目录号 | 产品详情 | 靶点 | |
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T65237 | Others | ||
Glycine 7-amido-4-methylcoumarin hydrobromide 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T65237,CAS号为 113728-13-5。 | |||
T9626 | NMDAR | ||
Cycloleucine 是 NMDA 受体相关甘氨酸受体的拮抗剂,Ki 为 600 μM。Cycloleucine 也是 S-腺苷甲硫氨酸介导的甲基化的竞争性抑制剂,具有抗焦虑和细胞抑制作用。 | |||
T66213 | Others | ||
Boc-3-Hydroxy-1-adamantyl-D-glycine 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66213,CAS号为 361442-00-4。 | |||
T2963 | Endogenous Metabolite | ||
Cholic Acid (Cholate) 是肝脏产生的主要胆汁酸,与牛磺酸或甘氨酸缀合,有助于脂肪吸收和胆固醇排泄。 | |||
T8450 | NMDAR | ||
TCN 213 是一种可克服的(surmountable)、甘氨酸依赖的 GluN1/GluN2A NMDAR 选择性拮抗剂,当甘氨酸的含量为75、 750、7500 nM 时,IC50s 值分别为 0.55、3.5、40 μM。它可用于在药理学上监测 NMDAR 表达在发育中的皮层神经元中的转换。 | |||
T60034 | Others | ||
TH1085是OGG1的增强剂。 TH1085 刺激 DNA 修复并保护细胞免受环境危害百草枯 (PQ) 的侵害。 | |||
T82291 | Others | ||
Glycine, N-[(1,1-dimethylethoxy)carbonyl]thio-L-phenylalanyl-, methyl ester (compound 3b) 是一种化合物,其多肽链末端含有磺胺基团,主要应用于多肽与活性分子偶联化合物的合成。 | |||
T19857 | Apoptosis Autophagy | ||
Glyphosate (Atila) 是氨基酸甘氨酸的衍生物。它是一种除草剂,靶向并阻断植物合成芳香氨基酸所必需的莽草酸途径。 | |||
T6697 | DUB | ||
TCID (UCH-L3 Inhibitor) 是一种有效的选择性神经元泛素 C 末端水解酶 L3 的 DUB 抑制剂,IC50为 0.6 μM。它对 L1 具有 125 倍的选择性,可减少脑干和脊髓原代神经元中的甘氨酸转运蛋白 GlyT2 泛素化。 | |||
T4537 | HIV Protease Endogenous Metabolite | ||
Cholic acid sodium (SodiumCholate) 是肝脏中产生的主要胆汁酸,通常与牛磺酸或甘氨酸结合,有助于脂肪吸收和胆固醇排泄。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPH-00166 | Glycine oxidase Protein, Bacillus subtilis, Recombinant (His & SUMO) | Bacillus subtilis | E. coli | ||
Glycine oxidase Protein, Bacillus subtilis, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 56.9 kDa and the accession number is O31616.
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TMPJ-01118 | GNMT Protein, Human, Recombinant (His) | Human | E. coli | ||
Glycine N-Methyltransferase (GNMT) is a tetrameric cytosolic protein. GNMT catalyzes the synthesis of N-methylglycine from glycine using S-adenosylmethionine (AdoMet) as the methyl donor. It can affects DNA methylation by regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine, playing an important role in maintaining normal AdoMet levels. GNMT is highly expressed in liver. As a major folate-binding protein, GNMT takes part in the detoxification pathway. Defects in GNMT are the cause of hypermethioninemia. the patients with this deficiency are mild hepatomegaly and chronic elevation of serum transaminases.
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TMPH-02331 | GLRA1 Protein, Human, Recombinant (His & Myc) | Human | E. coli | ||
Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiated by ethanol. Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol.
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TMPY-03503 | GCSH Protein, Human, Recombinant (His) | Human | E. coli | ||
Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). GCSH is the H protein, which transfers the methylamine group of glycine from the P protein to the T protein. Defects in GCSH gene are a cause of nonketotic hyperglycinemia (NKH). Two transcript variants, one protein-coding and the other probably not protein-coding,have been found for GCSH gene. Also, several transcribed and non-transcribed pseudogenes of GCSH gene exist throughout the genome.
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TMPJ-00484 | SHMT1 Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
Serine Hydroxymethyltransferase Cytosolic (SHMT1) is a member of the SHMT family. SHMT1 is a cytoplasmic protein and exists as a homotetramer. SHMT1 catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one carbon unit for the synthesis of methionine, thymidylate, and purines in the cytoplasm. A reduction in SHMT1 levels would result in less glycine that could affect the nervous system by acting as an agonist to the NMDA receptor and this could be a mechanism behind Smith-Magenis syndrome.
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TMPH-03558 | LytM Protein, S. aureus, Recombinant (His) | Staphylococcus aureus | E. coli | ||
Peptidoglycan hydrolase (autolysin) specifically acting on polyglycine interpeptide bridges of the cell wall peptidoglycan. LytM Protein, S. aureus, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 35.9 kDa and the accession number is O33599.
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TMPH-00774 | SAM22 Protein, Glycine max, Recombinant (His) | Glycine max | P. pastoris (Yeast) | ||
Involved in disease resistance. SAM22 Protein, Glycine max, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 18.8 kDa and the accession number is P26987.
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TMPH-00770 | 2S albumin Protein, Glycine max, Recombinant (His) | Glycine max | P. pastoris (Yeast) | ||
This is a 2S seed storage protein.; binds to mammalian chromatin, preventing the normal formation of the kinetochore complex in the centromere and leading to the disruption of mitosis.
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TMPH-00772 | Leghemoglobin C2 Protein, Glycine max, Recombinant (His) | Glycine max | E. coli | ||
Provides oxygen to the bacteroids. This role is essential for symbiotic nitrogen fixation.
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TMPY-02235 | CSRP1 Protein, Mouse, Recombinant (His) | Mouse | E. coli | ||
CSRP1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 22 kDa and the accession number is P97315.
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TMPH-00771 | Ferritin-2 Protein, Glycine max, Recombinant (His & SUMO) | Glycine max | E. coli | ||
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
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TMPJ-01410 | LSM4 Protein, Human, Recombinant (His) | Human | E. coli | ||
U6 snRNA-associated Sm-like protein LSm4 (LSM4) is a member of the snRNP Sm proteins family. Sm-like proteins contain the Sm sequence motif and are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing. LSM4 forms a heteromer with a donut shape. The complexes are involved in various steps of RNA metabolism. LSM4 binds specifically to the 3-terminal U-tract of U6 snRNA. LSM4 contributes RNA protein interactions and structural changes which are essential during ribosomal subunit assembly.
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TMPH-00773 | RuBisCO large subunit Protein, Glycine max, Recombinant (His & SUMO) | Glycine max | E. coli | ||
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site.
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TMPH-00769 | 2S albumin Protein, Glycine max, Recombinant (His & SUMO) | Glycine max | E. coli | ||
This is a 2S seed storage protein.; binds to mammalian chromatin, preventing the normal formation of the kinetochore complex in the centromere and leading to the disruption of mitosis. 2S albumin Protein, Glycine max, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 32.2 kDa and the accession number is P19594.
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TMPY-01562 | CSRP1 Protein, Human, Recombinant (His) | Human | E. coli | ||
CSRP1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 21.4 kDa and the accession number is A0A384P5K2.
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TMPH-01110 | CIRBP Protein, Human, Recombinant (GST) | Human | E. coli | ||
CIRBP Protein, Human, Recombinant (GST) is expressed in E. coli.
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TMPH-02587 | CIRBP Protein, Mouse, Recombinant (His) | Mouse | E. coli | ||
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Promotes assembly of stress granules (SGs), when overexpressed. Seems to play an essential role in cold-induced suppression of cell proliferation. Acts as a translational repressor. Acts as a translational activator. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN.
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TMPH-01176 | CSRP3 Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
CSRP3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
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TMPH-01596 | AADAT Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).
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TMPH-00608 | Dihydrofolate reductase Protein, E. coli, Recombinant (His) | E. coli | E. coli | ||
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
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TMPH-03535 | Dihydrofolate reductase Protein, S. aureus, Recombinant (His & Myc) | Staphylococcus aureus | E. coli | ||
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Dihydrofolate reductase Protein, S. aureus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 25.6 kDa and the accession number is P99079.
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TMPH-01224 | Dihydrofolate reductase Protein, Human, Recombinant (His) | Human | E. coli | ||
Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2.
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TMPH-03581 | Dihydrofolate reductase Protein, S. epidermidis, Recombinant (His) | Staphylococcus epidermidis | E. coli | ||
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Dihydrofolate reductase Protein, S. epidermidis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 22.0 kDa and the accession number is P0C0P1.
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TMPY-02979 | HMGN3 Protein, Human, Recombinant (His) | Human | E. coli | ||
HMGN3 belongs to the HMGN family and is expressed in the kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate, and uterus. Members of the HMGN family bind to nucleosomes without any specificity for the underlying DNA sequence. They affect the global and local structure of chromatin, as well as the levels of histone modifications, and thus play a role in epigenetic regulation of gene expression. HMGN3 regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. It also regulates the expression of SLC6A9, a glycine transporter that regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. Both insulin and glucagon levels can be affected by HMGN3. HMGN3 may play a role in ocular development and astrocyte function. It also modulates the expression of pancreatic genes involved in insulin secretion.
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TMPH-01394 | GRIN1 Protein, Human, Recombinant (His) | Human | E. coli | ||
Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition. GRIN1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 64.6 kDa and the accession number is Q05586.
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TMPK-00191 | PILRA Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
Alzheimer's disease (AD) is a neurodegenerative disease characterized by a progressive decline in cognitive performance; Mild Cognitive Impairment (MCI) is instead an objective decline in cognitive performance that does not reach pathology. Paired immunoglobulin-like type 2 receptor alpha (PILRA) is a cell surface inhibitory receptor that was recently suggested to be involved in AD pathogenesis. In particular, the arginine-to-glycine substitution in position 78 (R78, rs1859788) was shown to be protective against AD.
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TMPK-00150 | FOLR1 Protein, Human, Recombinant (His & Avi) | Human | HEK293 Cells | ||
Folate Receptor 1 (FOLR1), also known as Folate Receptor alpha and Folate Binding Protein (FBP), is a 37 - 42 kDa protein that mediates the cellular uptake of folic acid and reduced folates. Dietary folates are required for many key metabolic processes including nucleotide and methionine synthesis, the interconversion of glycine and serine, and histidine breakdown. FOLR1 binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH.
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TMPJ-00979 | GSH-S Protein, Human, Recombinant (His) | Human | E. coli | ||
Glutathione Synthetase belongs to the eukaryotic GSH synthase family. Glutathione Synthetase is the second enzyme in the glutathione biosynthesis pathway. It catalyses the condensation of gamma-glutamylcysteine and glycine to form glutathione. Glutathione play an important role in a variety of biological functions, including detoxification of xenobiotics, protection of cells from oxidative damage by free radicals, and membrane transport. The protein functions as a homodimer to catalyze the second step of glutathione biosynthesis, which is the ATP-dependent conversion of gamma-L-glutamyl-L-cysteine to glutathione. Defects in Glutathione Synthetase can also cause the glutathione synthetase deficiency of erythrocytes, which is a mild form causing hemolytic anemia.
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TMPJ-00304 | ALK-1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells | ||
Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF-β superfamily of ligands, which mediates signaling of BMP9 (bone morphogenetic protein) and BMP10. ALK1 signaling is necessary for angiogenesis during embryogenesis, wound healing, and tumor growth. ALK-1 has a high degree of similarity in serine-threonine kinase subdomains, a glycine and serine rich region preceding the kinase-domain, and a C-terminal tail with other activin receptor-like kinase proteins. ALK-1 is mainly expressed in endothelial cells regulating proliferation and migration in vitro and angiogenesis in vivo. Mutations in ALK-1 as well as in endoglin are associated with hereditary hemorrhagic telangiectasia (HHT), suggesting ALK-1 plays a critical role for in the control of blood vessel development or repair.
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TMPY-02840 | Ubiquitin Activating Enzyme E1/UBA1 Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells | ||
UBE1, also known as UBA1, belongs to the ubiquitin-activating E1 family. UBE1 gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. UBE1 catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. It also catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Defects in UBA1 can cause spinal muscular atrophy X-linked type 2 (SMAX2), also known as X-linked lethal infantile spinal muscular atrophy, distal X-linked arthrogryposis multiplex congenita or X-linked arthrogryposis type 1 (AMCX1). Spinal muscular atrophy refers to a group of neuromuscular disorders characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. SMAX2 is a lethal infantile form presenting with hypotonia, areflexia, and multiple congenital contractures.
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