At the same time, It is inhibited by sulfonamide derivatives and coumarins. In addition, CA1 is a zinc metalloenzyme that has reversible hydration of carbon dioxide. It can hydrate cyanamide to urea.
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TMPY-02133 | Carbonic Anhydrase VB Protein, Human, Recombinant (His) | Human | E. coli | ||
Carbonic anhydrase 5B, also known as carbonate dehydratase VB, carbonic anhydrase VB, CA-VB and CA5B, is amember of the alpha-carbonic anhydrase family. The strongest expression of CA5B / CA-VB is in heart, pancreas, kidney, placenta, lung, and skeletal muscle. It is not expressed in liver. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. CAs show extensive diversity in tissue distribution and in their subcellular localization. CA5B / CA-VB is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA5A / CA-VA. CA5B / CA-VB has a wider tissue distribution than CA5A / CA-VA, which is restricted to the liver. The differences in tissue distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic roles. CA5A / CA-VA is activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. It is inhibited by coumarins, sulfonamide derivatives such as acetazolamide and Foscarnet (phosphonoformate trisodium salt). CA5B / CA-VB is inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA), saccharin and Foscarnet (phosphonoformate trisodium salt).
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TMPY-01877 | CA5A Protein, Human, Recombinant (His) | Human | E. coli | ||
Carbonic anhydrase 5A, mitochondrial, also known as Carbonate dehydratase VA, Carbonic anhydrase VA, CA-VA and CA5A, is a member of thealpha-carbonic anhydrase family. Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. CA5A / CA-VA is activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. It is inhibited by coumarins, sulfonamide derivatives such as acetazolamide and Foscarnet (phosphonoformate trisodium salt).
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TMPY-01761 | Carbonic Anhydrase 3 Protein, Human, Recombinant (His) | Human | E. coli | ||
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes first discovered in 1933 that catalyze the reversible hydration of carbon dioxide. CAs participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. Carbonic anhydrases (CAs) form a family of enzymes that catalyze the rapid conversion of carbon dioxide and water to bicarbonate and protons, a reaction that occurs rather slowly in the absence of a catalyst. The active site of most carbonic anhydrases contains a zinc ion, they are therefore classified as metalloenzymes. Several forms of carbonic anhydrase occur in nature. The primary function of the enzyme in animals is to interconvert carbon dioxide and bicarbonate to maintain acid-base balance in blood and other tissues, and to help transport carbon dioxide out of tissues. Plants contain a different form called β-carbonic anhydrase, which, from an evolutionary standpoint, is a distinct enzyme, but participates in the same reaction and also uses a zinc ion in its active site. Carbonic anhydrase 3, also known as Carbonate dehydratase III, CA-III and CA3, is a cytoplasm protein which belongs to thealpha-carbonic anhydrase family. CA3 is activated by proton donors such as imidazole and the dipeptide histidylhistidine. It is inhibited by coumarins and sulfonamide derivatives such as acetazolamide. At 6 weeks gestation, transcripts accumulate at low levels in the somites and at high levels throughout the notochord. As gestation continues, CA3 becomes abundant in all developing muscle masses and continues at high to moderate levels in the notochord.
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