目录号 | 产品详情 | 靶点 | |
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T21507 | P450 NO Synthase | ||
7-Ethoxyresorufin (Resorufin ethyl ether) 是细胞色素 P450 (尤其是CYP1A1) 的荧光底物和竞争性抑制剂,同时对 NO 合酶具有抑制作用。 | |||
T2S1434 | P450 | ||
Bergaptol (4-Hydroxybergapten) 是CYP3A4酶脱苄基作用的抑制剂(IC50:24.92 uM),具有抗癌、抗增殖作用。 | |||
T1540 | P450 Dopamine Receptor 5-HT Receptor Adrenergic Receptor AChR Norepinephrine Histamine Receptor | ||
Doxepin hydrochloride (Aponal) 是一种可口服的三环抗抑郁剂,是选择性组胺受体 H1拮抗剂。它也是 CYP450抑制剂,抑制 CYP450 2C19和 CYP450 1A2。 | |||
T0679 | NADPH-oxidase P450 Hydroxylase Antifungal Ras | ||
Ketoconazole (R-41400) 是一种咪唑类抗真菌剂,也是一种 CYP3A4 抑制剂。 | |||
T4190 | ATPase Adiponectin receptor | ||
Ticlopidine (PCR 5332) 是抗血栓前药。它是CYP2C19人肝细胞色素的抑制剂,抑制 CYP2C9 及 CYP3A4。他是变构CD39的非竞争性抑制剂,能够阻断 NTPDase 同工酶,对NTPDase2和NTPDase3的IC50分别为 170 µM 和 149 µM。 | |||
T19526 | P450 | ||
Pradefovir mesylate (Hepavir B) 是一种肝脏 CYP3A4 底物。在人肝微粒体中,Pradefovir 能够转化为 9-[2-(磷酸甲氧基)乙基]腺嘌呤,其Km=60 μM。 | |||
T1011 | P450 Hedgehog/Smoothened Antibiotic Autophagy Antifungal | ||
Itraconazole (R51211) 是三唑类抗真菌药,也是口服活性的Hedgehog 信号通路拮抗剂,IC50约为 800 nM。它也是 oxysterol-binding protein 抑制剂。它抑制羊毛甾醇 14α-脱甲基酶,从而抑制羊毛甾醇向麦角固醇的氧化转化。它有抗癌和抗血管作用。 | |||
TJS1159 | P450 Ferroptosis P-gp | ||
Chrysosplenetin 是青蒿和其他几种中草药中的一种多甲氧基化黄酮类天然产物,抑制 P-gp 活性并逆转由青蒿素诱导的上调的 P-gp 和 MDR1 水平。 | |||
T1415 | P450 Adrenergic Receptor PPAR | ||
Gemfibrozil (CI-719) 是一种PPAR-α激活剂,可作为降脂药。它也是P450非选择性抑制剂,对 CYP2C9、2C19、2C8 和 1A2 的Ki 值分别为 5.8、24、69 和 82 μM。 | |||
T1290 | Others Antibiotic Antifection Antifungal | ||
Oxiconazole nitrate (Ro 13-8996) 是广谱抗真菌药物,抑制T. tonsurans 和T.rubrum 的生长,MIC90值分别为 0.25 和 0.5 μg/mL。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPJ-00048 | CYPA Protein, Mouse, Recombinant | Mouse | E. coli | ||
Peptidyl-prolyl cis-trans isomerase A is a cytoplasm protein which belongs to the cyclophilin-type PPIase family and PPIase A subfamily. Cyclophilins(CyPs) are a family of proteins found in organisms ranging from prokaryotes to humans. These molecules exhibit peptidyl-prolyl isomerase activity, suggesting that they influence the conformation of proteins in cells. Cyclophilin A accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Cyclophilin A can interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions.
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TMPJ-01049 | CYPA Protein, Human, Recombinant | Human | E. coli | ||
Peptidyl-prolyl cis-trans isomerase A is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, which catalyzes the cis-trans isomerization of proline imidic peptide bonds. Cyclophilin A regulate many biological processes, including intracellular signaling, transcription, inflammation, and apoptosis. Cyclophilin is also incorporated into many viruses, including HIV1, where it has been speculated to be involved in functions such as viral assembly and infectivity. The immunosuppressive activity of cyclosporins has been correlated with their ability to form complexes with cyclophilins that inhibit calcineurin phosphatase activity and prevent incorporation of cyclophilin into viral particles. The cyclosporin/cyclophilin complex selectively binds and inactivates calcineurin, making it a useful inhibitor for studying calcineurin activity.
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TMPY-01593 | Cyclophilin A Protein, Mouse, Recombinant (His) | Mouse | E. coli | ||
Cyclophilin A Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 18.8 kDa and the accession number is P17742.
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TMPY-02177 | Cyclophilin A Protein, Human, Recombinant (His) | Human | E. coli | ||
Cyclophilin A Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 19.4 kDa and the accession number is P62937.
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