Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TCN 213 是一种可克服的(surmountable)、甘氨酸依赖的 GluN1/GluN2A NMDAR 选择性拮抗剂,当甘氨酸的含量为75、 750、7500 nM 时,IC50s 值分别为 0.55、3.5、40 μM。它可用于在药理学上监测 NMDAR 表达在发育中的皮层神经元中的转换。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 363 | 现货 | ||
5 mg | ¥ 952 | 现货 | ||
10 mg | ¥ 1,570 | 现货 | ||
25 mg | ¥ 3,160 | 现货 | ||
50 mg | ¥ 4,660 | 现货 | ||
100 mg | ¥ 6,650 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 987 | 现货 |
产品描述 | TCN 213 is an antagonist of NMDA receptor that has a selective for NR1/NR2A over NR1/NR2B |
靶点活性 | GluN1/GluN2A NMDAR:0.55-40 μM (IC50) |
体外活性 | TCN 213 antagonism of GluN1/GluN2A NMDA receptors was dependent on glycine but independent of glutamate concentrations in external recording solutions.?Antagonism by TCN 213 was surmountable and gave a Schild plot with unity slope.?TCN 213 block of GluN1/GluN2B NMDA receptor-mediated currents was negligible.?In cortical neurones, at a early developmental stage predominantly expressing GluN2B-containing NMDA receptors, TCN 213 failed to antagonize NMDA receptor-mediated currents or to prevent GluN2B-dependent, NMDA-induced excitoxicity.?In older cultures (DIV 14) or in neurones transfected with GluN2A subunits, TCN 213 antagonized NMDA-evoked currents.?Block by TCN 213 of NMDA currents inversely correlated with block by ifenprodil, a selective GluN2B antagonist. |
别名 | TCN213 |
分子量 | 376.54 |
分子式 | C18H24N4OS2 |
CAS No. | 556803-08-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (79.67 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.6558 mL | 13.2788 mL | 26.5576 mL | 66.394 mL |
5 mM | 0.5312 mL | 2.6558 mL | 5.3115 mL | 13.2788 mL | |
10 mM | 0.2656 mL | 1.3279 mL | 2.6558 mL | 6.6394 mL | |
20 mM | 0.1328 mL | 0.6639 mL | 1.3279 mL | 3.3197 mL | |
50 mM | 0.0531 mL | 0.2656 mL | 0.5312 mL | 1.3279 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
TCN 213 556803-08-8 Neuroscience NMDAR glycine-dependentlly Inhibitor TCN213 Ionotropic glutamate receptors inhibit iGluR surmountable monitor neurones TCN-213 pharmacologically selective inhibitor