目录号 | 产品详情 | 靶点 | |
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T6888 | Guanylate cyclase Microtubule Associated NO Synthase Parasite Monoamine Oxidase | ||
Methylene Blue (Tetramethylthionine chloride) 是鸟苷酸环化酶,是单胺氧化酶 A 和 NO 合酶抑制剂。它有抗伤害感受、抗疟疾、抗抑郁和抗焦虑作用,可研究高铁血红蛋白血症、神经退行性疾病和异环磷酰胺引起的脑病。它是血管加压剂,用作色素内窥镜检查中的染料。 | |||
T5470 | MAO Monoamine Oxidase | ||
Lazabemide (Ro 19-6327) 是一种单胺氧化酶 B 的选择性的可逆抑制剂 ,但对 MAO-A 活性较低。它高浓度时具有抑制单胺摄取的作用,能够抑制去甲肾上腺素、血清素和多巴胺摄取,其IC50值分别为 86 μM、123 μM 和 >500 μM。它可用于研究帕金森和阿尔茨海默病。 | |||
T6651 | MAO Monoamine Oxidase | ||
Safinamide mesylate (EMD 1195686 mesylate) 是选择性的、有效的、可逆的单胺氧化酶 B 的抑制剂,对 MAO-A 选择性较低。它能够阻断钠通道和调节谷氨酸释放。它具有神经保护作用,可用于研究帕金森病、缺血脑卒中等疾病。 | |||
T0338 | MAO Dopamine Receptor 5-HT Receptor AChR AChE Monoamine Oxidase | ||
Minaprine 是一种单胺氧化酶 MAO-A 可逆性抑制剂,对乙酰胆碱酯酶有微弱抑制,是一种抗抑郁类化合物。 | |||
T67789 | MAO | ||
Bazinaprine 是一种选择性的、可逆的单胺氧化酶抑制剂(MAOI),是治疗抑郁症的候选化合物。Bazinaprine 对A 型单胺氧化酶显示出较强的抑制作用,对b 型单胺氧化酶只显示出较弱的抑制作用。Bazinaprine 在体内可逆,但在体外不可逆。 | |||
T67850 | MAO | ||
FCE 28073是一种 Monoamine oxidase B 抑制剂,IC50=0.45 μM。 | |||
T28380 | Dopamine Receptor 5-HT Receptor | ||
PF-184298 是一种血清素和去甲肾上腺素单胺再摄取抑制剂(SNRI),抑制多巴胺再摄取。 | |||
TN7211 | MAO | ||
Tetrahydroharmine (Leptaflorine) 是一种天然产物,存在于植物Banisteriopsis caapi cultivar Da Vine 的茎和枝中。四氢骆驼蓬碱是一种Monoamine oxidase A 抑制剂。 | |||
T10079 | MAO | ||
MAO-IN-1是一种高效的单胺氧化酶B (MAO B)抑制剂(IC50:20 nM),可用于研究神经系统相关疾病。 | |||
T77564 | |||
Coumarin102 (Exciton 480)是一种荧光染料。Coumarin102对Monoamine oxidase B、MAO-B和MAO-A具有较弱的抑制活性,可用来研究神经系统疾病。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPJ-00379 | AOC3 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells | ||
Membrane primary amine oxidase(AOC3), also known as vascular adhesion protein (VAP-1) and HPAO, this protein is a member of the semicarbazide-sensitive amine oxidase (SSAO) family. VAP-1 is a type 1 membrane-bound glycoprotein that has a distal adhesion domain and an enzymatically active amine oxidase site outside of the membrane, VAP-1 has adhesive properties, functional monoamine oxidase activity, and possibly plays a role in glucose handling, leukocyte trafficking, and migration during inflammation. This rise in metabolic products contributes to generating advanced glycation end-products and oxidative stress along with the monoamine detoxification in the organism. It is highly expressed on the endothelium of the lung and trachea, and absent from leukocytes and epithelial cells. Membrane-bound VAP-1 releases an active, soluble form of the protein, which may be conducive to increased inflammation and the progression of many vascular disorders. In particular, elevation of VAP-1 activity and the increased enzymatic-mediated deamination is proposed to play a role in renal and vascular disease, oxidative stress, acute and chronic hyperglycemia, and diabetes complications.
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TMPY-03056 | LSD1 Protein, Human, Recombinant (His & GST) | Human | Baculovirus Insect Cells | ||
LSD1 belongs to the flavin monoamine oxidase family. It contains 1 SWIRM domain and is a component of an RCOR/GFI/LSD1/HDAC complex. LSD1 interacts directly with GFI1 and GFI1B. LSD1 specifically removes histone H3K4me2 to H3K4me1 or H3K4me0 through a FAD-dependent oxidative reaction. When forming a complex with an androgen receptor (and possibly other nuclear hormone receptors), LSD1 changes its substrates to H3K9me2. Thus LSD1 is considered to act as a coactivator or a corepressor. It may play a role in the repression of neuronal genes. Alone, LSD1 is unable to demethylate H3 'Lys-4' on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity.
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