目录号 | 产品详情 | 靶点 | |
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T19967 | Immunology/Inflammation related | ||
Fendosal (HP-129) 是一种非甾体抗炎药。在预防性和治疗性辅助诱导的慢性炎症多关节炎模型中,它的活性是阿司匹林的 6.9 至 9.5 倍。 | |||
T4561 | Others COX | ||
Tiaprofenic acid (Acido tiaprofenico) 是可口服的非甾体抗炎药,通过抑制环氧化酶抑制前列腺素合成,可用于风湿性疾病的研究。 | |||
T1421 | COX | ||
Aceclofenac (Preservex) 是一种可口服的非甾体抗炎药,可用于缓解疼痛、骨关节炎、强直性脊柱炎、类风湿性关节炎的研究。 | |||
T17036 | COX | ||
Tenidap is a non-steroidal anti-inflammatory drug and is a selective COX-1 inhibitor (IC50: 0.03 µM and 1.2 µM for COX-1 and COX-2, respectively). Tenidap is also a specific SLC26A3 inhibitor. | |||
T0055 | COX | ||
Glafenine (Glafenin) 是一种可用于缓解疼痛研究的非甾体抗炎药。 | |||
T30161 | P450 | ||
EN3356 是一种可口服且具有选择性的类固醇 17-α- 羟化酶/C17,20 裂解酶(CYP17A1 或 CYP17)抑制剂,是一种非甾体类裂解酶选择性化合物,具有潜在的抗雄激素和抗肿瘤活性。 | |||
T0448 | BCL Thrombin Cysteine Protease COX PPAR | ||
(S)-(+)-Ibuprofen (Dexibuprofen) 是 Ibuprofen 的 S(+)-对映异构体,能够有效的抑制COX-1(IC50:2.1 μM)和COX-2(IC50:1.6 μM),。它具有抗癌、退热、止痛,抗炎的效果。 | |||
T0484 | Apoptosis COX | ||
Deracoxib (SC 46) 是非甾体、非麻醉性抗炎药。 它也是选择性 cyclooxygenase-2 抑制剂,IC50 值:70 至 150 μM,抑制 3 种骨肉瘤细胞系。 | |||
T12361 | Others | ||
Parcetasal (MR-897) 是一种非甾类体抗炎剂,在缓解疼痛方面具有研究价值。 | |||
T0285 | COX | ||
Isoxicam (Isoxicamum) 是可口服的非甾体抗炎剂,可通过抑制环氧合酶 1 和 2 来阻断前列腺素的合成,可用于关节炎的研究。 |
目录号 | 产品名/同用名 | 种属 | 表达系统 | ||
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TMPH-01640 | MRGPRX2 Protein, Human, Recombinant (His) | Human | in vitro E. coli expression system | ||
Mast cell-specific receptor for basic secretagogues, i.e. cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core. Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction. Acts as a receptor for a number of other ligands, including peptides and alkaloids, such as cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A.
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