目录号 | 产品详情 | 靶点 | |
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T37075 | Cannabinoid Receptor | ||
CB2R PAM 是一种口服活性大麻素 2 型受体(CB2Rs)阳性突变调节剂,它能增强 CP 55940 和 2-Arachidonylglycerol 刺激的 [35S]GTPγS 与 CB2 受体的结合,但在没有激动剂的情况下没有作用。CB2R PAM 在神经病理性疼痛小鼠模型中显示出抗损伤活性。 | |||
T37428 | TRP/TRPV Channel | ||
TRPC6-PAM-C20 是一种选择性 TRPC6 正变构调节剂。 TRPC6-PAM-C20 在表达 TRPC6 的 HEK 细胞中诱导胞内 Ca2+ 瞬时增加,EC50 为 2.37 μM。 TRPC6-PAM-C20 增强 OAG 诱导的血小板聚集。 | |||
TP1067 | TLR | ||
Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA) 是 Toll 样受体 1/2 激动剂,对人 TLR1/2 的EC50为 0.47 ng/mL。 | |||
T1111 | AChE | ||
Pralidoxime Chloride (2-PAM chloride) 是一种肟类化合物,对中毒乙酰胆碱酯酶具有恢复作用,可用于有机磷中毒的研究。 | |||
T33872 | |||
Pam 1392 is a chemotherapeutic agent. | |||
T29123 | AChR | ||
VU0152099 是选择性和可透过血脑屏障的 mAChR M4正变构调节剂,可增强 M4 对乙酰胆碱的反应,对大鼠 M4 受体的 EC50为 0.4 µM。 | |||
T9021 | GluR | ||
Ro0711401 是一种可口服的 mGlu1受体选择性正变构调节剂,EC50为 56 nM。 | |||
T23514 | GluR | ||
VU-1545 是一种代谢型谷氨酸受体 5 正变构调节剂,Ki 为 156 nM,EC50为 9.6 nM。 | |||
T9177 | iGluR | ||
BPAM344 是一种红藻氨酸受体亚基GluK1b、GluK2a 和GluK3a 的正变构调节剂。 | |||
T8991 | Opioid Receptor | ||
BMS986187 是一种有效的δ-阿片受体选择性正变构调节剂 (PAM),其 EC50= 0.03 μM,pKB= 6.02 (~1 μM)。BMS986187 对 μ 受体无明显 PAM 活性 (EC50=3 μM)。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-00392 | PAM Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
PAM Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 94.4 kDa and the accession number is P19021-2.
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TMPY-01035 | JAM-A Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
JAM-A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25 kDa and the accession number is Q9Y624-1.
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TMPY-00865 | JAM-A Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
JAM-A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50 kDa and the accession number is Q9BQB4-1.
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TMPY-00149 | PAM Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
PAM Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 104 kDa and the accession number is P19021-2.
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TMPK-00188 | JAM-A Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
junctional adhesion molecule A (JAM-A), a cell adhesion molecule, is highly elevated in human GBM cancer stem cells and predicts poor patient prognosis. While JAM-A is also highly expressed in other cells in the tumor microenvironment, specifically microglia and macrophages,JAM-A functions to suppress pathogenic microglial activation in the female tumor microenvironment, highlighting an emerging role for sex differences in the GBM microenvironment and suggesting that sex differences extend beyond previously reported tumor cell-intrinsic differences.
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TMPJ-00965 | TIM16 Protein, S. cerevisiae, Recombinant | S. cerevisiae | E. coli | ||
Mitochondrial import inner membrane translocase subunit TIM16 (TIM16) is an ssential component of the PAM complex. PAM complex is required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, TIM16 is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. TIM16 may act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation.
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TMPJ-01087 | TIM14 Protein, S. cerevisiae, Recombinant | S. cerevisiae | E. coli | ||
Mitochondrial import inner membrane translocase subunit TIM14 (TIM14) is an essential component of the PAM complex. PAM complex is required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, TIM14 is required to stimulate activity of mtHSP70 (SSC1). TIM14 belongs to the DnaJ family, which has been involved in Hsp40/Hsp70 chaperone systems. As a mitochondrial chaperone, TIM14 functions as part of the TIM23 complex import motor to facilitate the import of nuclear-encoded proteins into the mitochondria. TIM14 also complexes with prohibitin complexes to regulate mitochondrial morphogenesis, and has been implicated in dilated cardiomyopathy with ataxia.
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TMPH-01690 | TIM14 Protein, Human, Recombinant (GST) | Human | E. coli | ||
Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling. May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity.
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