目录号 | 产品详情 | 靶点 | |
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T5032 | Others COX | ||
Iguratimod (T614) 是一种抗风湿药,作为 COX-2 的抑制剂,IC50 为 20 μM (7.7 μg/mL)。它还抑制巨噬细胞迁移抑制因子 (MIF),IC50值为 6.81 μM。 | |||
T0826 | Apoptosis COX Autophagy | ||
Meloxicam (Metacam) 是一种非甾体类抗炎剂,抑制COX 的活性,对 COX-2 和 COX-1 的IC50值分别为 0.49 µM 和 36.6 µM。 | |||
T15645 | COX | ||
Pamicogrel (KBT3022) 是一种环氧合酶 (COX) 抑制剂。 | |||
T0705 | COX PDE PPAR | ||
Triflusal (UR1501) 能够利用乙酰化COX-1途径,不可逆地减少血小板中血栓素B2的生成。 | |||
T3877 | NF-κB COX | ||
Esculentoside A 是一种三萜皂苷,从商陆根部分离得到。它在具有抗炎活性,对环氧合酶-2 具有选择性抑制活性。它通过抑制NF-κB 和丝裂原活化蛋白激酶信号通路抑制 LPS 诱导的急性肺损伤中的炎症反应。 | |||
T5431 | Antioxidant COX | ||
[10]-Shogaol (10-Shogaol) 是一种从生姜中提取的抗氧化剂,用于皮肤细胞增殖和迁移增强剂。它抑制 COX-2,IC50值为 7.5 μM,可能有降血脂和胰岛素增敏作用。 | |||
T1258 | COX Glutathione Peroxidase | ||
Nabumetone (BRL14777) 是一种非甾体抗炎药,是选择性COX-2抑制剂,其活性代谢物 6MNA 可抑制环加氧酶 I 和 II。 | |||
T5430 | Apoptosis COX | ||
[8]-Shogaol 是生姜中的一种刺激性酚类天然产物,可诱导人白血病细胞凋亡,抑制 COX-2的IC50为17.5 μM,具有抗血小板活性,IC50为5 μM。 | |||
T12580 | COX Epoxide Hydrolase | ||
PTUPB 是强效的sEH(IC50:0.9 μM)和COX-2(IC50:1.26 μM)的双向抑制剂。 | |||
T2405 | ATPase COX Antibacterial | ||
Revaprazan hydrochloride (YH1885) 是一种新型酸泵拮抗剂,可降低COX-2的表达,在幽门螺杆菌感染中,显著抑制炎症。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-01736 | COX-2 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells | ||
PTGS2, also known as COX-2, is s component of Prostaglandin-endoperoxide synthase (PTGS). PTGS, also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. PTGS2 is overexpressed in many cancers. The overexpression of PTGS2 along with increased angiogenesis and GLUT-1 expression is significantly associated with gallbladder carcinomas. Furthermore the product of COX-2, PGH2 is converted by prostaglandin E2 synthase into PGE2, which in turn can stimulate cancer progression. Consequently inhibiting COX-2 may have benefit in the prevention and treatment of these types of cancer. PTGS2 is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. It mediates the formation of prostaglandins from arachidonate and may have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
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TMPH-01179 | COX4I1 Protein, Human, Recombinant (His & SUMO) | Human | E. coli | ||
COX4I1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
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TMPH-01180 | COX5A Protein, Human, Recombinant (GST) | Human | E. coli | ||
COX5A Protein, Human, Recombinant (GST) is expressed in E. coli.
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TMPY-03511 | COX5B Protein, Human, Recombinant (His) | Human | E. coli | ||
Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Vb of the human mitochondrial respiratory chain enzyme.
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TMPY-03752 | COX4NB Protein, Human, Recombinant (His) | Human | E. coli | ||
COX4NB Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 25.6 kDa and the accession number is O43402.
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TMPH-02617 | COX5A Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli | ||
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
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TMPY-04908 | Coxsackievirus A16 (Cox A16) (strain G-10) VP1 Protein (Fc) | CV | Baculovirus Insect Cells | ||
Coxsackievirus A16 (Cox A16) (strain G-10) VP1 Protein (Fc) is expressed in Baculovirus insect cells with Fc tag. The predicted molecular weight is 59.5 kDa and the accession number is AAA50478.1.
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TMPY-04807 | Coxsackievirus A16 (Cox A16) (strain G-10) VP4 Protein (Fc) | CV | Baculovirus Insect Cells | ||
Coxsackievirus A16 (Cox A16) (strain G-10) VP4 Protein (Fc) is expressed in Baculovirus insect cells with Fc tag. The predicted molecular weight is 32.6 kDa and the accession number is AAA50478.1.
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TMPH-03639 | COX7A1 Protein, Trachypithecus cristatu, Recombinant (hFc) | Trachypithecus cristatus | HEK293 Cells | ||
N/A. COX7A1 Protein, Trachypithecus cristatu, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 31.9 kDa and the accession number is Q9N234.
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TMPJ-00704 | SCO1 Protein, Human, Recombinant (GST) | Human | E. coli | ||
Protein SCO1 Homolog, Mitochondrial (SCO1) is a member of the SCO1/2 family. SCO1 has a homodimer structure. SCO1 is located in mitochondrion and is highly expressed in muscle, heart, and brain. It is characterized by high rates of Oxidative Phosphorylation (OxPhos). SCO1 is thought to play a important role in cellular copper homeostasis, mitochondrial redox signaling and insertion of copper into the active site of COX. The defects of SCO1 can result in Mitochondrial Complex IV Deficiency (MT-C4D). A disorder of the mitochondrial respiratory chain has heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs.
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TMPY-03658 | ETHE1 Protein, Human, Recombinant (His) | Human | E. coli | ||
ETHE1, also known as HSCO, is a sulfur dioxygenase that localizes within the mitochondrial matrix. ETHE1 probably plays an important role in metabolic homeostasis in mitochondria. It may also function as a nuclear-cytoplasmic shuttling protein that binds transcription factor RELA/NFKB3 in the nucleus and exports it to the cytoplasm. ETHE1 can suppresses p53-induced apoptosis by preventing nuclear localization of RELA. Mutations in ETHE1 gene result in ethylmalonic encephalopathy. Ethylmalonic encephalopathy is an autosomal recessive, invariably fatal disorder characterized by early-onset encephalopathy, microangiopathy, chronic diarrhea, defective cytochrome c oxidase (COX) in muscle and brain, high concentrations of C4 and C5 acylcarnitines in blood and high excretion of ethylmalonic acid in urine.
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