目录号 | 产品详情 | 靶点 | |
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TN1624 | Calcium Channel ROS NO Synthase | ||
Ethyl cinnamate 是食品香料和化妆品添加剂,也是哺乳动物组织的优良清除剂。 | |||
TJS0315 | Apoptosis Lipoxygenase | ||
4-Methyldaphnetin (DHMC) 是一种合成 4-甲基香豆素衍生物的前体。它对几种肿瘤细胞株具有选择性的抗增殖和诱导凋亡的作用。它能够清除自由基,显著抑制膜脂过氧化。 | |||
TN1725 | Beta Amyloid ROS | ||
Hederacolchiside E 具有抗氧化活性,并通过调节氧化应激在阿尔茨海默病 (AD) 模型中显示神经保护作用。 Hederacolchiside E 对亚油酸乳液的脂质过氧化具有抑制作用。 Hederacolchiside E 可能通过阻断缓激肽或其他炎症介质发挥其抗炎作用。 | |||
T63992 | |||
KS100 是 ALDH 的有效抑制剂,能够作用于 ALDH1A1 (IC50: 334 nM)、ALDH2 (IC50: 2137 nM) 和 ALDH3A1 (IC50: 360 nM)。KS100 能够明显提高 ROS 活性、脂质过氧化和有毒醛的积累,且具有低毒性的抗增殖和抗癌活性。KS100 能够将细胞周期阻滞在 G2/M 期,并诱导细胞凋亡 (apoptosis)。 | |||
T63081 | |||
KS106 是一种 ALDH 的有效抑制剂,能够作用于 ALDH1A1 (IC50: 334 nM)、ALDH2 (IC50: 2137 nM) 和 ALDH3A1 (IC50: 360 nM)。KS106 具有抗增殖和抗癌作用,且毒性较低。KS106 可将细胞周期阻滞在G2/M 期,饼诱导细胞凋亡。KS106 能够明显提高 ROS 活性、脂质过氧化和有毒醛的积累。 | |||
T41242 | Reactive Oxygen Species | ||
Uric acid sodium 是氧自由基 (oxygen radical) 的清除剂,是一种有效的、常见的抗氧化剂,有助于维持机体血压稳定和抗氧化应激。Uric acid sodium 能清除活性氧 (ROS),如单线态氧和过氧亚硝酸盐,对脂质过氧化有抑制作用,与痛风性关节病的发病机理和草酸钙结石的形成有关。 | |||
T4313 | COX Glutathione Peroxidase | ||
Tinoridine hydrochloride (Y-3642 hydrochloride) 是非甾体抗炎药,具有显著的自由基清除和抗过氧化物特性。 | |||
T5S1097 | Apoptosis NF-κB Autophagy | ||
Neferine ((-)-Neferine) 是一种双苄基异喹啉类生物碱,可强效抑制NF-κB 激活,具有抗肿瘤活性。 | |||
T2924 | SGLT transporter Endogenous Metabolite | ||
Phloretin (NSC-407292) 是从苹果树叶中提取的一种查耳酮,具有抗炎、抗氧化和抗癌活性。它是真核尿素转运蛋白抑制剂,可阻断 VacA 介导的尿素和离子转运,有潜力用于类风湿性关节炎和过敏性气道炎症的相关研究。 | |||
T25829 | PDE | ||
Mopidamol (RA 233) 是一种磷酸二酯酶抑制剂,是 dipyridamole 衍生物,具有抗癌活性,可预防实验性糖尿病的视网膜血管缺陷。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPY-01588 | ALDH7A1 Protein, Human, Recombinant (His) | Human | E. coli | ||
ALDH7A1 (Aldehyde dehydrogenase 7 family, member A1) is a member of subfamily 7 in the aldehyde dehydrogenase family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Mammalian ALDH7A1 is homologous to plant ALDH7B1 which protects against various forms of stress such as increased salinity, dehydration and treatment with oxidants or pesticides. In mammals, ALDH7A1 is known to play a primary role during lysine catabolism through the NAD+-dependent oxidative conversion of aminoadipate semialdehyde (AASA) to its corresponding carboxylic acid, α-aminoadipic acid. Deleterious mutations in human ALDH7A1 are responsible for pyridoxine-dependent and folinic acid-responsive seizures. ALDH7A1 is a novel aldehyde dehydrogenase expressed in multiple subcellular compartments that protects against hyperosmotic stress by generating osmolytes and metabolizing toxic aldehydes.
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TMPY-02582 | Ferritin light chain Protein, Human, Recombinant (His) | Human | E. coli | ||
Ferritin, light polypeptide (FTL) is the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Storage of iron in the tissues occurs in the form of ferritin and hemosiderin. The latter originates from ferritin that has undergone intracellular digestion of its protein shell, leaving the iron core. Ferritin and hemosiderin are components of a continuum. Ferritin has been identified in all types of living organisms: animals, plants, molds, and bacteria. Whithin the protein shell of ferritin, iron is first oxidized to the ferric state for storage as ferric oxyhdroxide. Thus, ferritin removes excess iron from the cell sap where it could otherwise participate in peroxidation mechanisms.
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TMPY-02299 | ALDH3A1 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells | ||
Aldehyde dehydrogenase 3A1 (ALDH3A1) is a metabolic enzyme that catalyzes the oxidation of various aldehydes. Certain types of epithelial tissues in mammals, especially those continually exposed to environmental stress (e.g., corneal epithelium), express ALDH3A1 at high levels and its abundance in such tissues is perceived to help to maintain cellular homeostasis under conditions of oxidative stress. Metabolic as well as non-metabolic roles for ALDH3A1 have been associated with its mediated resistance to cellular oxidative stress. Aldehyde dehydrogenase 1A1 (ALDH1A1) and ALDH3A1 are corneal crystallins. They protect inner ocular tissues from ultraviolet radiation (UVR)-induced oxidative damage through catalytic and non-catalytic mechanisms. Additionally, ALDH3A1 has been postulated to play a regulatory role in the corneal epithelium based on several studies that report an inverse association between ALDH3A1 expression and corneal cell proliferation. Aldehyde dehydrogenase 3A1 (ALDH3A1) plays an important role in many cellular oxidative processes, including cancer chemoresistance, by metabolizing activated forms of oxazaphosphorine drugs such as cyclophosphamide (CP) and its analogues, such as mafosfamide (MF), ifosfamide (IFM), and 4-hydroperoxycyclophosphamide (4-HPCP). Compounds that can selectively target ALDH3A1 could permit delineation of its roles in these processes and could restore chemosensitivity in cancer cells that express this isoenzyme. ALDH3A1 may act to protect corneal cells against cellular oxidative damage by metabolizing toxic lipid peroxidation products (e.g., 4-HNE), maintaining cellular GSH levels and redox balance, and operating as an antioxidant.
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