目录号 | 产品详情 | 靶点 | |
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T28069 | AChR | ||
ML380 是一种高效的中枢神经系统渗透剂 M5 正变构调节剂,对人和大鼠 M5 的 EC50值分别为 190 和 610 nM。它对 M1 和 M3 mAChR 亚型具有中等选择性,可增加 Ach 对 M5 mAChR 的亲和力。 | |||
T29137 | AChR | ||
VU0453595 是有效的、高选择性的、全身活性的M1正变构调节剂 (PAM, EC50=2140 nM),在精神分裂症方面有研究价值。 | |||
T22404 | Others | ||
Pralidoxime Iodide, also named 2-PAM, is an antidote approved for reactivation of inhibited acetylcholinesterase (AChE) in organophosphate poisoning. | |||
T7699 | P450 GABA Receptor | ||
AZD7325 (AZD-7325) 是具有口服活性的α2和α3受体正向别构调节剂,Ki 分别是 0.3 和 1.3 nM。它是中等 CYP1A2和强效 CYP3A4诱导剂,有用于焦虑和 dravet 综合征相关的研究潜力。 | |||
TP2399 | |||
Palmitoyl tetrapeptide is an analog of the N-terminal part of lipoprotein from the outer membrane of E. coli. | |||
TP1962 | |||
Toll-like receptor 2/6 (TLR2/6) agonist. Induces TNF-α production in human mononuclear cells. Also induces proliferation and activation of mouse splenic B cells. | |||
T70460 | |||
HM5023507, an orally active dual inhibitor of δγ isoforms in immune signaling. HM5023507 inhibited PI3Kδ and PI3Kγ isoforms with greater than 100-fold selectivity against PI3Kα and PI3Kβ in recombinant enzymatic assays and in primary human immune cells with an exquisite selectivity against other targets. | |||
TP2282 | Others | ||
biotinylated Pam2CSK4, a toll-like receptor 2/6 agonist | |||
T81559 | |||
Pam3-Cys-Ala-Gly为合成细菌脂肽,具备激活巨噬细胞与B细胞的高效能力。 | |||
TP1068 | |||
Pam3CSK4 is a synthetic triacylated lipopeptide (LP) that mimics the acylated amino terminus of bacterial LPs. |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-00392 | PAM Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
PAM Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 94.4 kDa and the accession number is P19021-2.
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TMPY-01035 | JAM-A Protein, Human, Recombinant (His) | Human | HEK293 Cells | ||
JAM-A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25 kDa and the accession number is Q9Y624-1.
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TMPY-00865 | JAM-A Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
JAM-A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 50 kDa and the accession number is Q9BQB4-1.
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TMPY-00149 | PAM Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
PAM Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 104 kDa and the accession number is P19021-2.
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TMPK-00188 | JAM-A Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells | ||
junctional adhesion molecule A (JAM-A), a cell adhesion molecule, is highly elevated in human GBM cancer stem cells and predicts poor patient prognosis. While JAM-A is also highly expressed in other cells in the tumor microenvironment, specifically microglia and macrophages,JAM-A functions to suppress pathogenic microglial activation in the female tumor microenvironment, highlighting an emerging role for sex differences in the GBM microenvironment and suggesting that sex differences extend beyond previously reported tumor cell-intrinsic differences.
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TMPJ-00965 | TIM16 Protein, S. cerevisiae, Recombinant | S. cerevisiae | E. coli | ||
Mitochondrial import inner membrane translocase subunit TIM16 (TIM16) is an ssential component of the PAM complex. PAM complex is required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, TIM16 is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. TIM16 may act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation.
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TMPJ-01087 | TIM14 Protein, S. cerevisiae, Recombinant | S. cerevisiae | E. coli | ||
Mitochondrial import inner membrane translocase subunit TIM14 (TIM14) is an essential component of the PAM complex. PAM complex is required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, TIM14 is required to stimulate activity of mtHSP70 (SSC1). TIM14 belongs to the DnaJ family, which has been involved in Hsp40/Hsp70 chaperone systems. As a mitochondrial chaperone, TIM14 functions as part of the TIM23 complex import motor to facilitate the import of nuclear-encoded proteins into the mitochondria. TIM14 also complexes with prohibitin complexes to regulate mitochondrial morphogenesis, and has been implicated in dilated cardiomyopathy with ataxia.
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TMPH-01690 | TIM14 Protein, Human, Recombinant (GST) | Human | E. coli | ||
Mitochondrial co-chaperone which forms a complex with prohibitins to regulate cardiolipin remodeling. May be a component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. May act as a co-chaperone that stimulate the ATP-dependent activity.
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